Fontem paginae Alfentanilum inspicere

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{| class="wikitable floatright"
|+ '''Alfentanilum'''
|-
| style="text-align: center" colspan="2" | [[Fasciculus:Alfentanil-2D-skeletal.svg|200px|Alfentanilum]]
|-
! colspan="2" | Natura chemica
|-
| style="font-size: 85%" | [[Formula chemica]] || style="font-size: 85%" | C<sub>21</sub>H<sub>32</sub>N<sub>6</sub>O<sub>3</sub>
|-
| style="font-size: 85%" | [[Massa molaris]] || style="font-size: 85%" | 416.517 g/mol
|-
| style="font-size: 85%" | [[PubChem]] || style="font-size: 85%" | [https://pubchem.ncbi.nlm.nih.gov/compound/51263 51263]
|-
| style="font-size: 85%" | [[DrugBank]] || style="font-size: 85%" | [https://www.drugbank.ca/drugs/DB00802 DB00802]
|-
! colspan="2" | Natura pharmacologica
|-
| style="font-size: 85%" | Codex ATC || style="font-size: 85%" | {{ATC|N01AH|02}}
|-
| style="font-size: 85%" | [[Tempus semivitae biologicum]] || style="font-size: 85%" | 90-111 min
|-
| style="font-size: 85%" | [[Metabolismus]] || style="font-size: 85%" | [[iecur|iecore]] (hepaticus):<br />[[CYP3A4]]<ref>{{cite journal |authors=Labroo RB, Thummel KE, Kunze KL, Podoll T, Trager WF, Kharasch ED |title=Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism |journal=Drug Metab Dispos |year=1995 |volume=23 |issue=4 |pages=490-6 |url=https://www.ncbi.nlm.nih.gov/pubmed/7600917}}</ref>
|-
| style="font-size: 85%" | [[Metabolitus|Metaboliti]] || style="font-size: 85%" | Noralfentanilum (NA)<br />N-phenylpropionamidum<br />(AMX)
|-
! colspan="2" | Ad usum therapeuticum
|-
| style="font-size: 85%" | Applicatio || style="font-size: 85%" | i.v.
|-
| style="font-size: 85%" | MedlinePlus || style="font-size: 85%" | [https://medlineplus.gov/druginfo/meds/a601130.html a601130]{{Nexus deficitur|date=October 2022 |bot=InternetArchiveBot |fix-attempted=yes }} {{Ling|Anglice}}
|}

'''Alfentanilum''' est [[medicamentum]], [[opioidum analgeticum| analgeticum opioidorum]], cuius effectus sedativi haud diuturni (15 min) cum initio rapido effectuum<ref>{{cite journal |authors=Miner JR, Gray R, Delavari P, Patel S, Patel R, Plummer D |title=Alfentanil for procedural sedation in the emergency department |journal=Ann Emerg Med |year=2011 |volume=57 |issue=2 |pages=117-21 |url=https://www.ncbi.nlm.nih.gov/pubmed/20947206}}.</ref> sunt. Opioidum ipsum effectus analgeticos suos per stimulationem [[receptorium opioidorum|receptoria opioidorum]] perficit. Hos ob effectus Alfentanilum in [[chirurgia]] imprimis substantia anaesthetica adhibetur. Alfentanilum rigorem thoraxis intermittentem efficere potest.

== Natura Alfentanili ==
=== Natura chemica ===
Nomen chemicum Alfentanili est N-[1-[2-(4-ethyl-5-oxo-1,4-dihydrotetrazol-1-yl)ethyl]-4-(methoxymethyl)-4-piperidyl]-N-phenyl-propanamidum, formula summarum sua est C<sub>21</sub>H<sub>32</sub>N<sub>6</sub>O<sub>3</sub>. [[Massa molaris]] est 416.517 g/mol. Valor [[pKa]] circiter 6.5 est itaque substantia apud pH physiologicum haud electrice oneratum videtur. 

=== Vicinitates chemicae ===
Alfentanili structura chemica [[Fentanylum|Fentanylo]] et [[Remifentanilum|Remifentanilo]] similis est.

== Effectus Alfentanili ==
=== Effectus adversi ===
Inter alios Alfentanilum rigorem thoraxis intermittentem efficere potest.

== Usus Alfentanili ==
=== Usus medicus ===
In [[anaesthesiologia]] doses 15–30 µg/kg applicantur, quod est cum pondus 62.0<ref>{{cite journal |authors=Walpole SC, Prieto-Merino D, Edwards P, Cleland J, Stevens G, Roberts I |title=The weight of nations: an estimation of adult human biomass |journal=BMC Public Health |year=2012 volume=12 |pages=439 |url=https://www.ncbi.nlm.nih.gov/pubmed/22709383}}</ref> [[Chiliogramma|kg]] / 136.7 lb circiter 1-2 mg applicari solere possint.

{{NexInt}}
* [[Anaesthesiologia]]
* [[Dolor]]

== Notae ==
<references />

[[Categoria:Analgetica]]