Burantashi - Revision history

Ttocserp: Merged into Corynanthe johimbe as per talk page, nobody opposing.

2022-12-12T10:44:00Z

Merged into Corynanthe johimbe as per talk page, nobody opposing.

← Previous revision		Revision as of 10:44, 12 December 2022
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			#REDIRECT [[Corynanthe johimbe]]
	{{merge to\|Corynanthe johimbe\|discuss=Talk:Corynanthe johimbe#Merger proposal\|date=December 2022}}
	{{multiple issues\|
	{{more medical citations needed\|date=February 2014}}
	{{more citations needed\|date=March 2009}}
	{{technical\|date=July 2019}}
	{{Orphan\|date=March 2022}}
	}}

	'''Burantashi''' (literally "penis get up") is a native [[Hausa people\|Hausa]]-[[Fulani]] powder derived from the bark of the African tree ''[[Pausinystalia johimbe]]''.

	Burantashi is used as a food additive to barbecued meat (suya) in [[Nigeria]], especially the Northern parts. The extracts contain the [[alkaloid]] [[yohimbine]], an [[Alpha-2 adrenergic receptor\|alpha-<sub>2</sub>]] [[receptor antagonist\|antagonist]] that has been studied for treating [[erectile dysfunction]], but the whole bark of the tree was not studied until recently. In one recent study, pure Burantashi powder obtained from a local suya vendor in [[Lagos, Nigeria]] was extracted aqueously and studied on the renal circulation of [[Sprague-Dawley rat]]s.<ref name=Ajayi>Ajayi AA, Newaz M, Hercule H, Saleh M, Bode CO, Oyekan AO. Endothelin -like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague-Dawley rats. ''Methods. Find. Expt. Clin. Pharmacol''. 2003, 25(10): 817-22.</ref> In the ''in vivo'' study, the extract code-named "CCD-X", caused a rise in [[mean arterial pressure]] (MAP), and a rise in [[renal medulla]]ry blood flow (MBF). This systemic [[vasoconstrictor]] and renal medullary dilator action was attenuated separately by the endothelin -A receptor blocker - BMS-182874, ET-B blocker -BQ788, but blocked by their combination.<ref name=Ajayi/> Further, the [[nitric oxide]] inhibitor (NO), L-Nomega - nitro-Arginine Methyl Ester (L-NAME) 10 mg/kg totally inhibited the rise in medullary blood flow due to CCD-X. ''In vitro'' studies in isolated perfused kidneys (IPK) and in pressurised microvessels (PMV) confirmed the ''in vivo'' effect to cause [[vasoconstriction]], which was inhibited by [[endothelin]] A and B antagonists. The pressor dose response characteristic of CCD-X on PMV was similar to that of endothelin-1 with EC<sub>50</sub> close to 100 ng. It was concluded from these studies that, the aqueous extract exhibited a vasoconstrictor effect -possibly alpha-<sub>2</sub> mediated like yohimbine. However, it possessed additional effects as an andothelin receptor A and B agonist, and also released nitric oxide. The possibility of a post-receptor cross-talk among ET-B, alpha-2 receptors and NO release was also considered. [[Thin layer chromatography]] showed that the bark is rich in [[sesquiterpene]]s, and has [[antifungal medication\|antifungal]] and [[antibiotic]] properties as well. Whether CCD-X will be useful in [[sickle cell disease]] (releasing NO) is unknown. Further basic and clinical research are needed before the effects of Burantashi can be effectively evaluated.

	==References==
	{{reflist}}

	==External links==
	* [https://web.archive.org/web/20060822150629/http://www.sunnewsonline.com/webpages/features/travels/2004/dec/30/travels-30-12-2004-001.htm Article in the Daily Sun newspaper of Nigeria]

	[[Category:Traditional African medicine]]
	[[Category:Erectile dysfunction drugs]]
	[[Category:Natural products]]

Lalaithan: added merge proposal template

2022-12-04T09:06:56Z

added merge proposal template

← Previous revision		Revision as of 09:06, 4 December 2022
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			{{merge to\|Corynanthe johimbe\|discuss=Talk:Corynanthe johimbe#Merger proposal\|date=December 2022}}
	{{multiple issues\|		{{multiple issues\|
	{{more medical citations needed\|date=February 2014}}		{{more medical citations needed\|date=February 2014}}

Lalaithan: added categories

2022-11-30T18:47:12Z

added categories

← Previous revision		Revision as of 18:47, 30 November 2022
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	[[Category:Traditional African medicine]]		[[Category:Traditional African medicine]]
			[[Category:Erectile dysfunction drugs]]
			[[Category:Natural products]]

Lalaithan: /* See also */ removed section as the only link is unrelated

2022-11-30T18:16:21Z

See also: removed section as the only link is unrelated

← Previous revision		Revision as of 18:16, 30 November 2022
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	Burantashi is used as a food additive to barbecued meat (suya) in [[Nigeria]], especially the Northern parts. The extracts contain the [[alkaloid]] [[yohimbine]], an [[Alpha-2 adrenergic receptor\|alpha-<sub>2</sub>]] [[receptor antagonist\|antagonist]] that has been studied for treating [[erectile dysfunction]], but the whole bark of the tree was not studied until recently. In one recent study, pure Burantashi powder obtained from a local suya vendor in [[Lagos, Nigeria]] was extracted aqueously and studied on the renal circulation of [[Sprague-Dawley rat]]s.<ref name=Ajayi>Ajayi AA, Newaz M, Hercule H, Saleh M, Bode CO, Oyekan AO. Endothelin -like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague-Dawley rats. ''Methods. Find. Expt. Clin. Pharmacol''. 2003, 25(10): 817-22.</ref> In the ''in vivo'' study, the extract code-named "CCD-X", caused a rise in [[mean arterial pressure]] (MAP), and a rise in [[renal medulla]]ry blood flow (MBF). This systemic [[vasoconstrictor]] and renal medullary dilator action was attenuated separately by the endothelin -A receptor blocker - BMS-182874, ET-B blocker -BQ788, but blocked by their combination.<ref name=Ajayi/> Further, the [[nitric oxide]] inhibitor (NO), L-Nomega - nitro-Arginine Methyl Ester (L-NAME) 10 mg/kg totally inhibited the rise in medullary blood flow due to CCD-X. ''In vitro'' studies in isolated perfused kidneys (IPK) and in pressurised microvessels (PMV) confirmed the ''in vivo'' effect to cause [[vasoconstriction]], which was inhibited by [[endothelin]] A and B antagonists. The pressor dose response characteristic of CCD-X on PMV was similar to that of endothelin-1 with EC<sub>50</sub> close to 100 ng. It was concluded from these studies that, the aqueous extract exhibited a vasoconstrictor effect -possibly alpha-<sub>2</sub> mediated like yohimbine. However, it possessed additional effects as an andothelin receptor A and B agonist, and also released nitric oxide. The possibility of a post-receptor cross-talk among ET-B, alpha-2 receptors and NO release was also considered. [[Thin layer chromatography]] showed that the bark is rich in [[sesquiterpene]]s, and has [[antifungal medication\|antifungal]] and [[antibiotic]] properties as well. Whether CCD-X will be useful in [[sickle cell disease]] (releasing NO) is unknown. Further basic and clinical research are needed before the effects of Burantashi can be effectively evaluated.		Burantashi is used as a food additive to barbecued meat (suya) in [[Nigeria]], especially the Northern parts. The extracts contain the [[alkaloid]] [[yohimbine]], an [[Alpha-2 adrenergic receptor\|alpha-<sub>2</sub>]] [[receptor antagonist\|antagonist]] that has been studied for treating [[erectile dysfunction]], but the whole bark of the tree was not studied until recently. In one recent study, pure Burantashi powder obtained from a local suya vendor in [[Lagos, Nigeria]] was extracted aqueously and studied on the renal circulation of [[Sprague-Dawley rat]]s.<ref name=Ajayi>Ajayi AA, Newaz M, Hercule H, Saleh M, Bode CO, Oyekan AO. Endothelin -like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague-Dawley rats. ''Methods. Find. Expt. Clin. Pharmacol''. 2003, 25(10): 817-22.</ref> In the ''in vivo'' study, the extract code-named "CCD-X", caused a rise in [[mean arterial pressure]] (MAP), and a rise in [[renal medulla]]ry blood flow (MBF). This systemic [[vasoconstrictor]] and renal medullary dilator action was attenuated separately by the endothelin -A receptor blocker - BMS-182874, ET-B blocker -BQ788, but blocked by their combination.<ref name=Ajayi/> Further, the [[nitric oxide]] inhibitor (NO), L-Nomega - nitro-Arginine Methyl Ester (L-NAME) 10 mg/kg totally inhibited the rise in medullary blood flow due to CCD-X. ''In vitro'' studies in isolated perfused kidneys (IPK) and in pressurised microvessels (PMV) confirmed the ''in vivo'' effect to cause [[vasoconstriction]], which was inhibited by [[endothelin]] A and B antagonists. The pressor dose response characteristic of CCD-X on PMV was similar to that of endothelin-1 with EC<sub>50</sub> close to 100 ng. It was concluded from these studies that, the aqueous extract exhibited a vasoconstrictor effect -possibly alpha-<sub>2</sub> mediated like yohimbine. However, it possessed additional effects as an andothelin receptor A and B agonist, and also released nitric oxide. The possibility of a post-receptor cross-talk among ET-B, alpha-2 receptors and NO release was also considered. [[Thin layer chromatography]] showed that the bark is rich in [[sesquiterpene]]s, and has [[antifungal medication\|antifungal]] and [[antibiotic]] properties as well. Whether CCD-X will be useful in [[sickle cell disease]] (releasing NO) is unknown. Further basic and clinical research are needed before the effects of Burantashi can be effectively evaluated.

	==See also==
	* [[Sani Abacha]]

	==References==		==References==

Dewritech: /* top */clean up, added orphan tag

2022-03-15T08:32:08Z

top: clean up, added orphan tag

← Previous revision		Revision as of 08:32, 15 March 2022
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	{{multiple issues\|		{{multiple issues\|
	{{~~medref~~\|date=February 2014}}		{{more medical citations needed\|date=February 2014}}
	{{~~refimprove~~\|date=March 2009}}		{{more citations needed\|date=March 2009}}
	{{technical\|date=July 2019}}		{{technical\|date=July 2019}}
			{{Orphan\|date=March 2022}}
	}}		}}

	'''Burantashi''' (literally "penis get up") is a native [[Hausa people\|Hausa]]-[[Fulani]] powder derived from the bark of the African tree ''[[Pausinystalia johimbe]]''.		'''Burantashi''' (literally "penis get up") is a native [[Hausa people\|Hausa]]-[[Fulani]] powder derived from the bark of the African tree ''[[Pausinystalia johimbe]]''.

	Burantashi is used as a food additive to barbecued meat (suya) in [[Nigeria]], especially the Northern parts. The extracts contain the [[alkaloid]] [[yohimbine]], an [[Alpha-2 adrenergic receptor\|alpha-<sub>2</sub>]] [[receptor antagonist\|antagonist]] that has been studied for treating [[erectile dysfunction]], but the whole bark of the tree was not studied until recently. In one recent study, pure Burantashi powder obtained from a local suya vendor in [[Lagos, Nigeria]] was extracted aqueously and studied on the renal circulation of [[Sprague-Dawley rat]]s.<ref name=Ajayi>Ajayi AA, Newaz M, Hercule H, Saleh M, Bode CO, Oyekan AO. Endothelin -like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague-Dawley rats. ''Methods. Find. Expt. Clin. Pharmacol''. 2003, 25(10): 817-22.</ref> In the ''in vivo'' study, the extract code-named "CCD-X", caused a rise in [[mean arterial pressure]] (MAP), and a rise in [[renal medulla]]ry blood flow (MBF). This systemic [[vasoconstrictor]] and renal medullary dilator action was attenuated separately by the endothelin -A receptor blocker - BMS-182874, ET-B blocker -BQ788, but blocked by their combination.<ref name=Ajayi/> Further, the [[nitric oxide]] inhibitor (NO), L-Nomega - nitro-Arginine Methyl Ester (L-NAME) 10 mg/kg totally inhibited the rise in medullary blood flow due to CCD-X. ''In vitro'' studies in isolated perfused kidneys (IPK) and in pressurised microvessels (PMV) confirmed the ''in vivo'' effect to cause [[vasoconstriction]], which was inhibited by [[endothelin]] A and B antagonists. The pressor dose response characteristic of CCD-X on PMV was similar to that of endothelin-1 with EC<sub>50</sub> close to 100 ng. It was concluded from these studies that, the aqueous extract exhibited a vasoconstrictor effect -possibly alpha-<sub>2</sub> mediated like yohimbine. However, it possessed additional effects as an andothelin receptor A and B agonist, and also released nitric oxide. The possibility of a post-receptor cross-talk among ET-B, alpha-2 receptors and NO release was also considered. [[Thin layer chromatography]] showed that the bark is rich in [[sesquiterpene]]s, and has [[antifungal medication\|antifungal]] and [[antibiotic]] properties as well. Whether CCD-X will be useful in [[sickle cell disease]] (releasing NO) is unknown. Further basic and clinical research are needed before the effects of Burantashi can be effectively evaluated.		Burantashi is used as a food additive to barbecued meat (suya) in [[Nigeria]], especially the Northern parts. The extracts contain the [[alkaloid]] [[yohimbine]], an [[Alpha-2 adrenergic receptor\|alpha-<sub>2</sub>]] [[receptor antagonist\|antagonist]] that has been studied for treating [[erectile dysfunction]], but the whole bark of the tree was not studied until recently. In one recent study, pure Burantashi powder obtained from a local suya vendor in [[Lagos, Nigeria]] was extracted aqueously and studied on the renal circulation of [[Sprague-Dawley rat]]s.<ref name=Ajayi>Ajayi AA, Newaz M, Hercule H, Saleh M, Bode CO, Oyekan AO. Endothelin -like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague-Dawley rats. ''Methods. Find. Expt. Clin. Pharmacol''. 2003, 25(10): 817-22.</ref> In the ''in vivo'' study, the extract code-named "CCD-X", caused a rise in [[mean arterial pressure]] (MAP), and a rise in [[renal medulla]]ry blood flow (MBF). This systemic [[vasoconstrictor]] and renal medullary dilator action was attenuated separately by the endothelin -A receptor blocker - BMS-182874, ET-B blocker -BQ788, but blocked by their combination.<ref name=Ajayi/> Further, the [[nitric oxide]] inhibitor (NO), L-Nomega - nitro-Arginine Methyl Ester (L-NAME) 10 mg/kg totally inhibited the rise in medullary blood flow due to CCD-X. ''In vitro'' studies in isolated perfused kidneys (IPK) and in pressurised microvessels (PMV) confirmed the ''in vivo'' effect to cause [[vasoconstriction]], which was inhibited by [[endothelin]] A and B antagonists. The pressor dose response characteristic of CCD-X on PMV was similar to that of endothelin-1 with EC<sub>50</sub> close to 100 ng. It was concluded from these studies that, the aqueous extract exhibited a vasoconstrictor effect -possibly alpha-<sub>2</sub> mediated like yohimbine. However, it possessed additional effects as an andothelin receptor A and B agonist, and also released nitric oxide. The possibility of a post-receptor cross-talk among ET-B, alpha-2 receptors and NO release was also considered. [[Thin layer chromatography]] showed that the bark is rich in [[sesquiterpene]]s, and has [[antifungal medication\|antifungal]] and [[antibiotic]] properties as well. Whether CCD-X will be useful in [[sickle cell disease]] (releasing NO) is unknown. Further basic and clinical research are needed before the effects of Burantashi can be effectively evaluated.

AnomieBOT: Dating maintenance tags: {{Technical}}

2019-07-05T22:08:58Z

Dating maintenance tags: {{Technical}}

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	{{refimprove\|date=March 2009}}		{{refimprove\|date=March 2009}}
	{{technical}}		{{technical\|date=July 2019}}
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Deli nk at 21:48, 5 July 2019

2019-07-05T21:48:04Z

← Previous revision		Revision as of 21:48, 5 July 2019
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	{{medref\|date=February 2014}}		{{medref\|date=February 2014}}
	{{refimprove\|date=March 2009}}		{{refimprove\|date=March 2009}}
			{{technical}}
	}}		}}

	'''Burantashi''' (literally "penis get up") is a native [[Hausa people\|Hausa]]-[[Fulani]] powder derived from the bark of the African tree ''[[Pausinystalia johimbe]]''.		'''Burantashi''' (literally "penis get up") is a native [[Hausa people\|Hausa]]-[[Fulani]] powder derived from the bark of the African tree ''[[Pausinystalia johimbe]]''.

	Burantashi is used as a food additive to barbecued meat (suya) in [[Nigeria]], especially the Northern parts. The extracts contain the [[alkaloid]] [[yohimbine]], an [[Alpha-2 adrenergic receptor\|alpha-<sub>2</sub>]] [[receptor antagonist\|antagonist]] that has been ~~used~~ ~~widely~~ ~~with variable success in~~ [[erectile dysfunction]], but the whole bark of the tree was not studied until recently. In one recent study, pure Burantashi powder obtained from a local suya vendor in [[Lagos, Nigeria]] was extracted aqueously and studied on the renal circulation of [[Sprague-Dawley rat]]s.<ref name=Ajayi>Ajayi AA, Newaz M, Hercule H, Saleh M, Bode CO, Oyekan AO. Endothelin -like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague-Dawley rats. ''Methods. Find. Expt. Clin. Pharmacol''. 2003, 25(10): 817-22.</ref> In the ''in vivo'' study, the extract code-named "CCD-X", caused a rise in [[mean arterial pressure]] (MAP), and a rise in [[renal medulla]]ry blood flow (MBF). This systemic [[vasoconstrictor]] and renal medullary dilator action was attenuated separately by the endothelin -A receptor blocker - BMS-182874, ET-B blocker -BQ788, but blocked by their combination.<ref name=Ajayi/> Further, the [[nitric oxide]] inhibitor (NO), L-Nomega - nitro-Arginine Methyl Ester (L-NAME) 10 mg/kg totally inhibited the rise in medullary blood flow due to CCD-X. ''In vitro'' studies in isolated perfused kidneys (IPK) and in pressurised microvessels (PMV) confirmed the ''in vivo'' effect to cause [[vasoconstriction]], which was inhibited by [[endothelin]] A and B antagonists. The pressor dose response characteristic of CCD-X on PMV was similar to that of endothelin-1 with EC<sub>50</sub> close to 100 ng. It was concluded from these studies that, the aqueous extract exhibited a vasoconstrictor effect -possibly alpha-<sub>2</sub> mediated like yohimbine. However, it possessed additional effects as an andothelin receptor A and B agonist, and also released nitric oxide. The possibility of a post-receptor cross-talk among ET-B, alpha-2 receptors and NO release was also considered. [[Thin layer chromatography]] showed that the bark is rich in [[sesquiterpene]]s, and has [[antifungal medication\|antifungal]] and [[antibiotic]] properties as well. Whether CCD-X will be useful in [[sickle cell disease]] (releasing NO) is unknown. Further basic and clinical research are needed before the effects of Burantashi can be effectively evaluated.		Burantashi is used as a food additive to barbecued meat (suya) in [[Nigeria]], especially the Northern parts. The extracts contain the [[alkaloid]] [[yohimbine]], an [[Alpha-2 adrenergic receptor\|alpha-<sub>2</sub>]] [[receptor antagonist\|antagonist]] that has been studied for treating [[erectile dysfunction]], but the whole bark of the tree was not studied until recently. In one recent study, pure Burantashi powder obtained from a local suya vendor in [[Lagos, Nigeria]] was extracted aqueously and studied on the renal circulation of [[Sprague-Dawley rat]]s.<ref name=Ajayi>Ajayi AA, Newaz M, Hercule H, Saleh M, Bode CO, Oyekan AO. Endothelin -like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague-Dawley rats. ''Methods. Find. Expt. Clin. Pharmacol''. 2003, 25(10): 817-22.</ref> In the ''in vivo'' study, the extract code-named "CCD-X", caused a rise in [[mean arterial pressure]] (MAP), and a rise in [[renal medulla]]ry blood flow (MBF). This systemic [[vasoconstrictor]] and renal medullary dilator action was attenuated separately by the endothelin -A receptor blocker - BMS-182874, ET-B blocker -BQ788, but blocked by their combination.<ref name=Ajayi/> Further, the [[nitric oxide]] inhibitor (NO), L-Nomega - nitro-Arginine Methyl Ester (L-NAME) 10 mg/kg totally inhibited the rise in medullary blood flow due to CCD-X. ''In vitro'' studies in isolated perfused kidneys (IPK) and in pressurised microvessels (PMV) confirmed the ''in vivo'' effect to cause [[vasoconstriction]], which was inhibited by [[endothelin]] A and B antagonists. The pressor dose response characteristic of CCD-X on PMV was similar to that of endothelin-1 with EC<sub>50</sub> close to 100 ng. It was concluded from these studies that, the aqueous extract exhibited a vasoconstrictor effect -possibly alpha-<sub>2</sub> mediated like yohimbine. However, it possessed additional effects as an andothelin receptor A and B agonist, and also released nitric oxide. The possibility of a post-receptor cross-talk among ET-B, alpha-2 receptors and NO release was also considered. [[Thin layer chromatography]] showed that the bark is rich in [[sesquiterpene]]s, and has [[antifungal medication\|antifungal]] and [[antibiotic]] properties as well. Whether CCD-X will be useful in [[sickle cell disease]] (releasing NO) is unknown. Further basic and clinical research are needed before the effects of Burantashi can be effectively evaluated.

	==See also==		==See also==

Wbm1058: Spelling correction; redirect bypass from Pausinystalia yohimbe to Pausinystalia johimbe using popups

2019-01-16T15:20:41Z

Spelling correction; redirect bypass from Pausinystalia yohimbe to Pausinystalia johimbe using popups

← Previous revision		Revision as of 15:20, 16 January 2019
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	}}		}}

	'''Burantashi''' (literally "penis get up") is a native [[Hausa people\|Hausa]]-[[Fulani]] powder derived from the bark of the African tree ''[[Pausinystalia ~~yohimbe~~]]''.		'''Burantashi''' (literally "penis get up") is a native [[Hausa people\|Hausa]]-[[Fulani]] powder derived from the bark of the African tree ''[[Pausinystalia johimbe]]''.

	Burantashi is used as a food additive to barbecued meat (suya) in [[Nigeria]], especially the Northern parts. The extracts contain the [[alkaloid]] [[yohimbine]], an [[Alpha-2 adrenergic receptor\|alpha-<sub>2</sub>]] [[receptor antagonist\|antagonist]] that has been used widely with variable success in [[erectile dysfunction]], but the whole bark of the tree was not studied until recently. In one recent study, pure Burantashi powder obtained from a local suya vendor in [[Lagos, Nigeria]] was extracted aqueously and studied on the renal circulation of [[Sprague-Dawley rat]]s.<ref name=Ajayi>Ajayi AA, Newaz M, Hercule H, Saleh M, Bode CO, Oyekan AO. Endothelin -like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague-Dawley rats. ''Methods. Find. Expt. Clin. Pharmacol''. 2003, 25(10): 817-22.</ref> In the ''in vivo'' study, the extract code-named "CCD-X", caused a rise in [[mean arterial pressure]] (MAP), and a rise in [[renal medulla]]ry blood flow (MBF). This systemic [[vasoconstrictor]] and renal medullary dilator action was attenuated separately by the endothelin -A receptor blocker - BMS-182874, ET-B blocker -BQ788, but blocked by their combination.<ref name=Ajayi/> Further, the [[nitric oxide]] inhibitor (NO), L-Nomega - nitro-Arginine Methyl Ester (L-NAME) 10 mg/kg totally inhibited the rise in medullary blood flow due to CCD-X. ''In vitro'' studies in isolated perfused kidneys (IPK) and in pressurised microvessels (PMV) confirmed the ''in vivo'' effect to cause [[vasoconstriction]], which was inhibited by [[endothelin]] A and B antagonists. The pressor dose response characteristic of CCD-X on PMV was similar to that of endothelin-1 with EC<sub>50</sub> close to 100 ng. It was concluded from these studies that, the aqueous extract exhibited a vasoconstrictor effect -possibly alpha-<sub>2</sub> mediated like yohimbine. However, it possessed additional effects as an andothelin receptor A and B agonist, and also released nitric oxide. The possibility of a post-receptor cross-talk among ET-B, alpha-2 receptors and NO release was also considered. [[Thin layer chromatography]] showed that the bark is rich in [[sesquiterpene]]s, and has [[antifungal medication\|antifungal]] and [[antibiotic]] properties as well. Whether CCD-X will be useful in [[sickle cell disease]] (releasing NO) is unknown. Further basic and clinical research are needed before the effects of Burantashi can be effectively evaluated.		Burantashi is used as a food additive to barbecued meat (suya) in [[Nigeria]], especially the Northern parts. The extracts contain the [[alkaloid]] [[yohimbine]], an [[Alpha-2 adrenergic receptor\|alpha-<sub>2</sub>]] [[receptor antagonist\|antagonist]] that has been used widely with variable success in [[erectile dysfunction]], but the whole bark of the tree was not studied until recently. In one recent study, pure Burantashi powder obtained from a local suya vendor in [[Lagos, Nigeria]] was extracted aqueously and studied on the renal circulation of [[Sprague-Dawley rat]]s.<ref name=Ajayi>Ajayi AA, Newaz M, Hercule H, Saleh M, Bode CO, Oyekan AO. Endothelin -like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague-Dawley rats. ''Methods. Find. Expt. Clin. Pharmacol''. 2003, 25(10): 817-22.</ref> In the ''in vivo'' study, the extract code-named "CCD-X", caused a rise in [[mean arterial pressure]] (MAP), and a rise in [[renal medulla]]ry blood flow (MBF). This systemic [[vasoconstrictor]] and renal medullary dilator action was attenuated separately by the endothelin -A receptor blocker - BMS-182874, ET-B blocker -BQ788, but blocked by their combination.<ref name=Ajayi/> Further, the [[nitric oxide]] inhibitor (NO), L-Nomega - nitro-Arginine Methyl Ester (L-NAME) 10 mg/kg totally inhibited the rise in medullary blood flow due to CCD-X. ''In vitro'' studies in isolated perfused kidneys (IPK) and in pressurised microvessels (PMV) confirmed the ''in vivo'' effect to cause [[vasoconstriction]], which was inhibited by [[endothelin]] A and B antagonists. The pressor dose response characteristic of CCD-X on PMV was similar to that of endothelin-1 with EC<sub>50</sub> close to 100 ng. It was concluded from these studies that, the aqueous extract exhibited a vasoconstrictor effect -possibly alpha-<sub>2</sub> mediated like yohimbine. However, it possessed additional effects as an andothelin receptor A and B agonist, and also released nitric oxide. The possibility of a post-receptor cross-talk among ET-B, alpha-2 receptors and NO release was also considered. [[Thin layer chromatography]] showed that the bark is rich in [[sesquiterpene]]s, and has [[antifungal medication\|antifungal]] and [[antibiotic]] properties as well. Whether CCD-X will be useful in [[sickle cell disease]] (releasing NO) is unknown. Further basic and clinical research are needed before the effects of Burantashi can be effectively evaluated.

Iamdiran at 22:21, 29 July 2018

2018-07-29T22:21:22Z

← Previous revision		Revision as of 22:21, 29 July 2018
Line 4:		Line 4:
	}}		}}

	'''Burantashi''' (literally "penis get up") is a native [[Hausa people\|Hausa]]-[[Fulani]] powder derived from the bark of the African tree ''[[Pausinystalia yohimbe]]''.		'''Burantashi''' (literally "penis get up") is a native [[Hausa people\|Hausa]]-[[Fulani]] powder derived from the bark of the African tree ''[[Pausinystalia yohimbe]]''.

	Burantashi is used as a food additive to barbecued meat (suya) in [[Nigeria]], especially the Northern parts. The extracts contain the [[alkaloid]] [[yohimbine]], an [[Alpha-2 adrenergic receptor\|alpha-<sub>2</sub>]] [[receptor antagonist\|antagonist]] that has been used widely with variable success in [[erectile dysfunction]], but the whole bark of the tree was not studied until recently. In one recent study, pure Burantashi powder obtained from a local suya vendor in [[Lagos, Nigeria]] was extracted aqueously and studied on the renal circulation of [[Sprague-Dawley rat]]s.<ref name=Ajayi>Ajayi AA, Newaz M, Hercule H, Saleh M, Bode CO, Oyekan AO. Endothelin -like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague-Dawley rats. ''Methods. Find. Expt. Clin. Pharmacol''. 2003, 25(10): 817-22.</ref> In the ''in vivo'' study, the extract code-named "CCD-X", caused a rise in [[mean arterial pressure]] (MAP), and a rise in [[renal medulla]]ry blood flow (MBF). This systemic [[vasoconstrictor]] and renal medullary dilator action was attenuated separately by the endothelin -A receptor blocker - BMS-182874, ET-B blocker -BQ788, but blocked by their combination.<ref name=Ajayi/> Further, the [[nitric oxide]] inhibitor (NO), L-Nomega - nitro-Arginine Methyl Ester (L-NAME) 10 mg/kg totally inhibited the rise in medullary blood flow due to CCD-X. ''In vitro'' studies in isolated perfused kidneys (IPK) and in pressurised microvessels (PMV) confirmed the ''in vivo'' effect to cause [[vasoconstriction]], which was inhibited by [[endothelin]] A and B antagonists. The pressor dose response characteristic of CCD-X on PMV was similar to that of endothelin-1 with EC<sub>50</sub> close to 100 ng. It was concluded from these studies that, the aqueous extract exhibited a vasoconstrictor effect -possibly alpha-<sub>2</sub> mediated like yohimbine. However, it possessed additional effects as an andothelin receptor A and B agonist, and also released nitric oxide. The possibility of a post-receptor cross-talk among ET-B, alpha-2 receptors and NO release was also considered. [[Thin layer chromatography]] showed that the bark is rich in [[sesquiterpene]]s, and has [[antifungal medication\|antifungal]] and [[antibiotic]] properties as well. Whether CCD-X will be useful in [[sickle cell disease]] (releasing NO) is unknown. Further basic and clinical research are needed before the effects of Burantashi can be effectively evaluated.		Burantashi is used as a food additive to barbecued meat (suya) in [[Nigeria]], especially the Northern parts. The extracts contain the [[alkaloid]] [[yohimbine]], an [[Alpha-2 adrenergic receptor\|alpha-<sub>2</sub>]] [[receptor antagonist\|antagonist]] that has been used widely with variable success in [[erectile dysfunction]], but the whole bark of the tree was not studied until recently. In one recent study, pure Burantashi powder obtained from a local suya vendor in [[Lagos, Nigeria]] was extracted aqueously and studied on the renal circulation of [[Sprague-Dawley rat]]s.<ref name=Ajayi>Ajayi AA, Newaz M, Hercule H, Saleh M, Bode CO, Oyekan AO. Endothelin -like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague-Dawley rats. ''Methods. Find. Expt. Clin. Pharmacol''. 2003, 25(10): 817-22.</ref> In the ''in vivo'' study, the extract code-named "CCD-X", caused a rise in [[mean arterial pressure]] (MAP), and a rise in [[renal medulla]]ry blood flow (MBF). This systemic [[vasoconstrictor]] and renal medullary dilator action was attenuated separately by the endothelin -A receptor blocker - BMS-182874, ET-B blocker -BQ788, but blocked by their combination.<ref name=Ajayi/> Further, the [[nitric oxide]] inhibitor (NO), L-Nomega - nitro-Arginine Methyl Ester (L-NAME) 10 mg/kg totally inhibited the rise in medullary blood flow due to CCD-X. ''In vitro'' studies in isolated perfused kidneys (IPK) and in pressurised microvessels (PMV) confirmed the ''in vivo'' effect to cause [[vasoconstriction]], which was inhibited by [[endothelin]] A and B antagonists. The pressor dose response characteristic of CCD-X on PMV was similar to that of endothelin-1 with EC<sub>50</sub> close to 100 ng. It was concluded from these studies that, the aqueous extract exhibited a vasoconstrictor effect -possibly alpha-<sub>2</sub> mediated like yohimbine. However, it possessed additional effects as an andothelin receptor A and B agonist, and also released nitric oxide. The possibility of a post-receptor cross-talk among ET-B, alpha-2 receptors and NO release was also considered. [[Thin layer chromatography]] showed that the bark is rich in [[sesquiterpene]]s, and has [[antifungal medication\|antifungal]] and [[antibiotic]] properties as well. Whether CCD-X will be useful in [[sickle cell disease]] (releasing NO) is unknown. Further basic and clinical research are needed before the effects of Burantashi can be effectively evaluated.

InternetArchiveBot: Rescuing 1 sources and tagging 0 as dead. #IABot (v1.5beta)

2017-07-27T14:57:49Z

Rescuing 1 sources and tagging 0 as dead. #IABot (v1.5beta)

← Previous revision		Revision as of 14:57, 27 July 2017
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	==External links==		==External links==
	* [https://web.archive.org/web/20060822150629/http://www.sunnewsonline.com~~:80~~/webpages/features/travels/2004/dec/30/travels-30-12-2004-001.htm Article in the Daily Sun newspaper of Nigeria]		* [https://web.archive.org/web/20060822150629/http://www.sunnewsonline.com/webpages/features/travels/2004/dec/30/travels-30-12-2004-001.htm Article in the Daily Sun newspaper of Nigeria]

	[[Category:Traditional African medicine]]		[[Category:Traditional African medicine]]

← Previous revision		Revision as of 09:06, 4 December 2022
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			{{merge to\|Corynanthe johimbe\|discuss=Talk:Corynanthe johimbe#Merger proposal\|date=December 2022}}
	{{multiple issues\|		{{multiple issues\|
	{{more medical citations needed\|date=February 2014}}		{{more medical citations needed\|date=February 2014}}

← Previous revision		Revision as of 08:32, 15 March 2022
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	{{multiple issues\|		{{multiple issues\|
	{{~~medref~~\|date=February 2014}}		{{more medical citations needed\|date=February 2014}}
	{{~~refimprove~~\|date=March 2009}}		{{more citations needed\|date=March 2009}}
	{{technical\|date=July 2019}}		{{technical\|date=July 2019}}
			{{Orphan\|date=March 2022}}
	}}		}}

	'''Burantashi''' (literally "penis get up") is a native [[Hausa people\|Hausa]]-[[Fulani]] powder derived from the bark of the African tree ''[[Pausinystalia johimbe]]''.		'''Burantashi''' (literally "penis get up") is a native [[Hausa people\|Hausa]]-[[Fulani]] powder derived from the bark of the African tree ''[[Pausinystalia johimbe]]''.

	Burantashi is used as a food additive to barbecued meat (suya) in [[Nigeria]], especially the Northern parts. The extracts contain the [[alkaloid]] [[yohimbine]], an [[Alpha-2 adrenergic receptor\|alpha-<sub>2</sub>]] [[receptor antagonist\|antagonist]] that has been studied for treating [[erectile dysfunction]], but the whole bark of the tree was not studied until recently. In one recent study, pure Burantashi powder obtained from a local suya vendor in [[Lagos, Nigeria]] was extracted aqueously and studied on the renal circulation of [[Sprague-Dawley rat]]s.<ref name=Ajayi>Ajayi AA, Newaz M, Hercule H, Saleh M, Bode CO, Oyekan AO. Endothelin -like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague-Dawley rats. ''Methods. Find. Expt. Clin. Pharmacol''. 2003, 25(10): 817-22.</ref> In the ''in vivo'' study, the extract code-named "CCD-X", caused a rise in [[mean arterial pressure]] (MAP), and a rise in [[renal medulla]]ry blood flow (MBF). This systemic [[vasoconstrictor]] and renal medullary dilator action was attenuated separately by the endothelin -A receptor blocker - BMS-182874, ET-B blocker -BQ788, but blocked by their combination.<ref name=Ajayi/> Further, the [[nitric oxide]] inhibitor (NO), L-Nomega - nitro-Arginine Methyl Ester (L-NAME) 10 mg/kg totally inhibited the rise in medullary blood flow due to CCD-X. ''In vitro'' studies in isolated perfused kidneys (IPK) and in pressurised microvessels (PMV) confirmed the ''in vivo'' effect to cause [[vasoconstriction]], which was inhibited by [[endothelin]] A and B antagonists. The pressor dose response characteristic of CCD-X on PMV was similar to that of endothelin-1 with EC<sub>50</sub> close to 100 ng. It was concluded from these studies that, the aqueous extract exhibited a vasoconstrictor effect -possibly alpha-<sub>2</sub> mediated like yohimbine. However, it possessed additional effects as an andothelin receptor A and B agonist, and also released nitric oxide. The possibility of a post-receptor cross-talk among ET-B, alpha-2 receptors and NO release was also considered. [[Thin layer chromatography]] showed that the bark is rich in [[sesquiterpene]]s, and has [[antifungal medication\|antifungal]] and [[antibiotic]] properties as well. Whether CCD-X will be useful in [[sickle cell disease]] (releasing NO) is unknown. Further basic and clinical research are needed before the effects of Burantashi can be effectively evaluated.		Burantashi is used as a food additive to barbecued meat (suya) in [[Nigeria]], especially the Northern parts. The extracts contain the [[alkaloid]] [[yohimbine]], an [[Alpha-2 adrenergic receptor\|alpha-<sub>2</sub>]] [[receptor antagonist\|antagonist]] that has been studied for treating [[erectile dysfunction]], but the whole bark of the tree was not studied until recently. In one recent study, pure Burantashi powder obtained from a local suya vendor in [[Lagos, Nigeria]] was extracted aqueously and studied on the renal circulation of [[Sprague-Dawley rat]]s.<ref name=Ajayi>Ajayi AA, Newaz M, Hercule H, Saleh M, Bode CO, Oyekan AO. Endothelin -like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague-Dawley rats. ''Methods. Find. Expt. Clin. Pharmacol''. 2003, 25(10): 817-22.</ref> In the ''in vivo'' study, the extract code-named "CCD-X", caused a rise in [[mean arterial pressure]] (MAP), and a rise in [[renal medulla]]ry blood flow (MBF). This systemic [[vasoconstrictor]] and renal medullary dilator action was attenuated separately by the endothelin -A receptor blocker - BMS-182874, ET-B blocker -BQ788, but blocked by their combination.<ref name=Ajayi/> Further, the [[nitric oxide]] inhibitor (NO), L-Nomega - nitro-Arginine Methyl Ester (L-NAME) 10 mg/kg totally inhibited the rise in medullary blood flow due to CCD-X. ''In vitro'' studies in isolated perfused kidneys (IPK) and in pressurised microvessels (PMV) confirmed the ''in vivo'' effect to cause [[vasoconstriction]], which was inhibited by [[endothelin]] A and B antagonists. The pressor dose response characteristic of CCD-X on PMV was similar to that of endothelin-1 with EC<sub>50</sub> close to 100 ng. It was concluded from these studies that, the aqueous extract exhibited a vasoconstrictor effect -possibly alpha-<sub>2</sub> mediated like yohimbine. However, it possessed additional effects as an andothelin receptor A and B agonist, and also released nitric oxide. The possibility of a post-receptor cross-talk among ET-B, alpha-2 receptors and NO release was also considered. [[Thin layer chromatography]] showed that the bark is rich in [[sesquiterpene]]s, and has [[antifungal medication\|antifungal]] and [[antibiotic]] properties as well. Whether CCD-X will be useful in [[sickle cell disease]] (releasing NO) is unknown. Further basic and clinical research are needed before the effects of Burantashi can be effectively evaluated.