Chloroquine and Junichi Inamoto: Difference between pages

Junichi Inamoto
	Junichi Inamoto
Personal information
Height	1.81 m (5 ft 11 in)
Position(s)	Midfield
Team information
Current team	West Bromwich Albion
Number	33
	‡ National team caps and goals, correct as of 23 June 2006

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Revision as of 11:50, 2 August 2006

Junichi Inamoto (稲本潤一, Inamoto Jun'ichi, born September 18, 1979) is a Japanese association football player who plays in midfield for West Bromwich Albion.

Inamoto played for Japanese club Gamba Osaka during his last year of high school, signing with the club in 1998. He was then one of many high profile transfers of Asian players to Europe, signing with Arsenal of the FA Premier League, though he failed to break into the first team, only ever appearing in the Carling Cup. Inamoto scored two goals for the Japanese National Team at the 2002 World Cup, but was released by Arsenal shortly after. He was then signed by Fulham on a long-term loan deal from Gamba Osaka. Initially he settled well at the London club, garnering good notices as a tough-tackling midfielder with an eye for a spectacular goal. However, he sustained a fractured tibia in an international friendly against England, and returned to Gamba Osaka to do promotional work. Fulham were interested in signing him once more, but concerns remained over his recovery from injury.

Inamoto ended up signing with West Bromwich Albion for a decidedly small £200,000 transfer fee, which was only to be paid once he had made an appearance for the Midlands club. However, Gary Megson departed as West Bromwich Albion manager shortly afterwards, and successor Bryan Robson was unsure of the Japanese's talent. Inamoto was loaned to Cardiff City F.C. for the latter part of the 2004-05 season, and impressed, being recalled to play a role in WBA's survival campaign in the Premiership. In 2005-06 he was a regular in the West Brom side, and was called up to the Japan squad for the 2006 FIFA World Cup, the first Albion player to play in the tournament for 20 years.

Clubs

Cardiff City F.C. (2005 loan)
West Bromwich Albion F.C. (2004-)
Fulham F.C. (2002-2003)
Arsenal F.C. (2001-2002)
Gamba Osaka (1998-2002)
Seiei Gakuen S.C.

Honors and awards

FIFA World Youth Championship runner-up: 1999

External links

Profile at West Bromwich Albion's official site
Statistics at soccerbase.com
Inamoto: The ups and downs

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+{{Football player infobox
-{{cleanup-date|February 2006}}
+| playername = Junichi Inamoto
-{{drugbox | IUPAC_name = ''N'''-(7-chloroquinolin-4-yl)-''N'',''N''-diethyl-pentane-1,4-diamine | image = {{PAGENAME}}.svg | CAS_number = 54-05-7 | ATC_prefix = P01 | ATC_suffix = BA01 | PubChem = 2719 | DrugBank = APRD00468 | C = 18 |H = 26 |Cl = 1 |N = 3 | molecular_weight = 319.872 [[Gram|g]]/[[Mole (unit)|mol]] | bioavailability = | protein_bound = | metabolism = | elimination_half-life = 1-2 months | pregnancy_category = | legal_status = | routes_of_administration = }}
+| image = [[Image:Inamoto.jpg|Junichi Inamoto]]
+| fullname =
+| height = 181 cm
+| nickname = Ina
+| dateofbirth = [[September 18]], [[1979]]
+| cityofbirth = [[Yusui, Kagoshima]]
+| countryofbirth = [[Japan]]
+| currentclub = [[West Bromwich Albion F.C.|West Bromwich Albion]]
+| clubnumber = 33
+| position = Midfield
+| youthyears =
+| youthclubs =
+| years = [[1997]]-[[2001]]<br>[[2001]]-[[2002]]<br>[[2002]]-[[2004]]<br>[[2004]]-present
+| clubs = [[Gamba Osaka]]<br>[[Arsenal F.C.|Arsenal]]<br>[[Fulham F.C.|Fulham]]<br>[[West Bromwich Albion F.C.|West Bromwich Albion]]
+| caps(goals) = 118 (16)<br>0 (0)<br>47 (4)<br>25 (0){{dubious}}<!---Caps and goal figures above likely contain European cup/Domestic cup data in addition to Domestic League data. Please correct this issue and leave a note [http://en.wikipedia.org/wiki/User_talk:Alfmaster#Footballers.27_European_goals!!!|here] to warn this person about putting improper information on Wikipedia--->
+| nationalyears = [[2000]]-
+| nationalteam = [[Japan national football team|Japan]]
+| nationalcaps(goals) = 65 (4)
+| pcupdate = 23:58, 5 April 2006 (UTC)
+| ntupdate = 23 June 2006
+}}
+{{nihongo|'''Junichi Inamoto'''|稲本 潤一|Inamoto Jun'ichi|extra=born [[September 18]], [[1979]]}} is a [[Japan]]ese [[football (soccer)|association football]] player who plays in [[midfielder (soccer)|midfield]] for [[West Bromwich Albion F.C.|West Bromwich Albion]].
-'''Chloroquine''' is a commonly used form of [[medication]] against [[malaria]]. As it also mildly suppresses the [[immune system]], it is used in some [[autoimmune disorder]]s, such as [[rheumatoid arthritis]] and [[Lupus erythematosus]].
+Inamoto played for Japanese club [[Gamba Osaka]] during his last year of high school, signing with the club in 1998. He was then one of many high profile transfers of Asian players to Europe, signing with [[Arsenal F.C.|Arsenal]] of the [[FA Premier League]], though he failed to break into the first team, only ever appearing in the Carling Cup. Inamoto scored two goals for the [[Japan national football team|Japanese National Team]] at the [[2002 World Cup]], but was released by Arsenal shortly after. He was then signed by [[Fulham F.C.|Fulham]] on a long-term loan deal from [[Gamba Osaka]]. Initially he settled well at the London club, garnering good notices as a tough-tackling midfielder with an eye for a spectacular goal. However, he sustained a fractured [[tibia]] in an international friendly against [[England national football team|England]], and returned to [[Gamba Osaka]] to do promotional work. [[Fulham F.C.|Fulham]] were interested in signing him once more, but concerns remained over his recovery from injury.
-==Pharmacology==
-Chloroquine has a very high [[volume of distribution]], as it diffuses into the body's [[adipose tissue]].  Chloroquine and related quinines have been associated with cases of [[retina|retinal]] toxicity, particularly when provided at higher doses for longer timeframes.  Accumulation of the drug may result in deposits that can lead to blurred vision and [[blindness]].  With long term doses, routine visits to an [[ophthalmologist]] are recommended.
+Inamoto ended up signing with [[West Bromwich Albion F.C.|West Bromwich Albion]] for a decidedly small £200,000 transfer fee, which was only to be paid once he had made an appearance for the Midlands club. However, [[Gary Megson]] departed as West Bromwich Albion manager shortly afterwards, and successor [[Bryan Robson]] was unsure of the Japanese's talent. Inamoto was loaned to [[Cardiff City F.C.]] for the latter part of the [[2004-05 in English football|2004-05]] season, and impressed, being recalled to play a role in WBA's survival campaign in the Premiership. In [[2005-06 in English football|2005-06]] he was a regular in the West Brom side, and was called up to the Japan squad for the [[2006 FIFA World Cup]], the first Albion player to play in the tournament for 20 years.
-==Malaria prevention==
-Chloroquine can be used for preventing malaria from ''[[Plasmodium]] [[Plasmodium vivax|vivax]]'', ''[[Plasmodium ovale|ovale]]'' and ''[[Plasmodium malariae|malariae]]''.  Many areas of the world have widespread strains of chloroquine-resistant [[Plasmodium falciparum]], so other [[antimalarials]] like [[mefloquine]] or [[atovaquone]] may be advisable instead. Combining chloroquine with [[proguanil]] may be more effective against chloroquine-resistant [[Plasmodium falciparum]] than treatment with chloroquine alone, but is no longer reccomended by the [[CDC]] due to the availability of more effective combinations. <ref> CDC. Health information for international travel 2001--2002. Atlanta, Georgia: US Department of Health and Human Services, Public Health Service, 2001. </ref>
-==Side effects==
+==Clubs==
+*[[Cardiff City F.C.]] (2005 loan)
-At the doses used for prevention of malaria, [[adverse drug reaction|side effects]] include gastrointestinal problems such as [[Abdominal pain|stomach ache]], [[itch]], [[headache]] and [[Cycloplegia|blurred vision]]. These may be more pronounced with higher doses used for treatment. Chloroquine tablets have an unpleasant metallic taste.
+*[[West Bromwich Albion F.C.]] (2004-)
+*[[Fulham F.C.]] (2002-2003)
+*[[Arsenal F.C.]] (2001-2002)
+*[[Gamba Osaka]] (1998-2002)
+*[[Seiei Gakuen S.C.]]
-==Mechanism of action==
+==Honors and awards==
+*[[FIFA World Youth Championship]] runner-up: 1999
-Inside the [[red blood cell]]s, the malarial [[parasite]] must degrade the [[hemoglobin]] for the acquisition of essential amino acids, which the parasite requires to construct its own protein and for energy metabolism. This is essential for parasitical growth and division inside the red blood cell. It is carried out in the digestive vacuole of the parasite cell.
+==External links==
-During this process, the parasite produces the toxic and soluble molecule [[heme]]. The heme moiety consists of a porphyrin ring called Fe(II)-protoporphyrin IX (FP). To avoid destruction by this molecule, the parasite polymerises heme to form [http://jhmalaria.jhsph.edu/hemozoin/ hemozoin], a non-toxic molecule. Hemozoin collects in the digestive vacuole as insoluble crystals.
+*[http://www.wba.premiumtv.co.uk/page/Squad/PlayersDetail/0,,10366~16053,00.html Profile at West Bromwich Albion's official site]
+*[http://www.soccerbase.com/players_details.sd?playerid=20824 Statistics] at soccerbase.com
+*[http://www.mymackspace.com/uploads/images/junichi.jpg/?id=7230&display_set=eng Inamoto: The ups and downs]
+{{Japan Squad 2002 World Cup}}
-Chloroquine enters the red blood cell, inhabiting parasite cell, and digestive vacuole by simple diffusion. Chloroquine then becomes protonated (to CQ2+) as the digestive vacuole is known to be acidic (pH 4.7), chloroquine then cannot leave by diffusion. Chloroquine caps hemozoin molecules to prevent further polymerisation of heme. Thus leading to heme build up. Chloroquine binds to heme (or FP) to form what is known as the FP-Chloroquine complex, this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-Chloroquine and FP results in cell lysis and ultimatly parasite cell autodigestion. Basically the parasite cell drowns in its own metabolic products.
+{{Japan Squad 2006 World Cup}}
+{{West Bromwich Albion F.C. Squad}}
+[[Category:1979 births|Inamoto Junichi]]
-The effectiveness of chloroquine against the parasite has declined as some resistant forms of the parasite can effectively neutralize the drug by developing a mechanism that drains chloroquine away from the digestive vacuole. CQ-Resistant cells efflux chloroquine at 40 times the rate of CQ-Sensitive cells, this is related to a number of mutations that trace back to transmembrane proteins of the digestive vacuole, including an essential mutation in the PfCRT gene (Plasmodium falciparum Chloroquine Resistance Transporter). This mutated protein may actively pump chloroquine from the cell. Resistant parasites frequently have mutated products or amplified expression of [[ABC transporters]] that pump out the chloroquine, typically PfMDR1 and PfMDR2 (Plasmodium falciparum Multi-Drug Resistance genes).
+[[Category:Living people|Inamoto Junichi]]
+[[Category:Japanese footballers|Inamoto Junichi]]
+[[Category:Olympic footballers of Japan|Inamoto, Junichi]]
+[[Category:Footballers at the 2000 Summer Olympics|Inamoto, Junichi]]
+[[Category:Gamba Osaka players|Inamoto, Junichi]]
+[[Category:FA Premier League players|Inamoto, Junichi]]
+[[Category:Arsenal F.C. players|Inamoto, Junichi]]
+[[Category:Fulham F.C. players|Inamoto, Junichi]]
+[[Category:West Bromwich Albion F.C. players|Inamoto, Junichi]]
+[[Category:Cardiff City F.C. players|Inamoto, Junichi]]
+[[Category:FIFA World Cup 2002 players|Inamoto, Junichi]]
+[[Category:FIFA World Cup 2006 players|Inamoto, Junichi]]
+[[Category:FIFA World Cup goalscorers|Inamoto, Junichi]]
+[[de:Junichi Inamoto]]
-Research on the mechanism of chloroquine and how the parasite has acquired chloroquine resistance is still ongoing, and this article is not by any means fact.  Other theories of chloroquine's mechanism of action suggest DNA intercalation or a combination of the disrupted membrane function of the lysosome or the parasite's inability to polymerise heme after chloroquine complexation.
+[[fr:Junichi Inamoto]]
+[[ko:이나모토 준이치]]
-Against rheumatoid arthritis, it operates by inhibiting [[lymphocyte]] proliferation, [[phospholipase|phospholipase A]], release of [[enzyme]]s from [[lysosome]]s, release of [[reactive oxygen species]] from [[macrophage]]s, and production of [[IL-1]].
+[[ja:稲本潤一]]
+[[zh:稻本润一]]
-==Notes==
-<references/>
-[[Category:Antimalarial agents]]
-[[de:Chloroquin]]
-[[ja:クロロキン]]