https://en.wikipedia.org/w/index.php?action=history&feed=atom&title=In_silico
In silico - Revision history
2024-11-14T14:00:07Z
Revision history for this page on the wiki
MediaWiki 1.44.0-wmf.2
https://en.wikipedia.org/w/index.php?title=In_silico&diff=1253242687&oldid=prev
Monkbot: Task 20: replace {lang-??} templates with {langx|??} ‹See Tfd› (Replaced 1);
2024-10-25T01:04:07Z
<p><a href="/wiki/User:Monkbot/task_20" class="mw-redirect" title="User:Monkbot/task 20">Task 20</a>: replace {lang-??} templates with {langx|??} <a href="/wiki/Wikipedia:Templates_for_discussion/Log/2024_September_27#Replace_and_delete_lang-??_templates" title="Wikipedia:Templates for discussion/Log/2024 September 27">‹See Tfd›</a> (Replaced 1);</p>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Forest of synthetic pyramidal dendrites grown using Cajal's laws of neuronal branching.png|thumb|A forest of synthetic [[pyramidal cell|pyramidal]] [[dendrite]]s generated ''in silico'' using [[Santiago Ramón y Cajal|Cajal]]'s laws of neuronal branching]]</div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td>
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<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>In [[biology]] and other experimental sciences, an '''''in silico''''' experiment is one performed on a computer or via [[computer simulation]] software. The phrase is [[pseudo-Latin]] for 'in silicon' (correct {{<del style="font-weight: bold; text-decoration: none;">lang-</del>la|in silicio}}), referring to [[silicon]] in computer chips. It was coined in 1987 as an allusion to the [[Latin phrase]]s {{lang|la|[[in vivo]]}}, {{lang|la|[[in vitro]]}}, and {{lang|la|[[in situ]]}}, which are commonly used in [[biology]] (especially [[systems biology]]). The latter phrases refer, respectively, to experiments done in living organisms, outside living organisms, and where they are found in nature.</div></td>
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<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>In [[biology]] and other experimental sciences, an '''''in silico''''' experiment is one performed on a computer or via [[computer simulation]] software. The phrase is [[pseudo-Latin]] for 'in silicon' (correct {{<ins style="font-weight: bold; text-decoration: none;">langx|</ins>la|in silicio}}), referring to [[silicon]] in computer chips. It was coined in 1987 as an allusion to the [[Latin phrase]]s {{lang|la|[[in vivo]]}}, {{lang|la|[[in vitro]]}}, and {{lang|la|[[in situ]]}}, which are commonly used in [[biology]] (especially [[systems biology]]). The latter phrases refer, respectively, to experiments done in living organisms, outside living organisms, and where they are found in nature.</div></td>
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Monkbot
https://en.wikipedia.org/w/index.php?title=In_silico&diff=1233910897&oldid=prev
Gianaccordi: Add Exscalate4Cov
2024-07-11T15:19:18Z
<p>Add Exscalate4Cov</p>
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Gianaccordi
https://en.wikipedia.org/w/index.php?title=In_silico&diff=1222936058&oldid=prev
Kku: link artificial life
2024-05-08T21:13:54Z
<p>link artificial life</p>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==History==</div></td>
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<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>The earliest known use of the phrase was by [[Christopher Langton]] to describe artificial life, in the announcement of a workshop on that subject at the Center for Nonlinear Studies at the [[Los Alamos National Laboratory]] in 1987.<ref>{{Cite web|url=https://groups.google.com/forum/#!topic/news.announce.conferences/d2oq9H2venM|title=Google Groups|website=groups.google.com|access-date=2020-01-05}}</ref><ref>{{Cite book|url=https://books.google.com/books?id=-uC54_DD0tMC&pg=PA273|title=Ultimate Computing: Biomolecular Consciousness and NanoTechnology|last=Hameroff|first=S. R.|date=2014-04-11|publisher=Elsevier|isbn=978-0-444-60009-7|language=en}}</ref> The expression ''in silico'' was first used to characterize biological experiments carried out entirely in a computer in 1989, in the workshop "Cellular Automata: Theory and Applications" in Los Alamos, New Mexico, by Pedro Miramontes, a mathematician from [[National Autonomous University of Mexico]] (UNAM), presenting the report "[[DNA]] and [[RNA]] Physicochemical Constraints, Cellular Automata and Molecular Evolution". The work was later presented by Miramontes as his [[dissertation]].<ref name=Miramontes>Miramontes P. (1992) ''Un modelo de autómata celular para la evolución de los ácidos nucleicos'' [A cellular automaton model for the evolution of nucleic acids]. PhD Thesis. UNAM.</ref></div></td>
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<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>The earliest known use of the phrase was by [[Christopher Langton]] to describe <ins style="font-weight: bold; text-decoration: none;">[[</ins>artificial life<ins style="font-weight: bold; text-decoration: none;">]]</ins>, in the announcement of a workshop on that subject at the Center for Nonlinear Studies at the [[Los Alamos National Laboratory]] in 1987.<ref>{{Cite web|url=https://groups.google.com/forum/#!topic/news.announce.conferences/d2oq9H2venM|title=Google Groups|website=groups.google.com|access-date=2020-01-05}}</ref><ref>{{Cite book|url=https://books.google.com/books?id=-uC54_DD0tMC&pg=PA273|title=Ultimate Computing: Biomolecular Consciousness and NanoTechnology|last=Hameroff|first=S. R.|date=2014-04-11|publisher=Elsevier|isbn=978-0-444-60009-7|language=en}}</ref> The expression ''in silico'' was first used to characterize biological experiments carried out entirely in a computer in 1989, in the workshop "Cellular Automata: Theory and Applications" in Los Alamos, New Mexico, by Pedro Miramontes, a mathematician from [[National Autonomous University of Mexico]] (UNAM), presenting the report "[[DNA]] and [[RNA]] Physicochemical Constraints, Cellular Automata and Molecular Evolution". The work was later presented by Miramontes as his [[dissertation]].<ref name=Miramontes>Miramontes P. (1992) ''Un modelo de autómata celular para la evolución de los ácidos nucleicos'' [A cellular automaton model for the evolution of nucleic acids]. PhD Thesis. UNAM.</ref></div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>''In silico'' has been used in [[white paper]]s written to support the creation of bacterial genome programs by the Commission of the European Community. The first referenced paper where ''in silico'' appears was written by a French team in 1991.<ref name=Danchin>{{Citation| last1 = Danchin | first1 = A | last2 = Médigue | first2 = C | last3 = Gascuel | first3 = O | last4 = Soldano | first4 = H | last5 = Hénaut | first5 = A | title = From data banks to data bases | journal = Research in Microbiology | volume = 142 | issue = 7–8 | pages = 913–6 | year = 1991 | pmid = 1784830 | doi = 10.1016/0923-2508(91)90073-J | citeseerx = 10.1.1.637.3244 }}</ref> The first referenced book chapter where ''in silico'' appears was written by Hans B. Sieburg in 1990 and presented during a Summer School on Complex Systems at the Santa Fe Institute.<ref name=Sieburg>{{Citation| last1 = Sieburg | first1 = H.B. | year = 1990 | title = Physiological Studies ''in silico'' | journal = Studies in the Sciences of Complexity | volume = 12 | pages = 321–342 }}</ref></div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>''In silico'' has been used in [[white paper]]s written to support the creation of bacterial genome programs by the Commission of the European Community. The first referenced paper where ''in silico'' appears was written by a French team in 1991.<ref name=Danchin>{{Citation| last1 = Danchin | first1 = A | last2 = Médigue | first2 = C | last3 = Gascuel | first3 = O | last4 = Soldano | first4 = H | last5 = Hénaut | first5 = A | title = From data banks to data bases | journal = Research in Microbiology | volume = 142 | issue = 7–8 | pages = 913–6 | year = 1991 | pmid = 1784830 | doi = 10.1016/0923-2508(91)90073-J | citeseerx = 10.1.1.637.3244 }}</ref> The first referenced book chapter where ''in silico'' appears was written by Hans B. Sieburg in 1990 and presented during a Summer School on Complex Systems at the Santa Fe Institute.<ref name=Sieburg>{{Citation| last1 = Sieburg | first1 = H.B. | year = 1990 | title = Physiological Studies ''in silico'' | journal = Studies in the Sciences of Complexity | volume = 12 | pages = 321–342 }}</ref></div></td>
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Kku
https://en.wikipedia.org/w/index.php?title=In_silico&diff=1195334023&oldid=prev
CrafterNova: +using software
2024-01-13T12:21:38Z
<p>+using software</p>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td>
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<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>In [[biology]] and other experimental sciences, an '''''in silico''''' experiment is one performed on a computer or via [[computer simulation]]<del style="font-weight: bold; text-decoration: none;">.</del> The phrase is [[pseudo-Latin]] for 'in silicon' (correct {{lang-la|in silicio}}), referring to [[silicon]] in computer chips. It was coined in 1987 as an allusion to the [[Latin phrase]]s {{lang|la|[[in vivo]]}}, {{lang|la|[[in vitro]]}}, and {{lang|la|[[in situ]]}}, which are commonly used in [[biology]] (especially [[systems biology]]). The latter phrases refer, respectively, to experiments done in living organisms, outside living organisms, and where they are found in nature.</div></td>
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<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>In [[biology]] and other experimental sciences, an '''''in silico''''' experiment is one performed on a computer or via [[computer simulation]] <ins style="font-weight: bold; text-decoration: none;">software.</ins> The phrase is [[pseudo-Latin]] for 'in silicon' (correct {{lang-la|in silicio}}), referring to [[silicon]] in computer chips. It was coined in 1987 as an allusion to the [[Latin phrase]]s {{lang|la|[[in vivo]]}}, {{lang|la|[[in vitro]]}}, and {{lang|la|[[in situ]]}}, which are commonly used in [[biology]] (especially [[systems biology]]). The latter phrases refer, respectively, to experiments done in living organisms, outside living organisms, and where they are found in nature.</div></td>
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CrafterNova
https://en.wikipedia.org/w/index.php?title=In_silico&diff=1195333922&oldid=prev
CrafterNova: wording fix
2024-01-13T12:20:43Z
<p>wording fix</p>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Forest of synthetic pyramidal dendrites grown using Cajal's laws of neuronal branching.png|thumb|A forest of synthetic [[pyramidal cell|pyramidal]] [[dendrite]]s generated ''in silico'' using [[Santiago Ramón y Cajal|Cajal]]'s laws of neuronal branching]]</div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Forest of synthetic pyramidal dendrites grown using Cajal's laws of neuronal branching.png|thumb|A forest of synthetic [[pyramidal cell|pyramidal]] [[dendrite]]s generated ''in silico'' using [[Santiago Ramón y Cajal|Cajal]]'s laws of neuronal branching]]</div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td>
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<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>In [[biology]] and other experimental sciences, an '''''in silico''''' experiment is one performed on computer or via [[computer simulation]]. The phrase is [[pseudo-Latin]] for 'in silicon' (correct {{lang-la|in silicio}}), referring to [[silicon]] in computer chips. It was coined in 1987 as an allusion to the [[Latin phrase]]s {{lang|la|[[in vivo]]}}, {{lang|la|[[in vitro]]}}, and {{lang|la|[[in situ]]}}, which are commonly used in [[biology]] (especially [[systems biology]]). The latter phrases refer, respectively, to experiments done in living organisms, outside living organisms, and where they are found in nature.</div></td>
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<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>In [[biology]] and other experimental sciences, an '''''in silico''''' experiment is one performed on<ins style="font-weight: bold; text-decoration: none;"> a</ins> computer or via [[computer simulation]]. The phrase is [[pseudo-Latin]] for 'in silicon' (correct {{lang-la|in silicio}}), referring to [[silicon]] in computer chips. It was coined in 1987 as an allusion to the [[Latin phrase]]s {{lang|la|[[in vivo]]}}, {{lang|la|[[in vitro]]}}, and {{lang|la|[[in situ]]}}, which are commonly used in [[biology]] (especially [[systems biology]]). The latter phrases refer, respectively, to experiments done in living organisms, outside living organisms, and where they are found in nature.</div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==History==</div></td>
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CrafterNova
https://en.wikipedia.org/w/index.php?title=In_silico&diff=1193006035&oldid=prev
Mazewaxie: formatting
2024-01-01T15:11:14Z
<p>formatting</p>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Short description|Latin phrase referring to computer simulations}}</div></td>
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<td class="diff-marker"><a class="mw-diff-movedpara-left" title="Paragraph was moved. Click to jump to new location." href="#movedpara_3_0_rhs">⚫</a></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Other uses}}</div></td>
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<td class="diff-marker"><a class="mw-diff-movedpara-right" title="Paragraph was moved. Click to jump to old location." href="#movedpara_1_0_lhs">⚫</a></td>
<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><a name="movedpara_3_0_rhs"></a>{{italic title}}</div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Forest of synthetic pyramidal dendrites grown using Cajal's laws of neuronal branching.png|thumb|A forest of synthetic [[pyramidal cell|pyramidal]] [[dendrite]]s generated ''in silico'' using [[Santiago Ramón y Cajal|Cajal]]'s laws of neuronal branching]]</div></td>
<td class="diff-marker"></td>
<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[File:Forest of synthetic pyramidal dendrites grown using Cajal's laws of neuronal branching.png|thumb|A forest of synthetic [[pyramidal cell|pyramidal]] [[dendrite]]s generated ''in silico'' using [[Santiago Ramón y Cajal|Cajal]]'s laws of neuronal branching]]</div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td>
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</table>
Mazewaxie
https://en.wikipedia.org/w/index.php?title=In_silico&diff=1188168660&oldid=prev
Citation bot: Add: doi-access. | Use this bot. Report bugs. | #UCB_CommandLine
2023-12-03T19:26:16Z
<p>Add: doi-access. | <a href="/wiki/Wikipedia:UCB" class="mw-redirect" title="Wikipedia:UCB">Use this bot</a>. <a href="/wiki/Wikipedia:DBUG" class="mw-redirect" title="Wikipedia:DBUG">Report bugs</a>. | #UCB_CommandLine</p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Cell models==</div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td>
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<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Efforts have been made to establish computer models of cellular behavior. For example, in 2007 researchers developed an in silico model of [[tuberculosis]] to aid in drug discovery, with the prime benefit of its being faster than real time simulated growth rates, allowing phenomena of interest to be observed in minutes rather than months.<ref>University Of Surrey. June 25, 2007. [https://www.sciencedaily.com/releases/2007/06/070624135714.htm In Silico Cell For TB Drug Discovery]. ''ScienceDaily''. Retrieved February 12, 2010.</ref> More work can be found that focus on modeling a particular cellular process such as the growth cycle of ''[[Caulobacter crescentus]]''.<ref>{{cite journal | last1 = Li | first1 = S | last2 = Brazhnik | first2 = P | last3 = Sobral | first3 = B | last4 = Tyson | first4 = JJ | author4-link = John J. Tyson | year = 2009 | title = Temporal Controls of the Asymmetric Cell Division Cycle in Caulobacter crescentus | journal = PLOS Comput Biol | volume = 5 | issue = 8| page = e1000463 | doi = 10.1371/journal.pcbi.1000463 | pmid = 19680425 | pmc = 2714070 | bibcode = 2009PLSCB...5E0463L }}</ref></div></td>
<td class="diff-marker" data-marker="+"></td>
<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Efforts have been made to establish computer models of cellular behavior. For example, in 2007 researchers developed an in silico model of [[tuberculosis]] to aid in drug discovery, with the prime benefit of its being faster than real time simulated growth rates, allowing phenomena of interest to be observed in minutes rather than months.<ref>University Of Surrey. June 25, 2007. [https://www.sciencedaily.com/releases/2007/06/070624135714.htm In Silico Cell For TB Drug Discovery]. ''ScienceDaily''. Retrieved February 12, 2010.</ref> More work can be found that focus on modeling a particular cellular process such as the growth cycle of ''[[Caulobacter crescentus]]''.<ref>{{cite journal | last1 = Li | first1 = S | last2 = Brazhnik | first2 = P | last3 = Sobral | first3 = B | last4 = Tyson | first4 = JJ | author4-link = John J. Tyson | year = 2009 | title = Temporal Controls of the Asymmetric Cell Division Cycle in Caulobacter crescentus | journal = PLOS Comput Biol | volume = 5 | issue = 8| page = e1000463 | doi = 10.1371/journal.pcbi.1000463 | pmid = 19680425 | pmc = 2714070 | bibcode = 2009PLSCB...5E0463L<ins style="font-weight: bold; text-decoration: none;"> | doi-access = free</ins> }}</ref></div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>These efforts fall far short of an exact, fully predictive computer model of a cell's entire behavior. Limitations in the understanding of [[molecular dynamics]] and [[cell biology]], as well as the absence of available computer processing power, force large simplifying assumptions that constrain the usefulness of present in silico cell models.</div></td>
<td class="diff-marker"></td>
<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>These efforts fall far short of an exact, fully predictive computer model of a cell's entire behavior. Limitations in the understanding of [[molecular dynamics]] and [[cell biology]], as well as the absence of available computer processing power, force large simplifying assumptions that constrain the usefulness of present in silico cell models.</div></td>
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Citation bot
https://en.wikipedia.org/w/index.php?title=In_silico&diff=1170362853&oldid=prev
Nedmath: /* Cell models */ added commas to improve readability
2023-08-14T16:27:42Z
<p><span class="autocomment">Cell models: </span> added commas to improve readability</p>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Efforts have been made to establish computer models of cellular behavior. For example, in 2007 researchers developed an in silico model of [[tuberculosis]] to aid in drug discovery, with the prime benefit of its being faster than real time simulated growth rates, allowing phenomena of interest to be observed in minutes rather than months.<ref>University Of Surrey. June 25, 2007. [https://www.sciencedaily.com/releases/2007/06/070624135714.htm In Silico Cell For TB Drug Discovery]. ''ScienceDaily''. Retrieved February 12, 2010.</ref> More work can be found that focus on modeling a particular cellular process such as the growth cycle of ''[[Caulobacter crescentus]]''.<ref>{{cite journal | last1 = Li | first1 = S | last2 = Brazhnik | first2 = P | last3 = Sobral | first3 = B | last4 = Tyson | first4 = JJ | author4-link = John J. Tyson | year = 2009 | title = Temporal Controls of the Asymmetric Cell Division Cycle in Caulobacter crescentus | journal = PLOS Comput Biol | volume = 5 | issue = 8| page = e1000463 | doi = 10.1371/journal.pcbi.1000463 | pmid = 19680425 | pmc = 2714070 | bibcode = 2009PLSCB...5E0463L }}</ref></div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Efforts have been made to establish computer models of cellular behavior. For example, in 2007 researchers developed an in silico model of [[tuberculosis]] to aid in drug discovery, with the prime benefit of its being faster than real time simulated growth rates, allowing phenomena of interest to be observed in minutes rather than months.<ref>University Of Surrey. June 25, 2007. [https://www.sciencedaily.com/releases/2007/06/070624135714.htm In Silico Cell For TB Drug Discovery]. ''ScienceDaily''. Retrieved February 12, 2010.</ref> More work can be found that focus on modeling a particular cellular process such as the growth cycle of ''[[Caulobacter crescentus]]''.<ref>{{cite journal | last1 = Li | first1 = S | last2 = Brazhnik | first2 = P | last3 = Sobral | first3 = B | last4 = Tyson | first4 = JJ | author4-link = John J. Tyson | year = 2009 | title = Temporal Controls of the Asymmetric Cell Division Cycle in Caulobacter crescentus | journal = PLOS Comput Biol | volume = 5 | issue = 8| page = e1000463 | doi = 10.1371/journal.pcbi.1000463 | pmid = 19680425 | pmc = 2714070 | bibcode = 2009PLSCB...5E0463L }}</ref></div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td>
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<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>These efforts fall far short of an exact, fully predictive computer model of a cell's entire behavior. Limitations in the understanding of [[molecular dynamics]] and [[cell biology]] as well as the absence of available computer processing power force large simplifying assumptions that constrain the usefulness of present in silico cell models.</div></td>
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<td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>These efforts fall far short of an exact, fully predictive computer model of a cell's entire behavior. Limitations in the understanding of [[molecular dynamics]] and [[cell biology]]<ins style="font-weight: bold; text-decoration: none;">,</ins> as well as the absence of available computer processing power<ins style="font-weight: bold; text-decoration: none;">,</ins> force large simplifying assumptions that constrain the usefulness of present in silico cell models.</div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td>
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Nedmath
https://en.wikipedia.org/w/index.php?title=In_silico&diff=1167386990&oldid=prev
MrOllie: Restored revision 1127330906 by InternetArchiveBot (talk): Predatory publisher
2023-07-27T12:35:08Z
<p>Restored revision 1127330906 by <a href="/wiki/Special:Contributions/InternetArchiveBot" title="Special:Contributions/InternetArchiveBot">InternetArchiveBot</a> (<a href="/wiki/User_talk:InternetArchiveBot" title="User talk:InternetArchiveBot">talk</a>): Predatory publisher</p>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Validation of taxonomic assignment steps in herbivore metagenomics study.<ref>{{cite journal |last1=Chua |first1=Physilia Y. S. |last2=Crampton-Platt |first2=Alex |last3=Lammers |first3=Youri |last4=Alsos |first4=Inger G. |last5=Boessenkool |first5=Sanne |last6=Bohmann |first6=Kristine |title=Metagenomics: A viable tool for reconstructing herbivore diet |journal=Molecular Ecology Resources |year=2021 |volume=21 |issue=7 |pages=2249–2263 |doi=10.1111/1755-0998.13425 |pmc=8518049|pmid=33971086 |doi-access=free }}</ref></div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Validation of taxonomic assignment steps in herbivore metagenomics study.<ref>{{cite journal |last1=Chua |first1=Physilia Y. S. |last2=Crampton-Platt |first2=Alex |last3=Lammers |first3=Youri |last4=Alsos |first4=Inger G. |last5=Boessenkool |first5=Sanne |last6=Bohmann |first6=Kristine |title=Metagenomics: A viable tool for reconstructing herbivore diet |journal=Molecular Ecology Resources |year=2021 |volume=21 |issue=7 |pages=2249–2263 |doi=10.1111/1755-0998.13425 |pmc=8518049|pmid=33971086 |doi-access=free }}</ref></div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Protein design. One example is RosettaDesign, a software package under development and free for academic use.<ref>{{Citation |title=RosettaDesign server for protein design |journal=Nucleic Acids Research |volume=34 |issue=Web Server issue |pages=W235–8 |date=July 2006 |pmc=1538902 |doi=10.1093/nar/gkl163 |pmid=16845000 |last1=Liu |first1=Y |last2=Kuhlman |first2=B}}</ref><ref>{{Citation |doi=10.1016/S0022-2836(03)00888-X |title=A Large Scale Test of Computational Protein Design: Folding and Stability of Nine Completely Redesigned Globular Proteins |year=2003 |last1=Dantas |first1=Gautam |last2=Kuhlman |first2=Brian |last3=Callender |first3=David |last4=Wong |first4=Michelle |last5=Baker |first5=David |journal=Journal of Molecular Biology |volume=332 |pages=449–60 |postscript=. |pmid=12948494 |issue=2|citeseerx=10.1.1.66.8110 }}</ref><ref>{{Citation |doi=10.1016/j.str.2006.02.011 |title=High-Resolution Structural Validation of the Computational Redesign of Human U1A Protein |year=2006 |last1=Dobson |first1=N |last2=Dantas |first2=G |last3=Baker |first3=D |last4=Varani |first4=G |journal=Structure |volume=14 |pages=847–56 |postscript=. |pmid=16698546 |issue=5|doi-access=free }}</ref><ref>{{Citation |doi=10.1016/j.jmb.2006.11.080 |title=High-resolution Structural and Thermodynamic Analysis of Extreme Stabilization of Human Procarboxypeptidase by Computational Protein Design |year=2007 |last1=Dantas |first1=G |last2=Corrent |first2=C |last3=Reichow |first3=S |last4=Havranek |first4=J |last5=Eletr |first5=Z |last6=Isern |first6=N |last7=Kuhlman |first7=B |last8=Varani |first8=G |last9=Merritt |first9=E |last10=Baker |first10=David |journal=Journal of Molecular Biology |volume=366 |pages=1209–21 |postscript=. |pmid=17196978 |issue=4|display-authors=8 |pmc=3764424 }}</ref></div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Protein design. One example is RosettaDesign, a software package under development and free for academic use.<ref>{{Citation |title=RosettaDesign server for protein design |journal=Nucleic Acids Research |volume=34 |issue=Web Server issue |pages=W235–8 |date=July 2006 |pmc=1538902 |doi=10.1093/nar/gkl163 |pmid=16845000 |last1=Liu |first1=Y |last2=Kuhlman |first2=B}}</ref><ref>{{Citation |doi=10.1016/S0022-2836(03)00888-X |title=A Large Scale Test of Computational Protein Design: Folding and Stability of Nine Completely Redesigned Globular Proteins |year=2003 |last1=Dantas |first1=Gautam |last2=Kuhlman |first2=Brian |last3=Callender |first3=David |last4=Wong |first4=Michelle |last5=Baker |first5=David |journal=Journal of Molecular Biology |volume=332 |pages=449–60 |postscript=. |pmid=12948494 |issue=2|citeseerx=10.1.1.66.8110 }}</ref><ref>{{Citation |doi=10.1016/j.str.2006.02.011 |title=High-Resolution Structural Validation of the Computational Redesign of Human U1A Protein |year=2006 |last1=Dobson |first1=N |last2=Dantas |first2=G |last3=Baker |first3=D |last4=Varani |first4=G |journal=Structure |volume=14 |pages=847–56 |postscript=. |pmid=16698546 |issue=5|doi-access=free }}</ref><ref>{{Citation |doi=10.1016/j.jmb.2006.11.080 |title=High-resolution Structural and Thermodynamic Analysis of Extreme Stabilization of Human Procarboxypeptidase by Computational Protein Design |year=2007 |last1=Dantas |first1=G |last2=Corrent |first2=C |last3=Reichow |first3=S |last4=Havranek |first4=J |last5=Eletr |first5=Z |last6=Isern |first6=N |last7=Kuhlman |first7=B |last8=Varani |first8=G |last9=Merritt |first9=E |last10=Baker |first10=David |journal=Journal of Molecular Biology |volume=366 |pages=1209–21 |postscript=. |pmid=17196978 |issue=4|display-authors=8 |pmc=3764424 }}</ref></div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==See also==</div></td>
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MrOllie
https://en.wikipedia.org/w/index.php?title=In_silico&diff=1167379465&oldid=prev
84.67.8.88: /* Other examples */ Add references to cancer and tumor microenvironment
2023-07-27T11:19:33Z
<p><span class="autocomment">Other examples: </span> Add references to cancer and tumor microenvironment</p>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Validation of taxonomic assignment steps in herbivore metagenomics study.<ref>{{cite journal |last1=Chua |first1=Physilia Y. S. |last2=Crampton-Platt |first2=Alex |last3=Lammers |first3=Youri |last4=Alsos |first4=Inger G. |last5=Boessenkool |first5=Sanne |last6=Bohmann |first6=Kristine |title=Metagenomics: A viable tool for reconstructing herbivore diet |journal=Molecular Ecology Resources |year=2021 |volume=21 |issue=7 |pages=2249–2263 |doi=10.1111/1755-0998.13425 |pmc=8518049|pmid=33971086 |doi-access=free }}</ref></div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Protein design. One example is RosettaDesign, a software package under development and free for academic use.<ref>{{Citation |title=RosettaDesign server for protein design |journal=Nucleic Acids Research |volume=34 |issue=Web Server issue |pages=W235–8 |date=July 2006 |pmc=1538902 |doi=10.1093/nar/gkl163 |pmid=16845000 |last1=Liu |first1=Y |last2=Kuhlman |first2=B}}</ref><ref>{{Citation |doi=10.1016/S0022-2836(03)00888-X |title=A Large Scale Test of Computational Protein Design: Folding and Stability of Nine Completely Redesigned Globular Proteins |year=2003 |last1=Dantas |first1=Gautam |last2=Kuhlman |first2=Brian |last3=Callender |first3=David |last4=Wong |first4=Michelle |last5=Baker |first5=David |journal=Journal of Molecular Biology |volume=332 |pages=449–60 |postscript=. |pmid=12948494 |issue=2|citeseerx=10.1.1.66.8110 }}</ref><ref>{{Citation |doi=10.1016/j.str.2006.02.011 |title=High-Resolution Structural Validation of the Computational Redesign of Human U1A Protein |year=2006 |last1=Dobson |first1=N |last2=Dantas |first2=G |last3=Baker |first3=D |last4=Varani |first4=G |journal=Structure |volume=14 |pages=847–56 |postscript=. |pmid=16698546 |issue=5|doi-access=free }}</ref><ref>{{Citation |doi=10.1016/j.jmb.2006.11.080 |title=High-resolution Structural and Thermodynamic Analysis of Extreme Stabilization of Human Procarboxypeptidase by Computational Protein Design |year=2007 |last1=Dantas |first1=G |last2=Corrent |first2=C |last3=Reichow |first3=S |last4=Havranek |first4=J |last5=Eletr |first5=Z |last6=Isern |first6=N |last7=Kuhlman |first7=B |last8=Varani |first8=G |last9=Merritt |first9=E |last10=Baker |first10=David |journal=Journal of Molecular Biology |volume=366 |pages=1209–21 |postscript=. |pmid=17196978 |issue=4|display-authors=8 |pmc=3764424 }}</ref></div></td>
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<td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Protein design. One example is RosettaDesign, a software package under development and free for academic use.<ref>{{Citation |title=RosettaDesign server for protein design |journal=Nucleic Acids Research |volume=34 |issue=Web Server issue |pages=W235–8 |date=July 2006 |pmc=1538902 |doi=10.1093/nar/gkl163 |pmid=16845000 |last1=Liu |first1=Y |last2=Kuhlman |first2=B}}</ref><ref>{{Citation |doi=10.1016/S0022-2836(03)00888-X |title=A Large Scale Test of Computational Protein Design: Folding and Stability of Nine Completely Redesigned Globular Proteins |year=2003 |last1=Dantas |first1=Gautam |last2=Kuhlman |first2=Brian |last3=Callender |first3=David |last4=Wong |first4=Michelle |last5=Baker |first5=David |journal=Journal of Molecular Biology |volume=332 |pages=449–60 |postscript=. |pmid=12948494 |issue=2|citeseerx=10.1.1.66.8110 }}</ref><ref>{{Citation |doi=10.1016/j.str.2006.02.011 |title=High-Resolution Structural Validation of the Computational Redesign of Human U1A Protein |year=2006 |last1=Dobson |first1=N |last2=Dantas |first2=G |last3=Baker |first3=D |last4=Varani |first4=G |journal=Structure |volume=14 |pages=847–56 |postscript=. |pmid=16698546 |issue=5|doi-access=free }}</ref><ref>{{Citation |doi=10.1016/j.jmb.2006.11.080 |title=High-resolution Structural and Thermodynamic Analysis of Extreme Stabilization of Human Procarboxypeptidase by Computational Protein Design |year=2007 |last1=Dantas |first1=G |last2=Corrent |first2=C |last3=Reichow |first3=S |last4=Havranek |first4=J |last5=Eletr |first5=Z |last6=Isern |first6=N |last7=Kuhlman |first7=B |last8=Varani |first8=G |last9=Merritt |first9=E |last10=Baker |first10=David |journal=Journal of Molecular Biology |volume=366 |pages=1209–21 |postscript=. |pmid=17196978 |issue=4|display-authors=8 |pmc=3764424 }}</ref></div></td>
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84.67.8.88