ICP8
ICP8, the herpes simplex virus type-1 single-strand DNA-binding protein, is one of seven proteins encoded in the viral genome of HSV-1 that is required for HSV-1 DNA replication.[1] It is able to anneal to ssDNA as well as melt small fragments of dsDNA;[2] its role is to destabilize duplex DNA during initiation of replication. It differs from helicases because it is ATP- and Mg2+-independent.[3] In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8.
ICP8 is required in late gene transcription, and has found to be associated with cellular RNA Polymerase II Holoenzyme.[4]
References
- ^ . PMID 8380461.
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{{cite journal}}: Cite journal requires|journal=(help); Missing or empty|title=(help) - ^ . doi:10.1128/JVI.76.12.5893-5904.2002.
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