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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EXOSC8_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2nn6.
| PDB = {{PDB2|2nn6}}
| Name = Exosome component 8
| HGNCid = 17035
| Symbol = EXOSC8
| AltSymbols =; CIP3; EAP2; OIP2; RP11-421P11.3; RRP43; Rrp43p; bA421P11.3; p9
| OMIM = 606019
| ECnumber =
| Homologene = 12323
| MGIid = 1916889
| GeneAtlas_image1 = PBB_GE_EXOSC8_215136_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000175 |text = 3'-5'-exoribonuclease activity}} {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0004527 |text = exonuclease activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0000178 |text = exosome (RNase complex)}} {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006364 |text = rRNA processing}} {{GNF_GO|id=GO:0006396 |text = RNA processing}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 11340
| Hs_Ensembl = ENSG00000120699
| Hs_RefseqProtein = NP_852480
| Hs_RefseqmRNA = NM_181503
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 13
| Hs_GenLoc_start = 36472932
| Hs_GenLoc_end = 36481538
| Hs_Uniprot = Q96B26
| Mm_EntrezGene = 69639
| Mm_Ensembl = ENSMUSG00000027752
| Mm_RefseqmRNA = NM_027148
| Mm_RefseqProtein = NP_081424
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 54816607
| Mm_GenLoc_end = 54823322
| Mm_Uniprot = Q3TEB9
}}
}}
'''Exosome component 8''', also known as '''EXOSC8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EXOSC8 exosome component 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11340| accessdate = }}</ref>


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== June 2008 ==
{{PBB_Summary
[[Image:Information.svg|left|25px]] Welcome to Wikipedia. Although everyone is welcome to make constructive contributions to Wikipedia, at least one of your recent edits, such as the one you made to [[:Jousting]], did not appear to be constructive and has been '''automatically [[Help:Reverting|reverted]]''' by [[User:ClueBot|ClueBot]]. Please use [[Wikipedia:Sandbox|the sandbox]] for any test edits you would like to make, and take a look at the [[Wikipedia:Introduction|welcome page]] to learn more about contributing to this encyclopedia. '''If you believe there has been a mistake and would like to report a false positive, please [[User:ClueBot/FalsePositives|report it here]] and then remove this warning from your talk page.''' If your edit was not vandalism, please feel free to make your edit again after reporting it. The following is the log entry regarding this warning: [[Jousting]] was [http://en.wikipedia.org/w/index.php?title=Jousting&diff=218589641&oldid=217857995 changed] by [[Special:Contributions/220.237.151.97|220.237.151.97]] [[User:220.237.151.97|(u)]] [[User talk:220.237.151.97|(t)]] making a minor change adding "!!!" on 2008-06-11T09:27:51+00:00 <!-- MySQL ID: 414765 -->. Thank you. <!-- Template:uw-cluebotwarning1 --><!-- Template:uw-vandalism1 --> [[User:ClueBot|ClueBot]] ([[User talk:ClueBot|talk]]) 09:27, 11 June 2008 (UTC)
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==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ |title=Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. |journal=J. Mol. Biol. |volume=323 |issue= 4 |pages= 653–63 |year= 2002 |pmid= 12419256 |doi= }}
*{{cite journal | author=Jiang T, Altman S |title=A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 8 |pages= 5295–300 |year= 2002 |pmid= 11929972 |doi= 10.1073/pnas.072083699 }}
*{{cite journal | author=Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ |title=Protein-protein interactions of hCsl4p with other human exosome subunits. |journal=J. Mol. Biol. |volume=315 |issue= 4 |pages= 809–18 |year= 2002 |pmid= 11812149 |doi= 10.1006/jmbi.2001.5265 }}
*{{cite journal | author=Chen CY, Gherzi R, Ong SE, ''et al.'' |title=AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. |journal=Cell |volume=107 |issue= 4 |pages= 451–64 |year= 2002 |pmid= 11719186 |doi= }}
*{{cite journal | author=Jiang T, Altman S |title=Protein-protein interactions with subunits of human nuclear RNase P. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 3 |pages= 920–5 |year= 2001 |pmid= 11158571 |doi= 10.1073/pnas.021561498 }}
*{{cite journal | author=Brouwer R, Allmang C, Raijmakers R, ''et al.'' |title=Three novel components of the human exosome. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6177–84 |year= 2001 |pmid= 11110791 |doi= 10.1074/jbc.M007603200 }}
*{{cite journal | author=Williams JM, Chen GC, Zhu L, Rest RF |title=Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth. |journal=Mol. Microbiol. |volume=27 |issue= 1 |pages= 171–86 |year= 1998 |pmid= 9466265 |doi= }}
}}
{{refend}}

{{gene-13-stub}}

Revision as of 09:30, 11 June 2008

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EXOSC8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEXOSC8, CIP3, EAP2, OIP2, RRP43, Rrp43p, bA421P11.3, p9, PCH1C, Exosome component 8
External IDsOMIM: 606019; MGI: 1916889; HomoloGene: 12323; GeneCards: EXOSC8; OMA:EXOSC8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_181503

NM_001163570
NM_027148

RefSeq (protein)

NP_852480

NP_001157042
NP_081424

Location (UCSC)Chr 13: 37 – 37.03 MbChr 3: 54.64 – 54.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Exosome component 8, also known as EXOSC8, is a human gene.[5]

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References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120699Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027752Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: EXOSC8 exosome component 8".

Further reading