Alison Goate
Alison Goate | |
---|---|
Citizenship | British |
Education | Oxford University (DPhil 1983) |
Known for | Alzheimer's disease, addiction |
Awards | Potamkin Prize (1993) Metlife Foundation Award (1994) Alzheimer's Association Lifetime Achievement Award (2015) Rainwater Prize(2022) Piepenbrock-DZNE Prize (2023) |
Scientific career | |
Fields | Neurology, Genetics |
Institutions | Icahn School of Medicine Washington University in St. Louis |
Alison Mary Goate is the Jean C. and James W. Crystal Professor and Chair of the Department of Genetics and Genomic Sciences and Director of the Loeb Center for Alzheimer's Disease at Icahn School of Medicine at Mount Sinai, New York City.[1][2] She was previously professor of genetics in psychiatry, professor of genetics, and professor of neurology at Washington University School of Medicine.[3]
The Goate Lab studies the genetics and molecular bases of Alzheimer's disease, frontotemporal dementia, and alcoholism.[4]
Education and early career
After receiving her undergraduate degree in biochemistry at the University of Bristol (UK) and her graduate training at Oxford University (UK), Goate studied under Professors Theodore Puck, Professor Louis Lim and Dr. John Hardy. She received a Royal Society University Research Fellowship to conduct research at St. Mary's Hospital Medical School in London.[5]
Awards and affiliations
She has received the Potamkin Prize from the American Academy of Neurology (1993), the Zenith Award from the Alzheimer's Association, Senior Investigator Award from the Metropolitan Life Foundation, the St. Louis Academy of Science Innovation Award, Carl and Gerty Cori Faculty Achievement Award at Washington University in St. Louis. (1994), and a Lifetime Achievement Award from the Alzheimer's Association (2015).[6] She is a fellow of the American Association for the Advancement of Science.[1] She also serves on the faculty of the Hope Center for Neurological Disorders[7] and is an elected member of the National Academy of Medicine.[8] Dr. Goate received the Rainwater Prize for Innovation in Neurodegeneration from the Rainwater Charitable Foundation in 2022. [9] Dr. Goate was the first female to be awarded the Piepenbrock-DZNE Prize for Neurodegenerative disease research in 2023. [10]
Research
Goate's research centers on the genetics of Alzheimer's disease and related dementias that led to the development of animal and cellular models and the development of anti-amyloid and anti-tau therapies. She has been the principal investigator on four grants and has co-invented and awarded six patents.
Patents
- APP770 mutant in alzheimer's disease, (1999).[11]
- Mutant S182 genes, (1999).[12]
- Method for elucidation and detection of polymorphisms, splice variants, and proximal coding mutations using intronic sequences of the Alzheimer's S182 gene, (2000).[13]
- Transgenic mouse expressing an APP-FAD DNA sequence, (2001).[14]
- Pathogenic Tau mutations, (2002).[15]
- Markers for addiction, (2011).[16]
Grants
Partial list:[17]
Funding Source, Project Title & Number | Role in Project | Dates | Direct Costs |
---|---|---|---|
NIH/NIA/Columbia University
National Institute on Aging Alzheimer's Disease Family-Based Study (NIA-AD FBS) U24AG056270[18] |
Subaward PI (MPI) | 8/1/2022 - 4/30/2027 | $151,653 |
NIH/NIA
Neuroprotective Signaling and Transcriptional Pathways in Microglia Associated with Alzheimer’s Disease R01AG072489[19] |
MPI | 2/1/2022 - 11/30/2026 | $5,972,363 |
NIH/NINDS
Uncovering the Genetic Mechanisms of the Chromosome 17q21.31 Tau haplotype on Neurodegeneration Risk in FTD and PSP U54NS123746[20] |
MPI | 9/1/2021 - 8/31/2026 | $9,278,441 |
The JPB Foundation
Integrative approaches to the identification of AD risk genes and novel therapeutics 2023-4265 |
Principal Investigator | 9/1/2023 - 8/31/2026 | $2,250,000 |
NIH/NIA/Mayo Clinic
Biology and Pathobiology of ApoE in Aging and Alzheimer’s Disease U19AG069701[21] |
Subaward PI (MPI) | 6/1/2021 - 5/31/2026 | $1,885,527 |
Cure Alzheimer's Foundation
Investigating MEF2C transcription factor as therapeutic targets to reprogram pathological microglial states in Alzheimer's disease[22] |
Principal Investigator | 1/14/2024 - 1/13/2026 | $201,250 |
Rainwater Charitable Foundation
Using unbiased proteomics to validate iPSC models of FTD-MAPT and discover novel biomarkers |
MPI | 8/1/2023 - 7/31/2025 | $200,000 |
NIH/NIA/Massachusetts Institute of Technology
Development of PU.1 Inhibitory Modulators as Novel Therapeutics for Alzheimer’s Disease U01AG066757[23] |
Subaward PI (MPI) | 5/15/2020 - 4/30/2025 | $1,364,375 |
NIH/NIA/Banner Health
APOE in the Predisposition to, Protection from and Prevention of Alzheimer’s Disease R01AG069453[24] |
Subaward PI (MPI) | 7/1/2020 - 3/31/2025 | $71,390 |
NIH/NIA/University of Pennsylvania
Alzheimer’s Disease Genetics Consortium U01AG032984[25] |
Subaward PI | 3/6/2020 - 8/31/2024 | $1,021,752 |
NIH/NINDS/University of Miami
Reducing Disparities in Dementia and VCID Outcomes in a Multicultural Rural Population[26] R01NS101483 |
Subaward PI | 4/15/2020 - 3/31/2025 | $78,593 |
NIH/NIAAA/SUNY
Collaborative Study on the Genetics of Alcoholism (COGA) U10AA008401[27] |
Subaward PI | 9/1/2019 - 8/31/2024 | $2,175,426 |
M.D. Anderson
Understanding the mechanism of MS4A-dependent AD risk AGR-13139 |
Principal Investigator | 8/7/2017 - 8/31/2024 | $3,562,500 |
NIH/NIA
Genomic Approach to Identification of Microglial Networks Involved in Alzheimer’s Disease Risk U01AG058635[28] |
Principal Investigator | 8/1/2018 - 7/31/2024 | $4,799,685 |
NIH/NIA/Washington University
DIAN Genetics Core U19AG032438[29] |
Subaward PI and Core Leader | 7/1/2019 - 6/30/2024 | $651,291 |
Rainwater Charitable Foundation
Investigating rare and common mechanisms underlying tauopathy risk |
Principal Investigator | 11/1/2022 - 4/30/2024 | $230,000 |
Publications
Semantic Scholar lists 483 publications, 22,943 citations and 1,808 influential citations of Goate's peer-reviewed and original contribution as of 2019.[30]
Partial list:
- Goate, A.; et al. (1991). "Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease". Nature. 349 (6311): 704–706. Bibcode:1991Natur.349..704G. doi:10.1038/349704a0. PMID 1671712. S2CID 4336069. Cited by 5017 as of October 18, 2019.[31]
- De Strooper, B.; et al. (1999). "A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain". Nature. 398 (6727): 518–22. Bibcode:1999Natur.398..518D. doi:10.1038/19083. PMID 10206645. S2CID 4346474. Cited by 2274 as of October 18, 2019.[31]
- Saccone, S. F.; et al. (2007). "Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPS". Human Molecular Genetics. 16 (1): 36–49. doi:10.1093/hmg/ddl438. PMC 2270437. PMID 17135278. Cited by 793 as of October 18, 2019[31]
- Bierut, L. J.; et al. (2007). "Novel genes identified in a high-density genome wide association study for nicotine dependence". Human Molecular Genetics. 16 (1): 24–35. doi:10.1093/hmg/ddl441. PMC 2278047. PMID 17158188. Cited by 604 as of October 18, 2019.[31]
- Kehoe, P.; et al. (1999). "A full genome scan for late onset Alzheimer's disease". Human Molecular Genetics. 8 (2): 237–45. doi:10.1093/hmg/8.2.237. PMID 9931331. Cited by 419 as of October 18, 2019[31]
- Foroud, T.; et al. (2000). "Alcoholism susceptibility loci: Confirmation studies in a replicate sample and further mapping". Alcoholism: Clinical and Experimental Research. 24 (7): 933–45. doi:10.1111/j.1530-0277.2000.tb04634.x. PMID 10923994. Cited by 275 as of October 18, 2019.[31]
[32]==References==
- ^ a b "Alison M Goate". Icahn School of Medicine at Mount Sinai. Archived from the original on 23 October 2018. Retrieved 23 October 2018.
- ^ "Huffington Center on Aging celebrates 30th anniversary". BCM Family. 5 November 2018. Archived from the original on 18 October 2019. Retrieved 18 October 2019.
- ^ Goate, Alison (2008). "Interview". Biomarkers in Medicine. 2 (6). Future Medicine Ltd: 541–545. doi:10.2217/17520363.2.6.541. ISSN 1752-0363. PMID 20477443.
- ^ Icahn School of Medicine at Mount Sinai. "Goate Lab". Icahn School of Medicine at Mount Sinai. Archived from the original on 2 September 2019. Retrieved 26 August 2019.
- ^ Goate, Alison (December 2008). "Interview". Biomarkers in Medicine. 2 (6): 541–545. doi:10.2217/17520363.2.6.541. PMID 20477443. Archived from the original on 19 October 2019. Retrieved 19 October 2019.
- ^ Goate, Alison (2 December 2008). "Interview with Alison Goate". Biomarkers in Medicine. 2 (6): 541–545. doi:10.2217/17520363.2.6.541. ISSN 1752-0371. PMID 20477443.
- ^ "Announcements: Bob Lane Receives Lifetime Achievement Award". 1998. doi:10.1037/e404572005-032.
{{cite journal}}
: Cite journal requires|journal=
(help) - ^ "National Academy of Medicine Elects 80 New Members". National Academy of Medicine. 17 October 2016. Archived from the original on 6 January 2017. Retrieved 18 October 2019.
- ^ "RCF Announces Third-Annual Rainwater Prize Winners for Neurodegenerative Research". 14 December 2021.
- ^ "Award for Dementia Researcher from New York City".
- ^ US 5877015, Hardy, John Anthony; Chartier-Harlin, Marie-Christine & Goate, Alison Mary et al., "APP770 mutant in Alzheimer's disease", published 1999-03-02, assigned to Imperial College of Science, Technology and Medicine
- ^ US 5973133, Hardy, John A. & Goate, Alison M., "Mutant S182 genes", published 1999-10-26, assigned to Washington University and University of South Florida
- ^ US 6083694, Hardy, John & Goate, Alison M., "Method for elucidation and detection of polymorphisms, splice variants, and proximal coding mutations using intronic sequences of the Alzheimer's S182 gene", published 2000-07-04, assigned to Washington University and University of South Florida
- ^ US 6300540, Hardy, John Anthony; Chartier-Harlin, Marie-Christine & Goate, Alison Mary et al., "Transgenic mouse expressing an APP-FAD DNA sequence", published 2001-10-09, assigned to Elan Pharmaceuticals Inc.
- ^ "Espacenet – search results". worldwide.espacenet.com. Archived from the original on 16 March 2023. Retrieved 16 March 2023.
- ^ US 8080371, Ballinger, Dennis; Konvicka, Karel & Bierut, Laura Jean et al., "Markers for addiction", published 2011-12-20, assigned to Washington University in St. Louis
- ^ "Alison M. Goate, PhD - US grants". Neurotree. Archived from the original on 16 March 2023. Retrieved 15 September 2019.
- ^ https://reporter.nih.gov/search/Dnc0OPFt_EW6NYGMIc5N_w/project-details/10840010.
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(help) - ^ https://reporter.nih.gov/search/whVj7vgJPEyke0E_Vxg6gA/project-details/10902613.
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(help) - ^ https://reporter.nih.gov/search/DfqcG02fEUaFjGBdcWLJlA/project-details/10407934.
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(help) - ^ https://curealz.org/research/translational/studies-of-innate-immune-pathology/investigating-mef2c-transcription-factor-as-a-therapeutic-target-to-reprogram-pathological-microglial-states-in-alzheimers-disease/.
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(help) - ^ https://reporter.nih.gov/search/wUQEfU9jq0KooC8qY0YGNw/project-details/10853048.
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(help) - ^ https://reporter.nih.gov/search/r6N-9CLc2U--kjh7jaoj5A/project-details/10137858.
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(help) - ^ https://reporter.nih.gov/search/lx4NNGE-EkWS8JmcRR0cvA/project-details/10612832.
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(help) - ^ https://reporter.nih.gov/search/cTdGgGBhkkWyOArUML5JWQ/project-details/10690729.
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(help) - ^ https://reporter.nih.gov/search/979QVkW5aUC7wp2nMdne9A/project-details/10468712.
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(help) - ^ https://reporter.nih.gov/search/3FSlmW_3PkuGfyiqFuTugA/project-details/10665737.
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(help) - ^ "Alison M. Goate - Semantic Scholar". www.semanticscholar.org. Archived from the original on 18 October 2019. Retrieved 18 October 2019.
- ^ a b c d e f "Google Scholar". scholar.google.com. Archived from the original on 16 March 2023. Retrieved 18 October 2019.
- ^ Machlovi, Saima (2021). "APOE4 confers transcriptomic and functional alterations to primary mouse microglia". Journal of Neuroscience Research. 99 (1): 9–12. doi:10.1002/jnr.24570. PMC 7754118. PMID 32267025.
- Living people
- 20th-century British biologists
- 20th-century British women scientists
- 21st-century British biologists
- 21st-century British women scientists
- Academics of the University of Oxford
- Alumni of the University of Bristol
- Alumni of the University of Oxford
- Alzheimer's disease researchers
- British geneticists
- British neuroscientists
- British women neuroscientists
- Fellows of the American Association for the Advancement of Science
- Icahn School of Medicine at Mount Sinai faculty
- Members of the National Academy of Medicine
- Psychiatric geneticists
- Washington University School of Medicine faculty