RS-67,333 - Revision history

Michael7604: recategorized from Chlorobenzenes to Chlorobenzene derivatives

2024-02-04T01:42:24Z

recategorized from Chlorobenzenes to Chlorobenzene derivatives

← Previous revision		Revision as of 01:42, 4 February 2024
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	[[Category:Sigma agonists]]		[[Category:Sigma agonists]]
	[[Category:Aromatic ketones]]		[[Category:Aromatic ketones]]
	[[Category:~~Chlorobenzenes~~]]		[[Category:Chlorobenzene derivatives]]
	[[Category:Phenol ethers]]		[[Category:Phenol ethers]]


	{{nervous-system-drug-stub}}		{{nervous-system-drug-stub}}

Fswitzer4: Added UNII and CAS No in Drugbox

2022-09-01T15:19:11Z

Added UNII and CAS No in Drugbox

← Previous revision		Revision as of 15:19, 1 September 2022
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	\| IUPAC_name = 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-1-propanone		\| IUPAC_name = 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-1-propanone
	\| image = RS 67333.png		\| image = RS 67333.png
⚫	\| CAS_number_Ref = {{cascite\|correct\|CAS}}
⚫	\| CAS_number = 160845-95-4
⚫	\| UNII_Ref = {{fdacite\|correct\|FDA}}
⚫	\| UNII = 39N8XG5C9A

	<!--Clinical data-->		<!--Clinical data-->
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	<!--Identifiers-->		<!--Identifiers-->
		⚫	\| CAS_number_Ref = {{cascite\|correct\|CAS}}
		⚫	\| CAS_number = 160845-95-4
		⚫	\| UNII_Ref = {{fdacite\|correct\|FDA}}
		⚫	\| UNII = 39N8XG5C9A
	\| ATC_prefix =		\| ATC_prefix =
	\| ATC_suffix =		\| ATC_suffix =

Davemck: rmv duplicate parms

2022-08-31T21:45:49Z

rmv duplicate parms

← Previous revision		Revision as of 21:45, 31 August 2022
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	<!--Identifiers-->		<!--Identifiers-->
	\| CAS_number_Ref = {{cascite\|correct\|??}}
	\| CAS_number = 160845-95-4
	\| ATC_prefix =		\| ATC_prefix =
	\| ATC_suffix =		\| ATC_suffix =

Fswitzer4: Added UNII and CAS No in Drugbox

2022-08-31T17:18:00Z

Added UNII and CAS No in Drugbox

← Previous revision		Revision as of 17:18, 31 August 2022
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	\| IUPAC_name = 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-1-propanone		\| IUPAC_name = 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-1-propanone
	\| image = RS 67333.png		\| image = RS 67333.png
			\| CAS_number_Ref = {{cascite\|correct\|CAS}}
			\| CAS_number = 160845-95-4
			\| UNII_Ref = {{fdacite\|correct\|FDA}}
			\| UNII = 39N8XG5C9A

	<!--Clinical data-->		<!--Clinical data-->

Ffffrr: Importing Wikidata short description: "Chemical compound"

2022-08-22T08:58:33Z

Importing Wikidata short description: "Chemical compound"

← Previous revision		Revision as of 08:58, 22 August 2022
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			{{Short description\|Chemical compound}}
	{{Drugbox		{{Drugbox
	\| Verifiedfields = changed		\| Verifiedfields = changed

Nucleus hydro elemon: Moving from Category:Chloroarenes to Category:Chlorobenzenes using Cat-a-lot

2022-02-14T14:53:03Z

Moving from Category:Chloroarenes to Category:Chlorobenzenes using Cat-a-lot

← Previous revision		Revision as of 14:53, 14 February 2022
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	[[Category:Sigma agonists]]		[[Category:Sigma agonists]]
	[[Category:Aromatic ketones]]		[[Category:Aromatic ketones]]
	[[Category:~~Chloroarenes~~]]		[[Category:Chlorobenzenes]]
	[[Category:Phenol ethers]]		[[Category:Phenol ethers]]

OAbot: Open access bot: doi added to citation with #oabot.

2021-07-05T04:29:59Z

Open access bot: doi added to citation with #oabot.

← Previous revision		Revision as of 04:29, 5 July 2021
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	}}		}}

	'''RS-67,333''' is a [[drug]] which has been investigated as a potential rapid-acting [[antidepressant]],<ref name="antidepressant-Lucas">{{cite journal \| vauthors=Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G \| title=Serotonin(4) (5-HT(4)) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action. \| journal=Neuron \| year=2007 \| pages=712–25 \| volume=55 \| issue=5 \| pmid=17785179 \| doi=10.1016/j.neuron.2007.07.041\| s2cid=14558104 }}</ref> [[nootropic]],<ref name="nootropic-Lamirault">{{cite journal \| vauthors=Lamirault L, Simon H \| title=Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors. \| journal=Neuropharmacology \| year=2001 \| pages=844–53 \| volume=41 \| issue=7 \| pmid=11684148 \| doi=10.1016/S0028-3908(01)00123-X\| s2cid=31707593 }}</ref> and treatment for [[Alzheimer's disease]].<ref name="alzheimers-Cho">{{cite journal \| vauthors=Cho S, Hu Y \| title=Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival. \| journal=Experimental Neurology \| year=2007 \| pages=274–8 \| volume=203 \| issue=1 \| pmid=16978609 \| doi=10.1016/j.expneurol.2006.07.021\| s2cid=41975593 }}</ref> It is a high-affinity [[5-HT receptor\|5-HT4 receptor]] [[partial agonist]], as well as a [[sigma receptor]] [[ligand (biochemistry)\|ligand]] of both subtypes to a lesser extent.<ref name="pmid8564196">{{cite journal \|vauthors=Eglen RM, Bonhaus DW, Johnson LG, Leung E, Clark RD \|title=Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo \|journal=Br. J. Pharmacol. \|volume=115 \|issue=8 \|pages=1387–92 \|date=August 1995 \|pmid=8564196 \|pmc=1908873 \|doi= 10.1111/j.1476-5381.1995.tb16628.x}}</ref>		'''RS-67,333''' is a [[drug]] which has been investigated as a potential rapid-acting [[antidepressant]],<ref name="antidepressant-Lucas">{{cite journal \| vauthors=Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G \| title=Serotonin(4) (5-HT(4)) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action. \| journal=Neuron \| year=2007 \| pages=712–25 \| volume=55 \| issue=5 \| pmid=17785179 \| doi=10.1016/j.neuron.2007.07.041\| s2cid=14558104 \| doi-access=free }}</ref> [[nootropic]],<ref name="nootropic-Lamirault">{{cite journal \| vauthors=Lamirault L, Simon H \| title=Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors. \| journal=Neuropharmacology \| year=2001 \| pages=844–53 \| volume=41 \| issue=7 \| pmid=11684148 \| doi=10.1016/S0028-3908(01)00123-X\| s2cid=31707593 }}</ref> and treatment for [[Alzheimer's disease]].<ref name="alzheimers-Cho">{{cite journal \| vauthors=Cho S, Hu Y \| title=Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival. \| journal=Experimental Neurology \| year=2007 \| pages=274–8 \| volume=203 \| issue=1 \| pmid=16978609 \| doi=10.1016/j.expneurol.2006.07.021\| s2cid=41975593 }}</ref> It is a high-affinity [[5-HT receptor\|5-HT4 receptor]] [[partial agonist]], as well as a [[sigma receptor]] [[ligand (biochemistry)\|ligand]] of both subtypes to a lesser extent.<ref name="pmid8564196">{{cite journal \|vauthors=Eglen RM, Bonhaus DW, Johnson LG, Leung E, Clark RD \|title=Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo \|journal=Br. J. Pharmacol. \|volume=115 \|issue=8 \|pages=1387–92 \|date=August 1995 \|pmid=8564196 \|pmc=1908873 \|doi= 10.1111/j.1476-5381.1995.tb16628.x}}</ref>

	==References==		==References==

Monkbot: Task 18 (cosmetic): eval 4 templates: del empty params (1×);

2020-12-01T16:54:03Z

Task 18 (cosmetic): eval 4 templates: del empty params (1×);

← Previous revision		Revision as of 16:54, 1 December 2020
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	}}		}}

	'''RS-67,333''' is a [[drug]] which has been investigated as a potential rapid-acting [[antidepressant]],<ref name="antidepressant-Lucas">{{cite journal \| vauthors=Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G \| title=Serotonin(4) (5-HT(4)) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action. \| journal=Neuron \| year=2007 \| pages=712–25 \| volume=55 \| issue=5 \| pmid=17785179 \| doi=10.1016/j.neuron.2007.07.041\| s2cid=14558104 }}</ref> [[nootropic]],<ref name="nootropic-Lamirault">{{cite journal \| vauthors=Lamirault L, Simon H \| title=Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors. \| journal=Neuropharmacology \| year=2001 \| pages=844–53 \| volume=41 \| issue=7 \| pmid=11684148 \| doi=10.1016/S0028-3908(01)00123-X\| s2cid=31707593 }}</ref> and treatment for [[Alzheimer's disease]].<ref name="alzheimers-Cho">{{cite journal \| vauthors=Cho S, Hu Y \| title=Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival. \| journal=Experimental Neurology \| year=2007 \| pages=274–8 \| volume=203 \| issue=1 \| pmid=16978609 \| doi=10.1016/j.expneurol.2006.07.021\| s2cid=41975593 }}</ref> It is a high-affinity [[5-HT receptor\|5-HT4 receptor]] [[partial agonist]], as well as a [[sigma receptor]] [[ligand (biochemistry)\|ligand]] of both subtypes to a lesser extent.<ref name="pmid8564196">{{cite journal \|vauthors=Eglen RM, Bonhaus DW, Johnson LG, Leung E, Clark RD \|title=Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo \|journal=Br. J. Pharmacol. \|volume=115 \|issue=8 \|pages=1387–92 \|date=August 1995 \|pmid=8564196 \|pmc=1908873 \|doi= 10.1111/j.1476-5381.1995.tb16628.x~~\|url=~~}}</ref>		'''RS-67,333''' is a [[drug]] which has been investigated as a potential rapid-acting [[antidepressant]],<ref name="antidepressant-Lucas">{{cite journal \| vauthors=Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G \| title=Serotonin(4) (5-HT(4)) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action. \| journal=Neuron \| year=2007 \| pages=712–25 \| volume=55 \| issue=5 \| pmid=17785179 \| doi=10.1016/j.neuron.2007.07.041\| s2cid=14558104 }}</ref> [[nootropic]],<ref name="nootropic-Lamirault">{{cite journal \| vauthors=Lamirault L, Simon H \| title=Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors. \| journal=Neuropharmacology \| year=2001 \| pages=844–53 \| volume=41 \| issue=7 \| pmid=11684148 \| doi=10.1016/S0028-3908(01)00123-X\| s2cid=31707593 }}</ref> and treatment for [[Alzheimer's disease]].<ref name="alzheimers-Cho">{{cite journal \| vauthors=Cho S, Hu Y \| title=Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival. \| journal=Experimental Neurology \| year=2007 \| pages=274–8 \| volume=203 \| issue=1 \| pmid=16978609 \| doi=10.1016/j.expneurol.2006.07.021\| s2cid=41975593 }}</ref> It is a high-affinity [[5-HT receptor\|5-HT4 receptor]] [[partial agonist]], as well as a [[sigma receptor]] [[ligand (biochemistry)\|ligand]] of both subtypes to a lesser extent.<ref name="pmid8564196">{{cite journal \|vauthors=Eglen RM, Bonhaus DW, Johnson LG, Leung E, Clark RD \|title=Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo \|journal=Br. J. Pharmacol. \|volume=115 \|issue=8 \|pages=1387–92 \|date=August 1995 \|pmid=8564196 \|pmc=1908873 \|doi= 10.1111/j.1476-5381.1995.tb16628.x}}</ref>

	==References==		==References==

Citation bot: Add: s2cid. | You can use this bot yourself. Report bugs here. | Suggested by Abductive | Category:Phenol ethers | via #UCB_Category

2020-09-23T05:32:48Z

Add: s2cid. | You can use this bot yourself. Report bugs here. | Suggested by Abductive | Category:Phenol ethers | via #UCB_Category

← Previous revision		Revision as of 05:32, 23 September 2020
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	}}		}}

	'''RS-67,333''' is a [[drug]] which has been investigated as a potential rapid-acting [[antidepressant]],<ref name="antidepressant-Lucas">{{cite journal \| vauthors=Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G \| title=Serotonin(4) (5-HT(4)) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action. \| journal=Neuron \| year=2007 \| pages=712–25 \| volume=55 \| issue=5 \| pmid=17785179 \| doi=10.1016/j.neuron.2007.07.041}}</ref> [[nootropic]],<ref name="nootropic-Lamirault">{{cite journal \| vauthors=Lamirault L, Simon H \| title=Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors. \| journal=Neuropharmacology \| year=2001 \| pages=844–53 \| volume=41 \| issue=7 \| pmid=11684148 \| doi=10.1016/S0028-3908(01)00123-X}}</ref> and treatment for [[Alzheimer's disease]].<ref name="alzheimers-Cho">{{cite journal \| vauthors=Cho S, Hu Y \| title=Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival. \| journal=Experimental Neurology \| year=2007 \| pages=274–8 \| volume=203 \| issue=1 \| pmid=16978609 \| doi=10.1016/j.expneurol.2006.07.021}}</ref> It is a high-affinity [[5-HT receptor\|5-HT4 receptor]] [[partial agonist]], as well as a [[sigma receptor]] [[ligand (biochemistry)\|ligand]] of both subtypes to a lesser extent.<ref name="pmid8564196">{{cite journal \|vauthors=Eglen RM, Bonhaus DW, Johnson LG, Leung E, Clark RD \|title=Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo \|journal=Br. J. Pharmacol. \|volume=115 \|issue=8 \|pages=1387–92 \|date=August 1995 \|pmid=8564196 \|pmc=1908873 \|doi= 10.1111/j.1476-5381.1995.tb16628.x\|url=}}</ref>		'''RS-67,333''' is a [[drug]] which has been investigated as a potential rapid-acting [[antidepressant]],<ref name="antidepressant-Lucas">{{cite journal \| vauthors=Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Piñeyro G, Sadikot AF, Debonnel G \| title=Serotonin(4) (5-HT(4)) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action. \| journal=Neuron \| year=2007 \| pages=712–25 \| volume=55 \| issue=5 \| pmid=17785179 \| doi=10.1016/j.neuron.2007.07.041\| s2cid=14558104 }}</ref> [[nootropic]],<ref name="nootropic-Lamirault">{{cite journal \| vauthors=Lamirault L, Simon H \| title=Enhancement of place and object recognition memory in young adult and old rats by RS 67333, a partial agonist of 5-HT4 receptors. \| journal=Neuropharmacology \| year=2001 \| pages=844–53 \| volume=41 \| issue=7 \| pmid=11684148 \| doi=10.1016/S0028-3908(01)00123-X\| s2cid=31707593 }}</ref> and treatment for [[Alzheimer's disease]].<ref name="alzheimers-Cho">{{cite journal \| vauthors=Cho S, Hu Y \| title=Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival. \| journal=Experimental Neurology \| year=2007 \| pages=274–8 \| volume=203 \| issue=1 \| pmid=16978609 \| doi=10.1016/j.expneurol.2006.07.021\| s2cid=41975593 }}</ref> It is a high-affinity [[5-HT receptor\|5-HT4 receptor]] [[partial agonist]], as well as a [[sigma receptor]] [[ligand (biochemistry)\|ligand]] of both subtypes to a lesser extent.<ref name="pmid8564196">{{cite journal \|vauthors=Eglen RM, Bonhaus DW, Johnson LG, Leung E, Clark RD \|title=Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo \|journal=Br. J. Pharmacol. \|volume=115 \|issue=8 \|pages=1387–92 \|date=August 1995 \|pmid=8564196 \|pmc=1908873 \|doi= 10.1111/j.1476-5381.1995.tb16628.x\|url=}}</ref>

	==References==		==References==

DMacks: Remove malformatted |molecular_weight= when infobox can autocalculate it, per Wikipedia talk:WikiProject Pharmacology#Molecular weights in drugboxes (via WP:JWB)

2020-06-23T19:48:48Z

Remove malformatted |molecular_weight= when infobox can autocalculate it, per Wikipedia talk:WikiProject Pharmacology#Molecular weights in drugboxes (via WP:JWB)

← Previous revision		Revision as of 19:48, 23 June 2020
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	<!--Chemical data-->		<!--Chemical data-->
	\| C=19 \| H=29 \| N=2 \| O=2 \| Cl=1		\| C=19 \| H=29 \| N=2 \| O=2 \| Cl=1
	\| molecular_weight = 352.9 g/mol
	\| smiles = C(CCC1CCN(CC1)CCCC)(=O)c1c(cc(c(c1)Cl)N)OC		\| smiles = C(CCC1CCN(CC1)CCCC)(=O)c1c(cc(c(c1)Cl)N)OC
	\| StdInChI_Ref = {{stdinchicite\|changed\|chemspider}}		\| StdInChI_Ref = {{stdinchicite\|changed\|chemspider}}