Hypromellose - Revision history

Citation bot: Added publisher. | Use this bot. Report bugs. | Suggested by Abductive | Category:E-number additives | #UCB_Category 136/313

2024-09-11T15:58:56Z

Added publisher. | Use this bot. Report bugs. | Suggested by Abductive | Category:E-number additives | #UCB_Category 136/313

← Previous revision		Revision as of 15:58, 11 September 2024
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	\| title = Excipient Toxicity and Safety		\| title = Excipient Toxicity and Safety
	\| year = 1999		\| year = 1999
			\| publisher = Taylor & Francis
	\| url-access = registration		\| url-access = registration
	\| url = https://archive.org/details/excipienttoxicit103wein/page/8		\| url = https://archive.org/details/excipienttoxicit103wein/page/8
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	\| title = Chirality in Drug Design and Development		\| title = Chirality in Drug Design and Development
	\| year = 2004		\| year = 2004
			\| publisher = Taylor & Francis
	}}</ref><ref>{{Cite book		}}</ref><ref>{{Cite book
	\| isbn = 9780849317460		\| isbn = 9780849317460

InternetArchiveBot: Rescuing 1 sources and tagging 0 as dead.) #IABot (v2.0.9.5

2024-08-27T19:46:28Z

Rescuing 1 sources and tagging 0 as dead.) #IABot (v2.0.9.5

← Previous revision		Revision as of 19:46, 27 August 2024
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	===Ophthalmic applications===		===Ophthalmic applications===
	Hypromellose solutions were patented as a semisynthetic substitute for tear-film.<ref>[http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5,679,713.PN.&OS=PN/5,679,713&RS=PN/5,679,713 US Pat. No. 5,679,713]</ref> Its molecular structure is predicated upon a base celluloid compound that is highly water-soluble. Post-application, celluloid attributes of good water solubility reportedly aid in visual clarity. When applied, a hypromellose solution acts to swell and absorb water, thereby expanding the thickness of the tear-film. Hypromellose augmentation therefore results in extended lubricant time presence on the cornea, which theoretically results in decreased eye irritation, especially in dry climates, home, or work environments.<ref>{{cite journal \|vauthors=Koroloff N, Boots R, Lipman J, Thomas P, Rickard C, Coyer F \|title=A randomised controlled study of the efficacy of hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient \|journal=Intensive Care Med \|volume=30 \|issue=6 \|pages=1122–6 \|date=June 2004 \|pmid=15014864 \|doi=10.1007/s00134-004-2203-y\|s2cid=28523038 \|url=https://eprints.qut.edu.au/1359/1/1359.pdf }}</ref> On a molecular level, this polymer contains beta-linked D-glucose units that remain metabolically intact for days to weeks. On a manufacturing note, since hypromellose is a vegetarian substitute for gelatin, it is slightly more expensive to produce due to semisynthetic manufacturing processes. Aside from its widespread commercial and retail availability [[Over-the-counter drugs\|over the counter]] in a variety of products, hypromellose 2% solution has been documented to be used during surgery to aid in corneal protection and during orbital surgery.		Hypromellose solutions were patented as a semisynthetic substitute for tear-film.<ref>{{Cite web \|url=http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=5,679,713.PN.&OS=PN/5,679,713&RS=PN/5,679,713 \|title=US Pat. No. 5,679,713 \|access-date=2007-03-23 \|archive-date=2016-12-22 \|archive-url=https://web.archive.org/web/20161222002256/http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=/netahtml/PTO/srchnum.htm&r=1&f=G&l=50&s1=5,679,713.PN.&OS=PN/5,679,713&RS=PN/5,679,713 \|url-status=dead }}</ref> Its molecular structure is predicated upon a base celluloid compound that is highly water-soluble. Post-application, celluloid attributes of good water solubility reportedly aid in visual clarity. When applied, a hypromellose solution acts to swell and absorb water, thereby expanding the thickness of the tear-film. Hypromellose augmentation therefore results in extended lubricant time presence on the cornea, which theoretically results in decreased eye irritation, especially in dry climates, home, or work environments.<ref>{{cite journal \|vauthors=Koroloff N, Boots R, Lipman J, Thomas P, Rickard C, Coyer F \|title=A randomised controlled study of the efficacy of hypromellose and Lacri-Lube combination versus polyethylene/Cling wrap to prevent corneal epithelial breakdown in the semiconscious intensive care patient \|journal=Intensive Care Med \|volume=30 \|issue=6 \|pages=1122–6 \|date=June 2004 \|pmid=15014864 \|doi=10.1007/s00134-004-2203-y\|s2cid=28523038 \|url=https://eprints.qut.edu.au/1359/1/1359.pdf }}</ref> On a molecular level, this polymer contains beta-linked D-glucose units that remain metabolically intact for days to weeks. On a manufacturing note, since hypromellose is a vegetarian substitute for gelatin, it is slightly more expensive to produce due to semisynthetic manufacturing processes. Aside from its widespread commercial and retail availability [[Over-the-counter drugs\|over the counter]] in a variety of products, hypromellose 2% solution has been documented to be used during surgery to aid in corneal protection and during orbital surgery.

	===Excipient/tableting ingredient===		===Excipient/tableting ingredient===

Psychologist Guy: /* Excipient/tableting ingredient */ remove unsourced claim

2023-03-09T22:39:30Z

Excipient/tableting ingredient: remove unsourced claim

← Previous revision		Revision as of 22:39, 9 March 2023
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	\| title = Handbook of Pharmaceutical Manufacturing Formulations		\| title = Handbook of Pharmaceutical Manufacturing Formulations
	\| year = 2004		\| year = 2004
			}}</ref>
	}}</ref> There is a growing body of anecdotal evidence that hypromellose can cause intestinal problems in some humans, even as far as an allergic reaction.{{Citation needed\|date=October 2022}}

	==Test methods==		==Test methods==

Ancelmsmith at 13:18, 1 March 2023

2023-03-01T13:18:10Z

← Previous revision		Revision as of 13:18, 1 March 2023
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	* Eye drops		* Eye drops
	* Contact lenses		* Contact lenses
			* Polyvinyl Chloride (PVC)<ref>{{Cite web \|title=HPMC\|url=https://www.kimachemical.com/products/hydroxypropyl-methyl-cellulose-hpmc/\|access-date=1 March 2023\|website=www.kimachemical.com}}</ref>

	===Use in whole grain breads===		===Use in whole grain breads===

Vsmith: Reverted edits by Jinyushengwu (talk) to last version by InternetArchiveBot

2023-02-26T14:13:13Z

Reverted edits by Jinyushengwu (talk) to last version by InternetArchiveBot

← Previous revision		Revision as of 14:13, 26 February 2023
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	\| ImageFile = Hypromellose.png		\| ImageFile = Hypromellose.png
	\| IUPACName =		\| IUPACName =
	\| OtherNames = Hydroxypropyl methylcellulose; hydroxypropyl methyl cellulose; HPMC; E464~~:MHPC<ref>{{Cite web\|url=https://www.kimachemical.com/hydroxypropyl-methylcellulosehpmc.html\|title=Hydroxypropyl Methylcellulose\|website=kimachemical.com\|access-date=26 February 2023}}</ref>~~		\| OtherNames = Hydroxypropyl methylcellulose; hydroxypropyl methyl cellulose; HPMC; E464
	\|Section1={{Chembox Identifiers		\|Section1={{Chembox Identifiers
	\| ChemSpiderID_Ref = {{chemspidercite\|correct\|chemspider}}		\| ChemSpiderID_Ref = {{chemspidercite\|correct\|chemspider}}

Jinyushengwu at 08:24, 26 February 2023

2023-02-26T08:24:39Z

← Previous revision		Revision as of 08:24, 26 February 2023
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	\| ImageFile = Hypromellose.png		\| ImageFile = Hypromellose.png
	\| IUPACName =		\| IUPACName =
	\| OtherNames = Hydroxypropyl methylcellulose; hydroxypropyl methyl cellulose; HPMC; E464		\| OtherNames = Hydroxypropyl methylcellulose; hydroxypropyl methyl cellulose; HPMC; E464:MHPC<ref>{{Cite web\|url=https://www.kimachemical.com/hydroxypropyl-methylcellulosehpmc.html\|title=Hydroxypropyl Methylcellulose\|website=kimachemical.com\|access-date=26 February 2023}}</ref>
	\|Section1={{Chembox Identifiers		\|Section1={{Chembox Identifiers
	\| ChemSpiderID_Ref = {{chemspidercite\|correct\|chemspider}}		\| ChemSpiderID_Ref = {{chemspidercite\|correct\|chemspider}}

InternetArchiveBot: Rescuing 1 sources and tagging 0 as dead.) #IABot (v2.0.9.3

2023-01-13T18:02:39Z

Rescuing 1 sources and tagging 0 as dead.) #IABot (v2.0.9.3

← Previous revision		Revision as of 18:02, 13 January 2023
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	== Uses ==		== Uses ==
	There are many fields of application for hypromellose, including:<ref>[http://www.ginshicel.cn/MHPC.html Example properties and applications of hydroxypropyl methyl cellulose]</ref>		There are many fields of application for hypromellose, including:<ref>{{Cite web \|url=http://www.ginshicel.cn/MHPC.html \|title=Example properties and applications of hydroxypropyl methyl cellulose \|access-date=2008-10-16 \|archive-date=2010-05-04 \|archive-url=https://web.archive.org/web/20100504113623/http://www.ginshicel.cn/MHPC.html \|url-status=dead }}</ref>

	* Tile adhesives		* Tile adhesives

SimLibrarian: /* Uses */ rm ampersands

2022-11-11T21:29:12Z

Uses: rm ampersands

← Previous revision		Revision as of 21:29, 11 November 2022
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	* Gypsum products		* Gypsum products
	* Pharmaceutical		* Pharmaceutical
	* Paints & coatings		* Paints and coatings
	* Food		* Food
	* Cosmetics		* Cosmetics
	* Detergents & cleaners		* Detergents and cleaners
	* Eye drops		* Eye drops
	* Contact lenses		* Contact lenses
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	===Use in construction materials===		===Use in construction materials===
	HPMC is used primarily in construction materials like tile adhesives and renders<ref>[http://www.dow.com/methocel/ ] {{webarchive \|url=https://web.archive.org/web/20081231215558/http://www.dow.com/methocel/ \|date=December 31, 2008 }}</ref> where it is used as a [[rheology]] modifier and water retention agent.		HPMC is used primarily in construction materials like tile adhesives and renders<ref>[http://www.dow.com/methocel/] {{webarchive\|url=https://web.archive.org/web/20081231215558/http://www.dow.com/methocel/\|date=December 31, 2008}}</ref> where it is used as a [[rheology]] modifier and water retention agent.

	Functionally HPMC is very similar to HEMC (hydroxy ethyl methyl cellulose) Trade names include Methocel and Walocel. The global leading producer is now DuPont, formerly manufactured under Dow Wolff Cellulosics GmbH.<ref>{{cite web\|url=http://www.dow.com/dowwolff/en/about/ \|title=About Us \|publisher=Dow.com \|access-date=2013-01-01 \|url-status=dead \|archive-url=https://web.archive.org/web/20130104225922/http://www.dow.com/dowwolff/en/about/ \|archive-date=2013-01-04 }}</ref>		Functionally HPMC is very similar to HEMC (hydroxy ethyl methyl cellulose) Trade names include Methocel and Walocel. The global leading producer is now DuPont, formerly manufactured under Dow Wolff Cellulosics GmbH.<ref>{{cite web\|url=http://www.dow.com/dowwolff/en/about/ \|title=About Us \|publisher=Dow.com \|access-date=2013-01-01 \|url-status=dead \|archive-url=https://web.archive.org/web/20130104225922/http://www.dow.com/dowwolff/en/about/ \|archive-date=2013-01-04 }}</ref>

2A00:A040:195:D4F0:F40C:91D6:4740:847C: /* Excipient/tableting ingredient */

2022-10-06T05:49:58Z

Excipient/tableting ingredient

← Previous revision		Revision as of 05:49, 6 October 2022
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	\| title = Handbook of Pharmaceutical Manufacturing Formulations		\| title = Handbook of Pharmaceutical Manufacturing Formulations
	\| year = 2004		\| year = 2004
	}}</ref> There is a growing body of anecdotal evidence that hypromellose can cause intestinal problems in some humans, even as far as an allergic reaction.		}}</ref> There is a growing body of anecdotal evidence that hypromellose can cause intestinal problems in some humans, even as far as an allergic reaction.{{Citation needed\|date=October 2022}}

	==Test methods==		==Test methods==

AndyFielding: Maybe I'm wrong, but it seems unlikely that the compound is the drops' only ingredient, as the text implied.

2022-09-03T09:10:03Z

Maybe I'm wrong, but it seems unlikely that the compound is the drops' only ingredient, as the text implied.

← Previous revision		Revision as of 09:10, 3 September 2022
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	}}		}}

	'''Hypromellose''' ([[International Nonproprietary Name\|INN]]), short for '''hydroxypropyl methylcellulose''' ('''HPMC'''), is a [[semisynthesis\|semisynthetic]], inert, viscoelastic [[polymer]] used as eye drops, as well as an [[excipient]] and controlled-delivery component in oral medicaments, found in a variety of commercial products.<ref>{{cite journal \|vauthors=de Silva DJ, Olver JM \|title=Hydroxypropyl methylcellulose (HPMC) lubricant facilitates insertion of porous spherical orbital implants \|journal=Ophthal Plast Reconstr Surg \|volume=21 \|issue=4 \|pages=301–2 \|date=July 2005 \|pmid=16052145 \|doi=10.1097/01.iop.0000170417.19223.6c}}</ref><ref>{{cite journal \|vauthors=Williams RO, Sykora MA, Mahaguna V \|title=Method to recover a lipophilic drug from hydroxypropyl methylcellulose matrix tablets \|journal=AAPS PharmSciTech \|volume=2 \|issue=2 \|pages=29–37 \|year=2001 \|pmid=14727883 \|doi=10.1208/pt020208 \|pmc=2750474}}</ref>		'''Hypromellose''' ([[International Nonproprietary Name\|INN]]), short for '''hydroxypropyl methylcellulose''' ('''HPMC'''), is a [[semisynthesis\|semisynthetic]], inert, viscoelastic [[polymer]] used in eye drops, as well as an [[excipient]] and controlled-delivery component in oral medicaments, found in a variety of commercial products.<ref>{{cite journal \|vauthors=de Silva DJ, Olver JM \|title=Hydroxypropyl methylcellulose (HPMC) lubricant facilitates insertion of porous spherical orbital implants \|journal=Ophthal Plast Reconstr Surg \|volume=21 \|issue=4 \|pages=301–2 \|date=July 2005 \|pmid=16052145 \|doi=10.1097/01.iop.0000170417.19223.6c}}</ref><ref>{{cite journal \|vauthors=Williams RO, Sykora MA, Mahaguna V \|title=Method to recover a lipophilic drug from hydroxypropyl methylcellulose matrix tablets \|journal=AAPS PharmSciTech \|volume=2 \|issue=2 \|pages=29–37 \|year=2001 \|pmid=14727883 \|doi=10.1208/pt020208 \|pmc=2750474}}</ref>

	As a [[food additive]], hypromellose is an [[emulsifier]], [[Thickening agent\|thickening]] and suspending agent, and an alternative to [[Gelatin\|animal gelatin]].<ref>[http://www.ams.usda.gov/nop/NationalList/TAPReviews/HPMethylcellulose.pdf NOSB TAP Review Compiled by OMRI: Hydroxypropyl Methylcellulose]</ref> Its [[Codex Alimentarius]] code ([[E number]]) is E464.		As a [[food additive]], hypromellose is an [[emulsifier]], [[Thickening agent\|thickening]] and suspending agent, and an alternative to [[Gelatin\|animal gelatin]].<ref>[http://www.ams.usda.gov/nop/NationalList/TAPReviews/HPMethylcellulose.pdf NOSB TAP Review Compiled by OMRI: Hydroxypropyl Methylcellulose]</ref> Its [[Codex Alimentarius]] code ([[E number]]) is E464.