ICP8 - Revision history

RScheiber: /* External links */ refined category

2020-12-26T00:08:00Z

External links: refined category

← Previous revision		Revision as of 00:08, 26 December 2020
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	[[Category:Simplexviruses]]		[[Category:Simplexviruses]]
	[[Category:Viral proteins]]		[[Category:Viral nonstructural proteins]]

RScheiber: WL

2020-12-25T23:53:30Z

← Previous revision		Revision as of 23:53, 25 December 2020
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	'''ICP8''', the '''herpes simplex virus type-1 single-strand DNA-binding protein''', is one of seven [[protein]]s encoded in the [[virus\|viral]] [[genome]] of [[Herpes simplex virus\|HSV-1]] that is required for HSV-1 [[DNA replication]].<ref name="Pmid">{{cite journal\|pmid=8380461\|year=1993\|last1=Boehmer\|first1=PE\|last2=Lehman\|first2=IR\|title=Herpes simplex virus type 1 ICP8: Helix-destabilizing properties\|volume=67\|issue=2\|pages=711–5\|pmc=237422\|journal=Journal of Virology}}</ref> It is able to anneal to single-stranded DNA (ssDNA) as well as [[Nucleic acid thermodynamics#Denaturation\|melt]] small fragments of double-stranded DNA (dsDNA);<ref name="Pmid" /> its role is to destabilize duplex DNA during initiation of replication. It differs from [[helicase]]s because it is [[Adenosine triphosphate\|ATP]]- and [[Magnesium\|Mg]]<sup>2+</sup>-independent.<ref name="Pmid" /> In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8.		'''ICP8''', the '''herpes simplex virus type-1 single-strand DNA-binding protein''', is one of seven [[protein]]s encoded in the [[virus\|viral]] [[genome]] of [[Herpes simplex virus\|HSV-1]] that is required for HSV-1 [[DNA replication]].<ref name="Pmid">{{cite journal\|pmid=8380461\|year=1993\|last1=Boehmer\|first1=PE\|last2=Lehman\|first2=IR\|title=Herpes simplex virus type 1 ICP8: Helix-destabilizing properties\|volume=67\|issue=2\|pages=711–5\|pmc=237422\|journal=Journal of Virology}}</ref> It is able to anneal to single-stranded DNA ([[ssDNA]]) as well as [[Nucleic acid thermodynamics#Denaturation\|melt]] small fragments of double-stranded DNA (dsDNA);<ref name="Pmid" /> its role is to destabilize duplex DNA during initiation of replication. It differs from [[helicase]]s because it is [[Adenosine triphosphate\|ATP]]- and [[Magnesium\|Mg]]<sup>2+</sup>-independent.<ref name="Pmid" /> In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8.

	ICP8 is required in late gene [[Transcription (genetics)\|transcription]], and has found to be associated with cellular [[RNA polymerase II holoenzyme]].<ref>{{cite journal\|pmid=12021322\|year=2002\|last1=Zhou\|first1=C\|last2=Knipe\|first2=DM\|title=Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme\|volume=76\|issue=12\|pages=5893–904\|pmc=136207\|journal=Journal of Virology\|doi=10.1128/JVI.76.12.5893-5904.2002		ICP8 is required in late gene [[Transcription (genetics)\|transcription]], and has found to be associated with cellular [[RNA polymerase II holoenzyme]].<ref>{{cite journal\|pmid=12021322\|year=2002\|last1=Zhou\|first1=C\|last2=Knipe\|first2=DM\|title=Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme\|volume=76\|issue=12\|pages=5893–904\|pmc=136207\|journal=Journal of Virology\|doi=10.1128/JVI.76.12.5893-5904.2002

RScheiber: added long name

2020-07-16T13:09:21Z

added long name

← Previous revision		Revision as of 13:09, 16 July 2020
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	'''ICP8''', the '''herpes simplex virus type-1 single-strand DNA-binding protein''', is one of seven [[protein]]s encoded in the [[virus\|viral]] [[genome]] of [[Herpes simplex virus\|HSV-1]] that is required for HSV-1 [[DNA replication]].<ref name="Pmid">{{cite journal\|pmid=8380461\|year=1993\|last1=Boehmer\|first1=PE\|last2=Lehman\|first2=IR\|title=Herpes simplex virus type 1 ICP8: Helix-destabilizing properties\|volume=67\|issue=2\|pages=711–5\|pmc=237422\|journal=Journal of Virology}}</ref> It is able to anneal to single-stranded DNA (ssDNA) as well as [[Nucleic acid thermodynamics#Denaturation\|melt]] small fragments of dsDNA;<ref name="Pmid" /> its role is to destabilize duplex DNA during initiation of replication. It differs from [[helicase]]s because it is [[Adenosine triphosphate\|ATP]]- and [[Magnesium\|Mg]]<sup>2+</sup>-independent.<ref name="Pmid" /> In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8.		'''ICP8''', the '''herpes simplex virus type-1 single-strand DNA-binding protein''', is one of seven [[protein]]s encoded in the [[virus\|viral]] [[genome]] of [[Herpes simplex virus\|HSV-1]] that is required for HSV-1 [[DNA replication]].<ref name="Pmid">{{cite journal\|pmid=8380461\|year=1993\|last1=Boehmer\|first1=PE\|last2=Lehman\|first2=IR\|title=Herpes simplex virus type 1 ICP8: Helix-destabilizing properties\|volume=67\|issue=2\|pages=711–5\|pmc=237422\|journal=Journal of Virology}}</ref> It is able to anneal to single-stranded DNA (ssDNA) as well as [[Nucleic acid thermodynamics#Denaturation\|melt]] small fragments of double-stranded DNA (dsDNA);<ref name="Pmid" /> its role is to destabilize duplex DNA during initiation of replication. It differs from [[helicase]]s because it is [[Adenosine triphosphate\|ATP]]- and [[Magnesium\|Mg]]<sup>2+</sup>-independent.<ref name="Pmid" /> In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8.

	ICP8 is required in late gene [[Transcription (genetics)\|transcription]], and has found to be associated with cellular [[RNA polymerase II holoenzyme]].<ref>{{cite journal\|pmid=12021322\|year=2002\|last1=Zhou\|first1=C\|last2=Knipe\|first2=DM\|title=Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme\|volume=76\|issue=12\|pages=5893–904\|pmc=136207\|journal=Journal of Virology\|doi=10.1128/JVI.76.12.5893-5904.2002		ICP8 is required in late gene [[Transcription (genetics)\|transcription]], and has found to be associated with cellular [[RNA polymerase II holoenzyme]].<ref>{{cite journal\|pmid=12021322\|year=2002\|last1=Zhou\|first1=C\|last2=Knipe\|first2=DM\|title=Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme\|volume=76\|issue=12\|pages=5893–904\|pmc=136207\|journal=Journal of Virology\|doi=10.1128/JVI.76.12.5893-5904.2002

RScheiber: /* External links */ added Template:Viral proteins

2020-07-16T13:07:50Z

External links: added Template:Viral proteins

← Previous revision		Revision as of 13:07, 16 July 2020
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	==External links==		==External links==
	*[https://www.uniprot.org/uniprot/P04296 ICP8 on UniProt]		*[https://www.uniprot.org/uniprot/P04296 ICP8 on UniProt]
			{{Viral proteins}}

	[[Category:Simplexviruses]]		[[Category:Simplexviruses]]

KolbertBot: Bot: HTTP→HTTPS (v485)

2018-03-23T08:51:49Z

Bot: HTTP→HTTPS (v485)

← Previous revision		Revision as of 08:51, 23 March 2018
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	==External links==		==External links==
	*[~~http~~://www.uniprot.org/uniprot/P04296 ICP8 on UniProt]		*[https://www.uniprot.org/uniprot/P04296 ICP8 on UniProt]

	[[Category:Simplexviruses]]		[[Category:Simplexviruses]]

Rjwilmsi: /* top */Journal cites, format journal names, using AWB (11837)

2016-01-27T15:27:00Z

top: Journal cites, format journal names, using AWB (11837)

← Previous revision		Revision as of 15:27, 27 January 2016
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	'''ICP8''', the '''herpes simplex virus type-1 single-strand DNA-binding protein''', is one of seven [[protein]]s encoded in the [[virus\|viral]] [[genome]] of [[Herpes simplex virus\|HSV-1]] that is required for HSV-1 [[DNA replication]].<ref name="Pmid">{{cite journal\|pmid=8380461\|year=1993\|last1=Boehmer\|first1=PE\|last2=Lehman\|first2=IR\|title=Herpes simplex virus type 1 ICP8: Helix-destabilizing properties\|volume=67\|issue=2\|pages=711–5\|pmc=237422\|journal=Journal of ~~virology~~}}</ref> It is able to anneal to single-stranded DNA (ssDNA) as well as [[Nucleic acid thermodynamics#Denaturation\|melt]] small fragments of dsDNA;<ref name="Pmid" /> its role is to destabilize duplex DNA during initiation of replication. It differs from [[helicase]]s because it is [[Adenosine triphosphate\|ATP]]- and [[Magnesium\|Mg]]<sup>2+</sup>-independent.<ref name="Pmid" /> In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8.		'''ICP8''', the '''herpes simplex virus type-1 single-strand DNA-binding protein''', is one of seven [[protein]]s encoded in the [[virus\|viral]] [[genome]] of [[Herpes simplex virus\|HSV-1]] that is required for HSV-1 [[DNA replication]].<ref name="Pmid">{{cite journal\|pmid=8380461\|year=1993\|last1=Boehmer\|first1=PE\|last2=Lehman\|first2=IR\|title=Herpes simplex virus type 1 ICP8: Helix-destabilizing properties\|volume=67\|issue=2\|pages=711–5\|pmc=237422\|journal=Journal of Virology}}</ref> It is able to anneal to single-stranded DNA (ssDNA) as well as [[Nucleic acid thermodynamics#Denaturation\|melt]] small fragments of dsDNA;<ref name="Pmid" /> its role is to destabilize duplex DNA during initiation of replication. It differs from [[helicase]]s because it is [[Adenosine triphosphate\|ATP]]- and [[Magnesium\|Mg]]<sup>2+</sup>-independent.<ref name="Pmid" /> In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8.

	ICP8 is required in late gene [[Transcription (genetics)\|transcription]], and has found to be associated with cellular [[RNA polymerase II holoenzyme]].<ref>{{cite journal\|pmid=12021322\|year=2002\|last1=Zhou\|first1=C\|last2=Knipe\|first2=DM\|title=Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme\|volume=76\|issue=12\|pages=5893–904\|pmc=136207\|journal=Journal of ~~virology~~\|doi=10.1128/JVI.76.12.5893-5904.2002		ICP8 is required in late gene [[Transcription (genetics)\|transcription]], and has found to be associated with cellular [[RNA polymerase II holoenzyme]].<ref>{{cite journal\|pmid=12021322\|year=2002\|last1=Zhou\|first1=C\|last2=Knipe\|first2=DM\|title=Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme\|volume=76\|issue=12\|pages=5893–904\|pmc=136207\|journal=Journal of Virology\|doi=10.1128/JVI.76.12.5893-5904.2002
	}}</ref>		}}</ref>

Ruslik0: added Category:Viral proteins using HotCat

2013-06-22T15:01:32Z

added Category:Viral proteins using HotCat

← Previous revision		Revision as of 15:01, 22 June 2013
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	[[Category:Simplexviruses]]		[[Category:Simplexviruses]]
			[[Category:Viral proteins]]

Ruslik0: removed Category:Virology; added Category:Simplexviruses using HotCat

2013-06-22T15:01:21Z

removed Category:Virology; added Category:Simplexviruses using HotCat

← Previous revision		Revision as of 15:01, 22 June 2013
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	*[http://www.uniprot.org/uniprot/P04296 ICP8 on UniProt]		*[http://www.uniprot.org/uniprot/P04296 ICP8 on UniProt]

	[[Category:~~Virology~~]]		[[Category:Simplexviruses]]

Kinkreet: Fixed disamb links

2013-03-09T15:04:02Z

Fixed disamb links

← Previous revision		Revision as of 15:04, 9 March 2013
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	'''ICP8''', the '''herpes simplex virus type-1 single-strand DNA-binding protein''', is one of seven [[protein]]s encoded in the [[~~viral\|~~virus]] [[genome]] of [[Herpes simplex virus\|HSV-1]] that is required for HSV-1 [[DNA replication]].<ref name="Pmid">{{cite journal\|pmid=8380461\|year=1993\|last1=Boehmer\|first1=PE\|last2=Lehman\|first2=IR\|title=Herpes simplex virus type 1 ICP8: Helix-destabilizing properties\|volume=67\|issue=2\|pages=711–5\|pmc=237422\|journal=Journal of virology}}</ref> It is able to anneal to single-stranded DNA (ssDNA) as well as [[Nucleic acid thermodynamics#Denaturation\|melt]] small fragments of dsDNA;<ref name="Pmid" /> its role is to destabilize duplex DNA during initiation of replication. It differs from [[helicase]s because it is [[ATP]]- and [[Magnesium\|Mg]]<sup>2+</sup>-independent.<ref name="Pmid" /> In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8.		'''ICP8''', the '''herpes simplex virus type-1 single-strand DNA-binding protein''', is one of seven [[protein]]s encoded in the [[virus\|viral]] [[genome]] of [[Herpes simplex virus\|HSV-1]] that is required for HSV-1 [[DNA replication]].<ref name="Pmid">{{cite journal\|pmid=8380461\|year=1993\|last1=Boehmer\|first1=PE\|last2=Lehman\|first2=IR\|title=Herpes simplex virus type 1 ICP8: Helix-destabilizing properties\|volume=67\|issue=2\|pages=711–5\|pmc=237422\|journal=Journal of virology}}</ref> It is able to anneal to single-stranded DNA (ssDNA) as well as [[Nucleic acid thermodynamics#Denaturation\|melt]] small fragments of dsDNA;<ref name="Pmid" /> its role is to destabilize duplex DNA during initiation of replication. It differs from [[helicase]]s because it is [[Adenosine triphosphate\|ATP]]- and [[Magnesium\|Mg]]<sup>2+</sup>-independent.<ref name="Pmid" /> In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8.

	ICP8 is required in late gene [[transcription]], and has found to be associated with cellular [[RNA polymerase II holoenzyme]].<ref>{{cite journal\|pmid=12021322\|year=2002\|last1=Zhou\|first1=C\|last2=Knipe\|first2=DM\|title=Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme\|volume=76\|issue=12\|pages=5893–904\|pmc=136207\|journal=Journal of virology\|doi=10.1128/JVI.76.12.5893-5904.2002		ICP8 is required in late gene [[Transcription (genetics)\|transcription]], and has found to be associated with cellular [[RNA polymerase II holoenzyme]].<ref>{{cite journal\|pmid=12021322\|year=2002\|last1=Zhou\|first1=C\|last2=Knipe\|first2=DM\|title=Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme\|volume=76\|issue=12\|pages=5893–904\|pmc=136207\|journal=Journal of virology\|doi=10.1128/JVI.76.12.5893-5904.2002
	}}</ref>		}}</ref>

Citation bot: [419]Add: year, last1, first1, last2, first2, title, volume, issue, pages, pmc, journal, doi. Tweak: year, last1, first1, last2, first2, title, volume, issue, pages, pmc. Formatted dashes. | Kinkreet

2013-03-08T13:43:44Z

[419]Add: year, last1, first1, last2, first2, title, volume, issue, pages, pmc, journal, doi. Tweak: year, last1, first1, last2, first2, title, volume, issue, pages, pmc. Formatted dashes. | Kinkreet

← Previous revision		Revision as of 13:43, 8 March 2013
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	'''ICP8''', the '''herpes simplex virus type-1 single-strand DNA-binding protein''', is one of seven [[protein]]s encoded in the [[viral\|virus]] [[genome]] of [[Herpes simplex virus\|HSV-1]] that is required for HSV-1 [[DNA replication]].<ref name="Pmid">{{cite journal\|pmid=8380461\|year=1993\|last1=Boehmer\|first1=PE\|last2=Lehman\|first2=IR\|title=Herpes simplex virus type 1 ICP8: Helix-destabilizing properties\|volume=67\|issue=2\|pages=711–5\|pmc=237422\|journal=Journal of virology}}</ref> It is able to anneal to single-stranded DNA (ssDNA) as well as [[Nucleic acid thermodynamics#Denaturation\|melt]] small fragments of dsDNA;<ref name="Pmid" /> its role is to destabilize duplex DNA during initiation of replication. It differs from [[helicase]s because it is [[ATP]]- and [[Magnesium\|Mg]]<sup>2+</sup>-independent.<ref name="Pmid" /> In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8.		'''ICP8''', the '''herpes simplex virus type-1 single-strand DNA-binding protein''', is one of seven [[protein]]s encoded in the [[viral\|virus]] [[genome]] of [[Herpes simplex virus\|HSV-1]] that is required for HSV-1 [[DNA replication]].<ref name="Pmid">{{cite journal\|pmid=8380461\|year=1993\|last1=Boehmer\|first1=PE\|last2=Lehman\|first2=IR\|title=Herpes simplex virus type 1 ICP8: Helix-destabilizing properties\|volume=67\|issue=2\|pages=711–5\|pmc=237422\|journal=Journal of virology}}</ref> It is able to anneal to single-stranded DNA (ssDNA) as well as [[Nucleic acid thermodynamics#Denaturation\|melt]] small fragments of dsDNA;<ref name="Pmid" /> its role is to destabilize duplex DNA during initiation of replication. It differs from [[helicase]s because it is [[ATP]]- and [[Magnesium\|Mg]]<sup>2+</sup>-independent.<ref name="Pmid" /> In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8.

	ICP8 is required in late gene [[transcription]], and has found to be associated with cellular [[RNA polymerase II holoenzyme]].<ref>{{cite journal\|pmid=12021322		ICP8 is required in late gene [[transcription]], and has found to be associated with cellular [[RNA polymerase II holoenzyme]].<ref>{{cite journal\|pmid=12021322\|year=2002\|last1=Zhou\|first1=C\|last2=Knipe\|first2=DM\|title=Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme\|volume=76\|issue=12\|pages=5893–904\|pmc=136207\|journal=Journal of virology\|doi=10.1128/JVI.76.12.5893-5904.2002
	}}</ref>		}}</ref>