Binder's syndrome

Binder's Syndrome (Maxillo-Nasal Dysplasia) is a developmental disorder primarily affecting the anterior part of the maxilla and nasal complex (nose and jaw). It is a rare disorder and the causes are unclear. Hereditary and vitamin d deficiency during embryonic growth have been researched as possible causes.

The characteristics of the syndrome are typically visible. Affected individuals typically have an unusually flat, underdeveloped midface (midfacial hypoplasia), with an abnormally short nose and flat nasal bridge, underdeveloped upper jaw, relatively protruding lower jaw and/or a 'reverse overbite' (or class III malocclusion). Many who have a severity of the disorder undergo plastic surgery or orthodontic treatment for cosmetic reasons.

References

• F. Cuilliera, F. Cartaultb, P. Lemaired, J.L. Alessandric. "Maxillo-Nasal Dysplasia (Binder Syndrome): Antenatal Discovery and Implications", Fetal Diagnosis and Therapy, 2005.
• P. K. Nedev : The Binder Syndrome: Review Of The Literature And Case Report . The Internet Journal of Neurosurgery. 2008 Volume 5 Number 1

Larkin04 (talk) 05:03, 12 April 2009 (UTC)