Hypoglycin A - Revision history

OAbot: Open access bot: doi updated in citation with #oabot.

2023-11-27T21:19:38Z

Open access bot: doi updated in citation with #oabot.

← Previous revision		Revision as of 21:19, 27 November 2023
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	'''Hypoglycin A''' is a naturally occurring [[amino acid]] derivative found in the unripened fruit of the [[Ackee]] tree (''[[Blighia sapida]]'')<ref name="medscape">{{cite journal \| url = http://emedicine.medscape.com/article/1008792-overview \| title = Ackee Fruit Toxicity \| website = [[Medscape]]\| date = 2018-06-13 }}</ref> and in the seeds of the box elder tree (''[[Acer negundo]]'').<ref name="Valberg2013">{{Cite journal\|last1=Valberg\|first1=S. J.\|last2=Sponseller\|first2=B. T.\|last3=Hegeman\|first3=A. D.\|last4=Earing\|first4=J.\|last5=Bender\|first5=J. B.\|last6=Martinson\|first6=K. L.\|last7=Patterson\|first7=S. E.\|last8=Sweetman\|first8=L.\|date=2013-07-01\|title=Seasonal pasture myopathy/atypical myopathy in North America associated with ingestion of hypoglycin A within seeds of the box elder tree\|journal=Equine Veterinary Journal\|language=en\|volume=45\|issue=4\|pages=419–426\|doi=10.1111/j.2042-3306.2012.00684.x\|pmid=23167695\|s2cid=206002430 \|issn=2042-3306}}</ref> It is toxic if ingested, and is the causative agent of [[Jamaican vomiting sickness]].<ref name="medscape"/> A 2017 Lancet report established a link between the consumption of unripened lychees (containing hypoglycin A or methylenecyclopropylglycine (MCPG)) resulting in hypoglycaemia and death from acute toxic encephalopathy.<ref>{{cite journal\|last1=Shrivastava\|first1=Aakash\|title=Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study\|journal=The Lancet Global Health\|volume=5\|issue=4\|pages=e458–e466\|doi=10.1016/S2214-109X(17)30035-9\|pmid=28153514\|year=2017\|doi-access=free}}</ref>		'''Hypoglycin A''' is a naturally occurring [[amino acid]] derivative found in the unripened fruit of the [[Ackee]] tree (''[[Blighia sapida]]'')<ref name="medscape">{{cite journal \| url = http://emedicine.medscape.com/article/1008792-overview \| title = Ackee Fruit Toxicity \| website = [[Medscape]]\| date = 2018-06-13 }}</ref> and in the seeds of the box elder tree (''[[Acer negundo]]'').<ref name="Valberg2013">{{Cite journal\|last1=Valberg\|first1=S. J.\|last2=Sponseller\|first2=B. T.\|last3=Hegeman\|first3=A. D.\|last4=Earing\|first4=J.\|last5=Bender\|first5=J. B.\|last6=Martinson\|first6=K. L.\|last7=Patterson\|first7=S. E.\|last8=Sweetman\|first8=L.\|date=2013-07-01\|title=Seasonal pasture myopathy/atypical myopathy in North America associated with ingestion of hypoglycin A within seeds of the box elder tree\|journal=Equine Veterinary Journal\|language=en\|volume=45\|issue=4\|pages=419–426\|doi=10.1111/j.2042-3306.2012.00684.x\|pmid=23167695\|s2cid=206002430 \|issn=2042-3306\|doi-access=free}}</ref> It is toxic if ingested, and is the causative agent of [[Jamaican vomiting sickness]].<ref name="medscape"/> A 2017 Lancet report established a link between the consumption of unripened lychees (containing hypoglycin A or methylenecyclopropylglycine (MCPG)) resulting in hypoglycaemia and death from acute toxic encephalopathy.<ref>{{cite journal\|last1=Shrivastava\|first1=Aakash\|title=Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study\|journal=The Lancet Global Health\|volume=5\|issue=4\|pages=e458–e466\|doi=10.1016/S2214-109X(17)30035-9\|pmid=28153514\|year=2017\|doi-access=free}}</ref>

	==Sources==		==Sources==

KoIobok: Changed Category:Amino acids to Category:Alpha-Amino acids

2023-09-17T16:49:17Z

Changed Category:Amino acids to Category:Alpha-Amino acids

← Previous revision		Revision as of 16:49, 17 September 2023
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	{{reflist}}		{{reflist}}

	[[Category:Amino acids]]		[[Category:Alpha-Amino acids]]
	[[Category:Cyclopropanes]]		[[Category:Cyclopropanes]]
	[[Category:Toxic amino acids]]		[[Category:Toxic amino acids]]

Onel5969: Disambiguating links to Homology (link changed to Homologous series) using DisamAssist.

2023-08-27T18:46:25Z

Disambiguating links to Homology (link changed to Homologous series) using DisamAssist.

← Previous revision		Revision as of 18:46, 27 August 2023
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	The entirety of the unripe Ackee fruit is toxic and contains large amounts of hypoglycin. The fruit is safe to eat only when the fruit is allowed to fully open and expose the large black seeds while on the tree. The levels of the toxin decrease over time though from approximately 1000 ppm to around 0.1 ppm in the mature fruit.<ref name = scq>{{cite web \| url = http://www.scq.ubc.ca/the-ackee-fruit-blighia-sapida-and-its-associated-toxic-effects/ \| title = THE ACKEE FRUIT (BLIGHIA SAPIDA) AND ITS ASSOCIATED TOXIC EFFECTS \| publisher = [[University of British Columbia]]\| date = 2005-11-17 }}</ref>		The entirety of the unripe Ackee fruit is toxic and contains large amounts of hypoglycin. The fruit is safe to eat only when the fruit is allowed to fully open and expose the large black seeds while on the tree. The levels of the toxin decrease over time though from approximately 1000 ppm to around 0.1 ppm in the mature fruit.<ref name = scq>{{cite web \| url = http://www.scq.ubc.ca/the-ackee-fruit-blighia-sapida-and-its-associated-toxic-effects/ \| title = THE ACKEE FRUIT (BLIGHIA SAPIDA) AND ITS ASSOCIATED TOXIC EFFECTS \| publisher = [[University of British Columbia]]\| date = 2005-11-17 }}</ref>

	Relatives of Ackee, including [[lychee]], [[longan]], and [[rambutan]], can contain enough α-(methylenecyclopropyl)glycine, a [[~~Homology~~ ~~(chemistry)~~\|homologue]] of hypoglycin A, in their fruit to cause [[hypoglycemic]] [[encephalopathy]] in undernourished children, when consumed in large quantities.<ref name="EID">{{citation \|author1=Spencer, P. S. \|author2=Palmer, V. S. \|author3=Mazumder, R. \|journal=[[Emerging Infectious Diseases]] \|title=Probable Toxic Cause for Suspected Lychee-Linked Viral Encephalitis \|year=2015 \|volume=21 \|issue=5 \|pages=904–5 \|doi=10.3201/eid2105.141650\|pmid=25897979 \|pmc=4412228 }}</ref>		Relatives of Ackee, including [[lychee]], [[longan]], and [[rambutan]], can contain enough α-(methylenecyclopropyl)glycine, a [[Homologous series\|homologue]] of hypoglycin A, in their fruit to cause [[hypoglycemic]] [[encephalopathy]] in undernourished children, when consumed in large quantities.<ref name="EID">{{citation \|author1=Spencer, P. S. \|author2=Palmer, V. S. \|author3=Mazumder, R. \|journal=[[Emerging Infectious Diseases]] \|title=Probable Toxic Cause for Suspected Lychee-Linked Viral Encephalitis \|year=2015 \|volume=21 \|issue=5 \|pages=904–5 \|doi=10.3201/eid2105.141650\|pmid=25897979 \|pmc=4412228 }}</ref>

	==Toxicity==		==Toxicity==

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2023-08-08T05:43:53Z

Add: s2cid. | Use this bot. Report bugs. | Suggested by Abductive | Category:Toxic amino acids | #UCB_Category 10/20

← Previous revision		Revision as of 05:43, 8 August 2023
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	}}		}}

	'''Hypoglycin A''' is a naturally occurring [[amino acid]] derivative found in the unripened fruit of the [[Ackee]] tree (''[[Blighia sapida]]'')<ref name="medscape">{{cite journal \| url = http://emedicine.medscape.com/article/1008792-overview \| title = Ackee Fruit Toxicity \| website = [[Medscape]]\| date = 2018-06-13 }}</ref> and in the seeds of the box elder tree (''[[Acer negundo]]'').<ref name="Valberg2013">{{Cite journal\|last1=Valberg\|first1=S. J.\|last2=Sponseller\|first2=B. T.\|last3=Hegeman\|first3=A. D.\|last4=Earing\|first4=J.\|last5=Bender\|first5=J. B.\|last6=Martinson\|first6=K. L.\|last7=Patterson\|first7=S. E.\|last8=Sweetman\|first8=L.\|date=2013-07-01\|title=Seasonal pasture myopathy/atypical myopathy in North America associated with ingestion of hypoglycin A within seeds of the box elder tree\|journal=Equine Veterinary Journal\|language=en\|volume=45\|issue=4\|pages=419–426\|doi=10.1111/j.2042-3306.2012.00684.x\|pmid=23167695\|issn=2042-3306}}</ref> It is toxic if ingested, and is the causative agent of [[Jamaican vomiting sickness]].<ref name="medscape"/> A 2017 Lancet report established a link between the consumption of unripened lychees (containing hypoglycin A or methylenecyclopropylglycine (MCPG)) resulting in hypoglycaemia and death from acute toxic encephalopathy.<ref>{{cite journal\|last1=Shrivastava\|first1=Aakash\|title=Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study\|journal=The Lancet Global Health\|volume=5\|issue=4\|pages=e458–e466\|doi=10.1016/S2214-109X(17)30035-9\|pmid=28153514\|year=2017\|doi-access=free}}</ref>		'''Hypoglycin A''' is a naturally occurring [[amino acid]] derivative found in the unripened fruit of the [[Ackee]] tree (''[[Blighia sapida]]'')<ref name="medscape">{{cite journal \| url = http://emedicine.medscape.com/article/1008792-overview \| title = Ackee Fruit Toxicity \| website = [[Medscape]]\| date = 2018-06-13 }}</ref> and in the seeds of the box elder tree (''[[Acer negundo]]'').<ref name="Valberg2013">{{Cite journal\|last1=Valberg\|first1=S. J.\|last2=Sponseller\|first2=B. T.\|last3=Hegeman\|first3=A. D.\|last4=Earing\|first4=J.\|last5=Bender\|first5=J. B.\|last6=Martinson\|first6=K. L.\|last7=Patterson\|first7=S. E.\|last8=Sweetman\|first8=L.\|date=2013-07-01\|title=Seasonal pasture myopathy/atypical myopathy in North America associated with ingestion of hypoglycin A within seeds of the box elder tree\|journal=Equine Veterinary Journal\|language=en\|volume=45\|issue=4\|pages=419–426\|doi=10.1111/j.2042-3306.2012.00684.x\|pmid=23167695\|s2cid=206002430 \|issn=2042-3306}}</ref> It is toxic if ingested, and is the causative agent of [[Jamaican vomiting sickness]].<ref name="medscape"/> A 2017 Lancet report established a link between the consumption of unripened lychees (containing hypoglycin A or methylenecyclopropylglycine (MCPG)) resulting in hypoglycaemia and death from acute toxic encephalopathy.<ref>{{cite journal\|last1=Shrivastava\|first1=Aakash\|title=Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study\|journal=The Lancet Global Health\|volume=5\|issue=4\|pages=e458–e466\|doi=10.1016/S2214-109X(17)30035-9\|pmid=28153514\|year=2017\|doi-access=free}}</ref>

	==Sources==		==Sources==

LegionMammal978: add semisystematic name

2023-05-02T18:26:22Z

add semisystematic name

← Previous revision		Revision as of 18:26, 2 May 2023
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	\| ImageSize = 200px		\| ImageSize = 200px
	\| ImageName = Hypoglycin		\| ImageName = Hypoglycin
	\| ~~PIN~~ = ~~(2''S'')-2-Amino-~~3-[(1''R'')-2-~~methylidenecyclopropyl~~]~~propanoic acid~~		\| IUPACName = 3-[(1''R''-2-Methylidenecyclopropyl]-<small>L</small>-alanine
			\| SystematicName = (2''S'')-2-Amino-3-[(1''R'')-2-methylidenecyclopropyl]propanoic acid
	\| OtherNames = Hypoglycin A; Hypoglycine; 2-Methylenecyclopropanylalanine		\| OtherNames = Hypoglycin A; Hypoglycine; 2-Methylenecyclopropanylalanine
	\| Section1 = {{Chembox Identifiers		\| Section1 = {{Chembox Identifiers

Trappist the monk: /* top */parameter misuse;

2022-08-22T13:09:47Z

top: parameter misuse;

← Previous revision		Revision as of 13:09, 22 August 2022
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	}}		}}

	'''Hypoglycin A''' is a naturally occurring [[amino acid]] derivative found in the unripened fruit of the [[Ackee]] tree (''[[Blighia sapida]]'')<ref name="medscape">{{cite journal \| url = http://emedicine.medscape.com/article/1008792-overview \| title = Ackee Fruit Toxicity \| website = [[Medscape]]\| date = 2018-06-13 }}</ref> and in the seeds of the box elder tree (''[[Acer negundo]]'').<ref name="Valberg2013">{{Cite journal\|last1=Valberg\|first1=S. J.\|last2=Sponseller\|first2=B. T.\|last3=Hegeman\|first3=A. D.\|last4=Earing\|first4=J.\|last5=Bender\|first5=J. B.\|last6=Martinson\|first6=K. L.\|last7=Patterson\|first7=S. E.\|last8=Sweetman\|first8=L.\|date=2013-07-01\|title=Seasonal pasture myopathy/atypical myopathy in North America associated with ingestion of hypoglycin A within seeds of the box elder tree\|journal=Equine Veterinary Journal\|language=en\|volume=45\|issue=4\|pages=419–426\|doi=10.1111/j.2042-3306.2012.00684.x\|pmid=23167695\|issn=2042-3306}}</ref> It is toxic if ingested, and is the causative agent of [[Jamaican vomiting sickness]].<ref name="medscape"/> A 2017 Lancet report established a link between the consumption of unripened lychees (containing hypoglycin A or methylenecyclopropylglycine (MCPG)) resulting in hypoglycaemia and death from acute toxic encephalopathy.<ref>{{cite journal\|last1=Shrivastava\|first1=Aakash\|title=Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study\|journal=The Lancet Global Health\|volume=5\|issue=4\|pages=e458–e466~~\|ref=http://dx.doi.org/10.1016/S2214-109X(17)30035-9~~\|doi=10.1016/S2214-109X(17)30035-9\|pmid=28153514\|year=2017\|doi-access=free}}</ref>		'''Hypoglycin A''' is a naturally occurring [[amino acid]] derivative found in the unripened fruit of the [[Ackee]] tree (''[[Blighia sapida]]'')<ref name="medscape">{{cite journal \| url = http://emedicine.medscape.com/article/1008792-overview \| title = Ackee Fruit Toxicity \| website = [[Medscape]]\| date = 2018-06-13 }}</ref> and in the seeds of the box elder tree (''[[Acer negundo]]'').<ref name="Valberg2013">{{Cite journal\|last1=Valberg\|first1=S. J.\|last2=Sponseller\|first2=B. T.\|last3=Hegeman\|first3=A. D.\|last4=Earing\|first4=J.\|last5=Bender\|first5=J. B.\|last6=Martinson\|first6=K. L.\|last7=Patterson\|first7=S. E.\|last8=Sweetman\|first8=L.\|date=2013-07-01\|title=Seasonal pasture myopathy/atypical myopathy in North America associated with ingestion of hypoglycin A within seeds of the box elder tree\|journal=Equine Veterinary Journal\|language=en\|volume=45\|issue=4\|pages=419–426\|doi=10.1111/j.2042-3306.2012.00684.x\|pmid=23167695\|issn=2042-3306}}</ref> It is toxic if ingested, and is the causative agent of [[Jamaican vomiting sickness]].<ref name="medscape"/> A 2017 Lancet report established a link between the consumption of unripened lychees (containing hypoglycin A or methylenecyclopropylglycine (MCPG)) resulting in hypoglycaemia and death from acute toxic encephalopathy.<ref>{{cite journal\|last1=Shrivastava\|first1=Aakash\|title=Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study\|journal=The Lancet Global Health\|volume=5\|issue=4\|pages=e458–e466\|doi=10.1016/S2214-109X(17)30035-9\|pmid=28153514\|year=2017\|doi-access=free}}</ref>

	==Sources==		==Sources==

DePiep: GHS update: remove empty EUClass/Rphrase/Sphrase parameters (depr), replaced: | RPhrases = | → |

2021-12-12T13:16:39Z

GHS update: remove empty EUClass/Rphrase/Sphrase parameters (depr), replaced: | RPhrases = | → |

← Previous revision		Revision as of 13:16, 12 December 2021
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	\| MainHazards =		\| MainHazards =
	\| FlashPt =		\| FlashPt =
			}}
	\| RPhrases =
	\| SPhrases = }}
	}}		}}

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	==Sources==		==Sources==
	The entirety of the unripe Ackee fruit is toxic and contains large amounts of hypoglycin. The fruit is safe to eat only when the fruit is allowed to fully open and expose the large black seeds while on the tree. The levels of the toxin decrease over time though from approximately 1000 ppm to around 0.1 ppm in the mature fruit.<ref name = scq>{{cite web \| url = http://www.scq.ubc.ca/the-ackee-fruit-blighia-sapida-and-its-associated-toxic-effects/ \| title = THE ACKEE FRUIT (BLIGHIA SAPIDA) AND ITS ASSOCIATED TOXIC EFFECTS \| publisher = [[University of British Columbia]]\| date = 2005-11-17 }}</ref>		The entirety of the unripe Ackee fruit is toxic and contains large amounts of hypoglycin. The fruit is safe to eat only when the fruit is allowed to fully open and expose the large black seeds while on the tree. The levels of the toxin decrease over time though from approximately 1000 ppm to around 0.1 ppm in the mature fruit.<ref name = scq>{{cite web \| url = http://www.scq.ubc.ca/the-ackee-fruit-blighia-sapida-and-its-associated-toxic-effects/ \| title = THE ACKEE FRUIT (BLIGHIA SAPIDA) AND ITS ASSOCIATED TOXIC EFFECTS \| publisher = [[University of British Columbia]]\| date = 2005-11-17 }}</ref>

	Relatives of Ackee, including [[lychee]], [[longan]], and [[rambutan]], can contain enough α-(methylenecyclopropyl)glycine, a [[Homology (chemistry)\|homologue]] of hypoglycin A, in their fruit to cause [[hypoglycemic]] [[encephalopathy]] in undernourished children, when consumed in large quantities.<ref name="EID">{{citation \|author1=Spencer, P. S. \|author2=Palmer, V. S. \|author3=Mazumder, R. \|journal=[[Emerging Infectious Diseases]] \|title=Probable Toxic Cause for Suspected Lychee-Linked Viral Encephalitis \|year=2015 \|volume=21 \|issue=5 \|pages=904–5 \|doi=10.3201/eid2105.141650\|pmid=25897979 \|pmc=4412228 }}</ref>		Relatives of Ackee, including [[lychee]], [[longan]], and [[rambutan]], can contain enough α-(methylenecyclopropyl)glycine, a [[Homology (chemistry)\|homologue]] of hypoglycin A, in their fruit to cause [[hypoglycemic]] [[encephalopathy]] in undernourished children, when consumed in large quantities.<ref name="EID">{{citation \|author1=Spencer, P. S. \|author2=Palmer, V. S. \|author3=Mazumder, R. \|journal=[[Emerging Infectious Diseases]] \|title=Probable Toxic Cause for Suspected Lychee-Linked Viral Encephalitis \|year=2015 \|volume=21 \|issue=5 \|pages=904–5 \|doi=10.3201/eid2105.141650\|pmid=25897979 \|pmc=4412228 }}</ref>
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	[[Category:Cyclopropanes]]		[[Category:Cyclopropanes]]
	[[Category:Toxic amino acids]]		[[Category:Toxic amino acids]]
	[[Category:~~plant~~ toxins]]		[[Category:Plant toxins]]

Citation bot: Alter: template type. Removed proxy/dead URL that duplicated identifier. Removed access-date with no URL. | Use this bot. Report bugs. | Suggested by Whoop whoop pull up | #UCB_webform 3/3

2021-08-11T01:32:39Z

Alter: template type. Removed proxy/dead URL that duplicated identifier. Removed access-date with no URL. | Use this bot. Report bugs. | Suggested by Whoop whoop pull up | #UCB_webform 3/3

← Previous revision		Revision as of 01:32, 11 August 2021
Line 53:		Line 53:
	}}		}}

	'''Hypoglycin A''' is a naturally occurring [[amino acid]] derivative found in the unripened fruit of the [[Ackee]] tree (''[[Blighia sapida]]'')<ref name="medscape">{{cite ~~web~~ \| url = http://emedicine.medscape.com/article/1008792-overview \| title = Ackee Fruit Toxicity \| website = [[Medscape]]\| date = 2018-06-13 }}</ref> and in the seeds of the box elder tree (''[[Acer negundo]]'').<ref name="Valberg2013">{{Cite journal\|last1=Valberg\|first1=S. J.\|last2=Sponseller\|first2=B. T.\|last3=Hegeman\|first3=A. D.\|last4=Earing\|first4=J.\|last5=Bender\|first5=J. B.\|last6=Martinson\|first6=K. L.\|last7=Patterson\|first7=S. E.\|last8=Sweetman\|first8=L.\|date=2013-07-01\|title=Seasonal pasture myopathy/atypical myopathy in North America associated with ingestion of hypoglycin A within seeds of the box elder tree\|journal=Equine Veterinary Journal\|language=en\|volume=45\|issue=4\|pages=419–426\|doi=10.1111/j.2042-3306.2012.00684.x\|pmid=23167695\|issn=2042-3306}}</ref> It is toxic if ingested, and is the causative agent of [[Jamaican vomiting sickness]].<ref name="medscape"/> A 2017 Lancet report established a link between the consumption of unripened lychees (containing hypoglycin A or methylenecyclopropylglycine (MCPG)) resulting in hypoglycaemia and death from acute toxic encephalopathy.<ref>{{cite journal\|last1=Shrivastava\|first1=Aakash\|title=Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study~~\|url=http://www.thelancet.com/journals/langlo/article/PIIS2214-109X(17)30035-9/fulltext?rss=yes~~\|journal=The Lancet Global Health\|volume=5\|issue=4\|pages=e458–e466~~\|access-date=1 February 2017~~\|ref=http://dx.doi.org/10.1016/S2214-109X(17)30035-9\|doi=10.1016/S2214-109X(17)30035-9\|pmid=28153514\|year=2017\|doi-access=free}}</ref>		'''Hypoglycin A''' is a naturally occurring [[amino acid]] derivative found in the unripened fruit of the [[Ackee]] tree (''[[Blighia sapida]]'')<ref name="medscape">{{cite journal \| url = http://emedicine.medscape.com/article/1008792-overview \| title = Ackee Fruit Toxicity \| website = [[Medscape]]\| date = 2018-06-13 }}</ref> and in the seeds of the box elder tree (''[[Acer negundo]]'').<ref name="Valberg2013">{{Cite journal\|last1=Valberg\|first1=S. J.\|last2=Sponseller\|first2=B. T.\|last3=Hegeman\|first3=A. D.\|last4=Earing\|first4=J.\|last5=Bender\|first5=J. B.\|last6=Martinson\|first6=K. L.\|last7=Patterson\|first7=S. E.\|last8=Sweetman\|first8=L.\|date=2013-07-01\|title=Seasonal pasture myopathy/atypical myopathy in North America associated with ingestion of hypoglycin A within seeds of the box elder tree\|journal=Equine Veterinary Journal\|language=en\|volume=45\|issue=4\|pages=419–426\|doi=10.1111/j.2042-3306.2012.00684.x\|pmid=23167695\|issn=2042-3306}}</ref> It is toxic if ingested, and is the causative agent of [[Jamaican vomiting sickness]].<ref name="medscape"/> A 2017 Lancet report established a link between the consumption of unripened lychees (containing hypoglycin A or methylenecyclopropylglycine (MCPG)) resulting in hypoglycaemia and death from acute toxic encephalopathy.<ref>{{cite journal\|last1=Shrivastava\|first1=Aakash\|title=Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study\|journal=The Lancet Global Health\|volume=5\|issue=4\|pages=e458–e466\|ref=http://dx.doi.org/10.1016/S2214-109X(17)30035-9\|doi=10.1016/S2214-109X(17)30035-9\|pmid=28153514\|year=2017\|doi-access=free}}</ref>

	==Sources==		==Sources==

LegionMammal978: correct IUPAC name

2021-06-02T02:03:36Z

correct IUPAC name

← Previous revision		Revision as of 02:03, 2 June 2021
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	\| ImageSize = 200px		\| ImageSize = 200px
	\| ImageName = Hypoglycin		\| ImageName = Hypoglycin
	\| ~~IUPACName~~ = (''S'')-2-Amino-3-[(''R'')-2-~~methylenecyclopropyl~~]propanoic acid		\| PIN = (2''S'')-2-Amino-3-[(1''R'')-2-methylidenecyclopropyl]propanoic acid
	\| OtherNames = Hypoglycin A; Hypoglycine; 2-Methylenecyclopropanylalanine		\| OtherNames = Hypoglycin A; Hypoglycine; 2-Methylenecyclopropanylalanine
	\| Section1 = {{Chembox Identifiers		\| Section1 = {{Chembox Identifiers

Citation bot: Misc citation tidying. | You can use this bot yourself. Report bugs here. | Suggested by Lightlowemon | Category:Amino acids | via #UCB_Category 172/204

2021-01-31T13:10:05Z

Misc citation tidying. | You can use this bot yourself. Report bugs here. | Suggested by Lightlowemon | Category:Amino acids | via #UCB_Category 172/204

← Previous revision		Revision as of 13:10, 31 January 2021
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	'''Hypoglycin A''' is a naturally occurring [[amino acid]] derivative found in the unripened fruit of the [[Ackee]] tree (''[[Blighia sapida]]'')<ref name="medscape">{{cite web \| url = http://emedicine.medscape.com/article/1008792-overview \| title = Ackee Fruit Toxicity \| website = [[Medscape]]\| date = 2018-06-13 }}</ref> and in the seeds of the box elder tree (''[[Acer negundo]]'').<ref name="Valberg2013">{{Cite journal\|last1=Valberg\|first1=S. J.\|last2=Sponseller\|first2=B. T.\|last3=Hegeman\|first3=A. D.\|last4=Earing\|first4=J.\|last5=Bender\|first5=J. B.\|last6=Martinson\|first6=K. L.\|last7=Patterson\|first7=S. E.\|last8=Sweetman\|first8=L.\|date=2013-07-01\|title=Seasonal pasture myopathy/atypical myopathy in North America associated with ingestion of hypoglycin A within seeds of the box elder tree\|journal=Equine Veterinary Journal\|language=en\|volume=45\|issue=4\|pages=419–426\|doi=10.1111/j.2042-3306.2012.00684.x\|pmid=23167695\|issn=2042-3306}}</ref> It is toxic if ingested, and is the causative agent of [[Jamaican vomiting sickness]].<ref name="medscape"/> A 2017 Lancet report established a link between the consumption of unripened lychees (containing hypoglycin A or methylenecyclopropylglycine (MCPG)) resulting in hypoglycaemia and death from acute toxic encephalopathy.<ref>{{cite journal\|last1=Shrivastava\|first1=Aakash\|title=Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study\|url=http://www.thelancet.com/journals/langlo/article/PIIS2214-109X(17)30035-9/fulltext?rss=yes\|journal=The Lancet Global Health\|volume=5\|issue=4\|pages=e458–e466\|~~accessdate~~=1 February 2017\|ref=http://dx.doi.org/10.1016/S2214-109X(17)30035-9\|doi=10.1016/S2214-109X(17)30035-9\|pmid=28153514\|year=2017\|doi-access=free}}</ref>		'''Hypoglycin A''' is a naturally occurring [[amino acid]] derivative found in the unripened fruit of the [[Ackee]] tree (''[[Blighia sapida]]'')<ref name="medscape">{{cite web \| url = http://emedicine.medscape.com/article/1008792-overview \| title = Ackee Fruit Toxicity \| website = [[Medscape]]\| date = 2018-06-13 }}</ref> and in the seeds of the box elder tree (''[[Acer negundo]]'').<ref name="Valberg2013">{{Cite journal\|last1=Valberg\|first1=S. J.\|last2=Sponseller\|first2=B. T.\|last3=Hegeman\|first3=A. D.\|last4=Earing\|first4=J.\|last5=Bender\|first5=J. B.\|last6=Martinson\|first6=K. L.\|last7=Patterson\|first7=S. E.\|last8=Sweetman\|first8=L.\|date=2013-07-01\|title=Seasonal pasture myopathy/atypical myopathy in North America associated with ingestion of hypoglycin A within seeds of the box elder tree\|journal=Equine Veterinary Journal\|language=en\|volume=45\|issue=4\|pages=419–426\|doi=10.1111/j.2042-3306.2012.00684.x\|pmid=23167695\|issn=2042-3306}}</ref> It is toxic if ingested, and is the causative agent of [[Jamaican vomiting sickness]].<ref name="medscape"/> A 2017 Lancet report established a link between the consumption of unripened lychees (containing hypoglycin A or methylenecyclopropylglycine (MCPG)) resulting in hypoglycaemia and death from acute toxic encephalopathy.<ref>{{cite journal\|last1=Shrivastava\|first1=Aakash\|title=Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study\|url=http://www.thelancet.com/journals/langlo/article/PIIS2214-109X(17)30035-9/fulltext?rss=yes\|journal=The Lancet Global Health\|volume=5\|issue=4\|pages=e458–e466\|access-date=1 February 2017\|ref=http://dx.doi.org/10.1016/S2214-109X(17)30035-9\|doi=10.1016/S2214-109X(17)30035-9\|pmid=28153514\|year=2017\|doi-access=free}}</ref>

	==Sources==		==Sources==