3-hydroxypimeloyl-CoA dehydrogenase

In enzymology, a 3-hydroxypimeloyl-CoA dehydrogenase (EC 1.1.1.259) is an enzyme that catalyzes the chemical reaction

3-hydroxypimeloyl-CoA + NAD⁺ $\rightleftharpoons$ 3-oxopimeloyl-CoA + NADH + H⁺

Thus, the two substrates of this enzyme are 3-hydroxypimeloyl-CoA and NAD⁺, whereas its 3 products are 3-oxopimeloyl-CoA, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-hydroxypimeloyl-CoA:NAD+ oxidoreductase. This enzyme participates in benzoate degradation via coa ligation.

References

• Harwood CS, Gibson J (1997). "Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?". J. Bacteriol. 179: 301–9. PMID 8990279.