Izvorni kod stranice Ciprofloksacin

{{drugbox-lat 
| Watchedfields = 
| verifiedrevid = 443526033
| IUPAC_name = 1-ciklopropil-6-fluoro-4-okso-7-(piperazin-1-il)-hinolin-3-karboksilna kiselina
| image = Ciprofloxacin.svg
| width = 200
| image2 = Ciprofloxacin-zwitterion-from-xtal-3D-balls.png

<!--Clinical data-->
| tradename = Ciloxan, Cipro, Neofloxin
| Drugs.com = {{drugs.com-lat|monograph|ciprofloxacin-hydrochloride}}
| MedlinePlus = a688016
| licence_US = Ciprofloxacin
| pregnancy_AU = B3
| pregnancy_US = C
| legal_AU = S4
| legal_UK = POM
| legal_US = Rx-only
| routes_of_administration = [[Usta|Oralno]], [[intravenozna terapija|intravenozno]], topikalno

<!--Pharmacokinetic data-->
| bioavailability = 69%<ref>{{cite journal |author=Drusano GL, Standiford HC, Plaisance K, Forrest A, Leslie J, Caldwell J |title=Absolute oral bioavailability of ciprofloxacin |journal=Antimicrob Agents Chemother. |volume=30 |issue=3 |pages=444–6 |year=1986 |month=September |pmid=3777908 |pmc=180577 |url=http://aac.asm.org/cgi/pmidlookup?view=long&pmid=3777908 |doi= |issn=0066-4804}}</ref>
| metabolism = Hepatički, uključujući [[CYP1A2]]
| elimination_half-life = 4 sata
| excretion = Renal

<!--Identifiers-->
| CASNo_Ref = {{cascite|correct|CAS}}
| CAS_number_Ref = {{cascite|correct|}}
| CAS_number = 85721-33-1
| ATC_prefix = J01
| ATC_suffix = MA02
| ATC_supplemental = {{ATC|S01|AE03}} {{ATC|S02|AA15}} {{ATC|S03|AA07}}
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 100241
| PubChem = 2764
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00537
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2662
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 5E8K9I0O4U
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00186
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 8
| NIAID_ChemDB = 001992

<!--Chemical data-->
| C=17 | H=18 | F=1 | N=3 | O=3 
| molecular_weight = 331,346
| smiles = c1c2c(cc(c1F)N3CCNCC3)n(cc(c2=O)C(=O)O)C4CC4
| InChI = 1/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = MYSWGUAQZAJSOK-UHFFFAOYSA-N
}}
'''Ciprofloksacin''' ([[International Nonproprietary Name|INN]]) pripada drugoj generaciji [[fluorohinolon]]skih [[antibiotik]]a.<ref>{{Cite journal | last1 = Nelson | first1 = JM. | last2 = Chiller | first2 = TM. | last3 = Powers | first3 = JH. | last4 = Angulo | first4 = FJ. | title = Fluoroquinolone-resistant Campylobacter species and the withdrawal of fluoroquinolones from use in poultry: a public health success story. | journal = Clin Infect Dis | volume = 44 | issue = 7 | pages = 977–80 | month = Apr | year = 2007 | doi = 10.1086/512369 | pmid = 17342653 }}</ref><ref>{{Cite journal | last1 = Kawahara | first1 = S. | title = [Chemotherapeutic agents under study] | journal = Nippon Rinsho | volume = 56 | issue = 12 | pages = 3096–9 | month = Dec | year = 1998 | pmid = 9883617 }}</ref> Njegov spektar delovanja obuhvata većinu sojeva bakterijskih patogena odgovornih za respiratorne, urinarne, gastrointestinalne, i abdomenalne infekcije, uključujući [[Gram negativne bakterije|Gram-negativne]] (''[[Escherichia coli]]'', ''[[Haemophilus influenzae]]'', ''[[Klebsiella pneumoniae]]'', ''[[Legionella pneumophila]]'', ''[[Moraxella catarrhalis]]'', ''[[Proteus mirabilis]]'', i ''[[Pseudomonas aeruginosa]]''), i [[Gram pozitivne bakterije|Gram-positivne]] (meticilin-senzitivni ali ne meticilin-rezistentni ''[[Staphylococcus aureus]]'', ''[[Streptococcus pneumoniae]]'', ''[[Staphylococcus epidermidis]]'', ''[[Enterococcus faecalis]]'', i ''[[Streptococcus pyogenes]]'') bakterijske patogene. Ciprofloksacin i drugi fluorohinoloni su vredni zbog njihovog širokog spektra aktivnosti, odlične penetracije tkiva, kao i njihove dostupnosti u oralnim i intravenskim formulacijama.<ref name="BruntonLazo2005">{{cite book|last1=Brunton|first1=Laurence|last2=Lazo|first2=John|last3=Parker|first3=Keith|title=Goodman & Gilman's The Pharmacological Basis of Therapeutics|url=http://books.google.com/books?id=PtWdBgnQdjMC|accessdate = 30. 10. 2012.|year=2005|publisher=McGraw-Hill Prof Med/Tech|isbn=978-0-07-142280-2}}</ref>

== Reference ==
{{reflist|}}

== Spoljašnje veze ==
{{Portal-lat|Medicina|Hemija}}
{{Commonscat-lat|Ciprofloxacin|Ciprofloksacin}}
* {{Dmoz|Society/Issues/Health/Drugs/Medical}}
* [http://health.howstuffworks.com/cipro.htm How Stuff Works - Cipro]
* [http://druginfo.nlm.nih.gov/drugportal/dpdirect.jsp?name=Ciprofloxacin U.S. National Library of Medicine: Drug Information Portal - Ciprofloxacin]
* [http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019537s075,020780s033lbl.pdf Cipro Package Insert]
* [http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021744s008lbl.pdf Proquin XR Package Insert]
* [http://www.accessdata.fda.gov/drugsatfda_docs/label/2006/019992s020lbl.pdf Ciloxan Package Insert]
* [http://www.nlm.nih.gov/medlineplus/druginfo/meds/a605005.html Ciprofloxacin Ophthalmic]

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{{Antibiotici inhibitori nukleinskih kiselina-lat}}

[[Kategorija:Ciklopropani]]
[[Kategorija:Fluorohinolonski antibiotici]]
[[Kategorija:Otologici]]
[[Kategorija:Oftalmološki lekovi]]
[[Kategorija:Piperazini]]