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Add: s2cid, author pars. 1-1. Removed parameters. Some additions/deletions were actually parameter name changes. | You can use this bot yourself. Report bugs here. | Suggested by Abductive | Category:Genes on human chromosome 11 | via #UCB_Category
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{{Infobox_gene}}
{{Infobox_gene}}
'''Thyroid hormone-inducible hepatic protein''' is a [[protein]] that in humans is encoded by the ''THRSP'' [[gene]].<ref name="pmid9003802">{{cite journal |vauthors=Grillasca JP, Gastaldi M, Khiri H, Dace A, Peyrol N, Reynier P, Torresani J, Planells R | title = Cloning and initial characterization of human and mouse Spot 14 genes | journal = FEBS Lett | volume = 401 | issue = 1 | pages = 38–42 |date=Feb 1997 | pmid = 9003802 | pmc = | doi =10.1016/S0014-5793(96)01433-0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: THRSP thyroid hormone responsive (SPOT14 homolog, rat)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7069| accessdate = }}</ref>
'''Thyroid hormone-inducible hepatic protein''' is a [[protein]] that in humans is encoded by the ''THRSP'' [[gene]].<ref name="pmid9003802">{{cite journal |vauthors=Grillasca JP, Gastaldi M, Khiri H, Dace A, Peyrol N, Reynier P, Torresani J, Planells R | title = Cloning and initial characterization of human and mouse Spot 14 genes | journal = FEBS Lett | volume = 401 | issue = 1 | pages = 38–42 |date=Feb 1997 | pmid = 9003802 | pmc = | doi =10.1016/S0014-5793(96)01433-0 | s2cid = 44575293 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: THRSP thyroid hormone responsive (SPOT14 homolog, rat)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7069| accessdate = }}</ref>


The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to [[liver]] and [[adipose tissue]] and is controlled by nutritional and hormonal factors.
The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to [[liver]] and [[adipose tissue]] and is controlled by nutritional and hormonal factors.
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This gene has been shown to be expressed in liver and [[adipocyte]]s, particularly in [[lipoma]]tous modules. It is also found to be expressed in lipogenic [[breast cancer]]s, which suggests a role in controlling tumor [[lipid metabolism]].<ref name="entrez" />
This gene has been shown to be expressed in liver and [[adipocyte]]s, particularly in [[lipoma]]tous modules. It is also found to be expressed in lipogenic [[breast cancer]]s, which suggests a role in controlling tumor [[lipid metabolism]].<ref name="entrez" />


Previously, THRSP was among the identified upregulated genes in the prefrontal cortex of spontaneously hypertensive rats (SHR/NCrl) and Wistar-Kyoto (WKY/NCrl) rats which exhibited inattention behavior.<ref>{{Cite journal|last=dela Peña|first=Ike|last2=Bang|first2=Minji|last3=Lee|first3=Jinhee|last4=de la Peña|first4=June Bryan|last5=Kim|first5=Bung-Nyun|last6=Han|first6=Doug Hyun|last7=Noh|first7=Minsoo|last8=Shin|first8=Chan Young|last9=Cheong|first9=Jae Hoon|date=September 2015|title=Common prefrontal cortical gene expression profiles between adolescent SHR/NCrl and WKY/NCrl rats which showed inattention behavior|journal=Behavioural Brain Research|language=en|volume=291|pages=268–276|doi=10.1016/j.bbr.2015.05.012|pmid=26048425}}</ref> Subsequently, overexpression of THRSP induced inattention, but not hyperactive and impulsive behavior in mice, suggesting that this gene plays a role in the inattention phenotype of ADHD.<ref>{{Cite journal|last=Custodio|first=Raly James Perez|last2=Botanas|first2=Chrislean Jun|last3=de la Peña|first3=June Bryan|last4=dela Peña|first4=Irene Joy|last5=Kim|first5=Mikyung|last6=Sayson|first6=Leandro Val|last7=Abiero|first7=Arvie|last8=Ryoo|first8=Zae Young|last9=Kim|first9=Bung-Nyun|last10=Kim|first10=Hee Jin|last11=Cheong|first11=Jae Hoon|date=October 2018|title=Overexpression of the Thyroid Hormone-Responsive (THRSP) Gene in the Striatum Leads to the Development of Inattentive-like Phenotype in Mice|journal=Neuroscience|language=en|volume=390|pages=141–150|doi=10.1016/j.neuroscience.2018.08.008|pmid=30138648}}</ref>
Previously, THRSP was among the identified upregulated genes in the prefrontal cortex of spontaneously hypertensive rats (SHR/NCrl) and Wistar-Kyoto (WKY/NCrl) rats which exhibited inattention behavior.<ref>{{Cite journal|last1=dela Peña|first1=Ike|last2=Bang|first2=Minji|last3=Lee|first3=Jinhee|last4=de la Peña|first4=June Bryan|last5=Kim|first5=Bung-Nyun|last6=Han|first6=Doug Hyun|last7=Noh|first7=Minsoo|last8=Shin|first8=Chan Young|last9=Cheong|first9=Jae Hoon|date=September 2015|title=Common prefrontal cortical gene expression profiles between adolescent SHR/NCrl and WKY/NCrl rats which showed inattention behavior|journal=Behavioural Brain Research|language=en|volume=291|pages=268–276|doi=10.1016/j.bbr.2015.05.012|pmid=26048425|s2cid=9853684}}</ref> Subsequently, overexpression of THRSP induced inattention, but not hyperactive and impulsive behavior in mice, suggesting that this gene plays a role in the inattention phenotype of ADHD.<ref>{{Cite journal|last1=Custodio|first1=Raly James Perez|last2=Botanas|first2=Chrislean Jun|last3=de la Peña|first3=June Bryan|last4=dela Peña|first4=Irene Joy|last5=Kim|first5=Mikyung|last6=Sayson|first6=Leandro Val|last7=Abiero|first7=Arvie|last8=Ryoo|first8=Zae Young|last9=Kim|first9=Bung-Nyun|last10=Kim|first10=Hee Jin|last11=Cheong|first11=Jae Hoon|date=October 2018|title=Overexpression of the Thyroid Hormone-Responsive (THRSP) Gene in the Striatum Leads to the Development of Inattentive-like Phenotype in Mice|journal=Neuroscience|language=en|volume=390|pages=141–150|doi=10.1016/j.neuroscience.2018.08.008|pmid=30138648|s2cid=52075574}}</ref>


==References==
==References==
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{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal |vauthors=Cunningham BA, Moncur JT, Huntington JT, Kinlaw WB |title="Spot 14" protein: a metabolic integrator in normal and neoplastic cells. |journal=Thyroid |volume=8 |issue= 9 |pages= 815–25 |year= 1998 |pmid= 9777755 |doi=10.1089/thy.1998.8.815 }}
*{{cite journal |vauthors=Cunningham BA, Moncur JT, Huntington JT, Kinlaw WB |title="Spot 14" protein: a metabolic integrator in normal and neoplastic cells. |journal=Thyroid |volume=8 |issue= 9 |pages= 815–25 |year= 1998 |pmid= 9777755 |doi=10.1089/thy.1998.8.815 }}
*{{cite journal |vauthors=Ota Y, Mariash A, Wagner JL, Mariash CN |title=Cloning, expression and regulation of the human S14 gene. |journal=Mol. Cell. Endocrinol. |volume=126 |issue= 1 |pages= 75–81 |year= 1997 |pmid= 9027365 |doi=10.1016/S0303-7207(96)03971-8 }}
*{{cite journal |vauthors=Ota Y, Mariash A, Wagner JL, Mariash CN |title=Cloning, expression and regulation of the human S14 gene. |journal=Mol. Cell. Endocrinol. |volume=126 |issue= 1 |pages= 75–81 |year= 1997 |pmid= 9027365 |doi=10.1016/S0303-7207(96)03971-8 |s2cid=22056127 }}
*{{cite journal | author=Taviaux S |title=Assignment of thyroid hormone responsive SPOT 14 homolog (THRSP) to human chromosome 11 bands q13.5→q14.1 by in situ hybridization |journal=Cytogenet. Cell Genet. |volume=76 |issue= 3–4 |pages= 219–20 |year= 1997 |pmid= 9186528 |doi=10.1159/000134553 |name-list-format=vanc| author2=Planells R | author3=Gastaldi M | display-authors=3 | last4=Torresani | first4=J. | last5=Grillasca | first5=J.P. }}
*{{cite journal | author=Taviaux S |title=Assignment of thyroid hormone responsive SPOT 14 homolog (THRSP) to human chromosome 11 bands q13.5→q14.1 by in situ hybridization |journal=Cytogenet. Cell Genet. |volume=76 |issue= 3–4 |pages= 219–20 |year= 1997 |pmid= 9186528 |doi=10.1159/000134553 |name-list-format=vanc| author2=Planells R | author3=Gastaldi M | display-authors=3 | last4=Torresani | first4=J. | last5=Grillasca | first5=J.P. }}
*{{cite journal | author=Moncur JT |title=Assignment of the "spot 14" gene (THRSP) to human chromosome band 11q13.5 by in situ hybridization |journal=Cytogenet. Cell Genet. |volume=78 |issue= 2 |pages= 131–2 |year= 1997 |pmid= 9371405 |doi=10.1159/000134644 |name-list-format=vanc| author2=Park JP | author3=Maloney M | display-authors=3 | last4=Mohandas | first4=T.K. | last5=Kinlaw | first5=W.B. }}
*{{cite journal | author=Moncur JT |title=Assignment of the "spot 14" gene (THRSP) to human chromosome band 11q13.5 by in situ hybridization |journal=Cytogenet. Cell Genet. |volume=78 |issue= 2 |pages= 131–2 |year= 1997 |pmid= 9371405 |doi=10.1159/000134644 |name-list-format=vanc| author2=Park JP | author3=Maloney M | display-authors=3 | last4=Mohandas | first4=T.K. | last5=Kinlaw | first5=W.B. }}
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*{{cite journal |vauthors=Campbell MC, Anderson GW, Mariash CN |title=Human spot 14 glucose and thyroid hormone response: characterization and thyroid hormone response element identification |journal=Endocrinology |volume=144 |issue= 12 |pages= 5242–8 |year= 2004 |pmid= 12960053 |doi= 10.1210/en.2002-0008 |doi-access= free }}
*{{cite journal |vauthors=Campbell MC, Anderson GW, Mariash CN |title=Human spot 14 glucose and thyroid hormone response: characterization and thyroid hormone response element identification |journal=Endocrinology |volume=144 |issue= 12 |pages= 5242–8 |year= 2004 |pmid= 12960053 |doi= 10.1210/en.2002-0008 |doi-access= free }}
*{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
*{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
*{{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija |bibcode=2005Natur.437.1173R }}
*{{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
*{{cite journal | author=Chou WY |title=Human spot 14 protein interacts physically and functionally with the thyroid receptor |journal=Biochem. Biophys. Res. Commun. |volume=357 |issue= 1 |pages= 133–8 |year= 2007 |pmid= 17418816 |doi= 10.1016/j.bbrc.2007.03.103 |name-list-format=vanc| author2=Cheng YS | author3=Ho CL | display-authors=3 | last4=Liu | first4=Shu-Ting | last5=Liu | first5=Pei-Yao | last6=Kuo | first6=Chen-Chin | last7=Chang | first7=Hui-Ping | last8=Chen | first8=Yu-Hou | last9=Chang | first9=Gu-Gang }}
*{{cite journal | author=Chou WY |title=Human spot 14 protein interacts physically and functionally with the thyroid receptor |journal=Biochem. Biophys. Res. Commun. |volume=357 |issue= 1 |pages= 133–8 |year= 2007 |pmid= 17418816 |doi= 10.1016/j.bbrc.2007.03.103 |name-list-format=vanc| author2=Cheng YS | author3=Ho CL | display-authors=3 | last4=Liu | first4=Shu-Ting | last5=Liu | first5=Pei-Yao | last6=Kuo | first6=Chen-Chin | last7=Chang | first7=Hui-Ping | last8=Chen | first8=Yu-Hou | last9=Chang | first9=Gu-Gang }}
{{refend}}
{{refend}}

Revision as of 10:14, 11 October 2020

THRSP
Identifiers
AliasesTHRSP, LPGP1, Lpgp, S14, SPOT14, THRP, thyroid hormone responsive
External IDsOMIM: 601926; MGI: 109126; HomoloGene: 2441; GeneCards: THRSP; OMA:THRSP - orthologs
Orthologs
SpeciesHumanMouse
Entrez

7069

21835

Ensembl

ENSG00000151365

ENSMUSG00000035686

UniProt

Q92748

Q62264

RefSeq (mRNA)

NM_003251

NM_009381

RefSeq (protein)

NP_003242

NP_033407

Location (UCSC)Chr 11: 78.06 – 78.07 MbChr 7: 97.06 – 97.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thyroid hormone-inducible hepatic protein is a protein that in humans is encoded by the THRSP gene.[5][6]

The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors.

This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism.[6]

Previously, THRSP was among the identified upregulated genes in the prefrontal cortex of spontaneously hypertensive rats (SHR/NCrl) and Wistar-Kyoto (WKY/NCrl) rats which exhibited inattention behavior.[7] Subsequently, overexpression of THRSP induced inattention, but not hyperactive and impulsive behavior in mice, suggesting that this gene plays a role in the inattention phenotype of ADHD.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151365 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035686 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Grillasca JP, Gastaldi M, Khiri H, Dace A, Peyrol N, Reynier P, Torresani J, Planells R (Feb 1997). "Cloning and initial characterization of human and mouse Spot 14 genes". FEBS Lett. 401 (1): 38–42. doi:10.1016/S0014-5793(96)01433-0. PMID 9003802. S2CID 44575293.
  6. ^ a b "Entrez Gene: THRSP thyroid hormone responsive (SPOT14 homolog, rat)".
  7. ^ dela Peña, Ike; Bang, Minji; Lee, Jinhee; de la Peña, June Bryan; Kim, Bung-Nyun; Han, Doug Hyun; Noh, Minsoo; Shin, Chan Young; Cheong, Jae Hoon (September 2015). "Common prefrontal cortical gene expression profiles between adolescent SHR/NCrl and WKY/NCrl rats which showed inattention behavior". Behavioural Brain Research. 291: 268–276. doi:10.1016/j.bbr.2015.05.012. PMID 26048425. S2CID 9853684.
  8. ^ Custodio, Raly James Perez; Botanas, Chrislean Jun; de la Peña, June Bryan; dela Peña, Irene Joy; Kim, Mikyung; Sayson, Leandro Val; Abiero, Arvie; Ryoo, Zae Young; Kim, Bung-Nyun; Kim, Hee Jin; Cheong, Jae Hoon (October 2018). "Overexpression of the Thyroid Hormone-Responsive (THRSP) Gene in the Striatum Leads to the Development of Inattentive-like Phenotype in Mice". Neuroscience. 390: 141–150. doi:10.1016/j.neuroscience.2018.08.008. PMID 30138648. S2CID 52075574.

Further reading


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