Izvorni kod stranice Hijaluronan

{{Chembox-lat
| verifiedrevid = 443055112
|  ImageFile1 = Hyaluronan.png
|  ImageSize1 = 300px
| Section1 = {{Chembox Identifiers-lat
|  ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2341172
| SMILES = [Na+].O=C(N[C@H]4[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]4O[C@@H]3O[C@H](C(=O)O)[C@@H](O[C@@H]2O[C@@H]([C@@H](O)[C@H](O[C@@H]1O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]1O)[C@H]2NC(=O)C)CO)[C@H](O)[C@H]3O)C
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = S270N0TRQY
| InChIKey = YWIVKILSMZOHHF-QJZPQSOGBN
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1
|  StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
|  Beilstein = 
|  Gmelin = 
|  3DMet = 
| StdInChIKey = YWIVKILSMZOHHF-QJZPQSOGSA-N
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = 9004-61-9
| CASNo1 = 31799-91-4
| CASNo1_Comment = (so kalijuma)
| CASNo2 = 9067-32-7
| CASNo2_Comment = (so natrijuma)
| InChI = 1/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1
| ATCCode_prefix = D03
| ATCCode_suffix = AX05
| ATC_Supplemental = {{ATC|M09|AX01}}, {{ATC|R01|AX09}}, {{ATC|S01|KA01}}
}}
| Section2 = {{Chembox Properties-lat
|  Formula = (C<sub>14</sub>H<sub>21</sub>NO<sub>11</sub>)<sub>n</sub>
| Solubility = rastvoran (so natrijuma)
  }}
| Section7 = {{Chembox Hazards-lat
|  SPhrases = {{S22}}, {{S24/25}} (so natrijuma)
|  LD50 = > 2400 mg/kg (miš, oralno, so natrijuma)<br /> >4000 mg/kg (miš, supkutano, so natrijuma)<br />1500 mg/kg (miš, intraperitonalno, so natrijuma)
  }}
| Section8 = {{Chembox Related-lat
|   OtherCpds = [[Glukuronska kiselina|D-glukuronska kiselina]] i [[N-Acetilglukozamin|D-N-acetilglukozamin]] (monomeri)
  }}
}}

'''Hijaluronan''' (''hijaluronska kiselina'', ''hijaluronat'', HA) je [[anjon]]ski, [[Sulfatacija|nesulfatisani]] [[glikozaminoglikan]] koji je prisutan širom [[vezivno tkivo|vezivnog]], [[epitel]]nog, i [[neuron]]skog tkiva. On je jedinstven među glikozaminoglikanima po tome što nonsulfatisan, da se formira u [[ćelijska membrana|ćelijskoj membrani]] umesto [[Goldžijev aparat|Goldžijevog aparata]], i što može da bude veoma velik, sa [[molekulska težina|molekulskom težinom]] koja često doseže milione daltona.<ref>{{cite journal
 | last=Frasher
 | first=J.R.E ''et al'
 | title=Hyaluronan: its nature, distribution, functions and turnover
 | journal=Journal of Internal Medicine
 | year=1997
 | volume=242
 | pages=27&ndash;33
 | format=PDF
 | accessdate=2009-06-05
 | doi=10.1046/j.1365-2796.1997.00170.x
 | url=http://www3.interscience.wiley.com.iiiprxy.library.miami.edu/cgi-bin/fulltext/119157843/PDFSTART
 | last2=Laurent
 | first2=T. C.
 | last3=Laurent
 | first3=U. B. G.
 | pmid=9260563
 | issue=1
 | archive-date=2012-12-14
 | archive-url=https://archive.today/20121214192516/http://www3.interscience.wiley.com.iiiprxy.library.miami.edu/cgi-bin/fulltext/119157843/PDFSTART
 | dead-url=yes
 }}</ref>
Kao jedna od glavnih komponenti [[ekstracelularni matriks|ekstracelularnog matriksa]], hijaluronan u znatnoj meri doprinosi ćelijskoj proliferaciji i migraciji, a može takođe da uzme udela i u progresiji pojednih malignih [[tumor]]a.

U proseku osoba sa 70&nbsp;kg (154&nbsp;lbs) ima oko 15&nbsp;grama hijaluronan u telu, jedna trećina od čega se pretvara (razgrađuje i sintetiše) svakog dana.<ref>{{cite journal|author=Stern R | title=Hyaluronan catabolism: a new metabolic pathway | journal=Eur J Cell Biol|volume=83 | issue=7 | pages=317–25 | month=August | year=2004 | pmid = 15503855 | accessdate= | doi=10.1078/0171-9335-00392}}</ref> Hijaluronska kiselina je isto tako komponenta [[Streptococcus|grupe A streptococcal]] ekstracelularnih [[kapsula (mikrobiologija)|kapsula]],<ref>{{Cite journal
 | last =Sugahara
 | first =K.
 | coauthors =N.B. Schwartz and A. Dorfman
 | year =1979
 | title =Biosynthesis of hyaluronic acid by ''Streptococcus''
 | journal =Journal of Biological Chemistry
 | volume =254
 | issue =14
 | pages =6252–6261
 | url =http://www.jbc.org/content/254/14/6252.full.pdf
 | pmid =376529
}}</ref> i smatra se da učestvuje u [[Patogenost i virulencija|virulenciji]].<ref>{{Cite journal
 | last =Wessels
 | first =M.R.
 | coauthors =A.E. Moses, J.B. Goldberg and T.J. DiCesare
 | year =1991
 | title =Hyaluronic acid capsule is a virulence factor for mucoid group A streptococci
 | journal =PNAS
 | publisher =
 | volume =88
 | issue =19
 | pages =8317–8321
 | url =http://www.pnas.org/content/88/19/8317.full.pdf
 | pmid =1656437
 | doi =10.1073/pnas.88.19.8317
 | pmc =52499
}}</ref><ref>{{Cite journal
 | last =Schrager
 | first =H.M.
 | coauthors =J.G. Rheinwald and M.R. Wessels
 | year =1996
 | title =Hyaluronic acid capsule and the role of streptococcal entry into keratinocytes in invasive skin infection
 | journal =Journal of Clinical Investigation
 | volume =98
 | issue =9
 | pages =1954–1958
 | url =http://www.jci.org/articles/view/118998/pdf
 | pmid =8903312
 | doi =10.1172/JCI118998
 | pmc =507637
}}</ref>

== Reference ==
{{Reflist|2}}

== Povezano ==
* [[Alguronska kiselina]]

== Spoljašnje veze ==
* [[ATC klasifikacija|ATC kodovi]]: {{ATC|D03|AX05}}, {{ATC|M09|AX01}}, {{ATC|R01|AX09}}, {{ATC|S01|KA01}}
* {{MeshName|Hyaluronan}}
* [http://ehyaluronicacid.com/ Hyaluronic acid benefits] {{Webarchive|url=https://web.archive.org/web/20121113190551/http://ehyaluronicacid.com/ |date=2012-11-13 }}
{{Ugljeni hidrati-lat}}

[[Kategorija:Glikozaminoglikani]]