Pappalysin-1
| Pappalysin-1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.24.79 | ||||||||
| CAS no. | 151662-33-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Pappalysin-1 (EC 3.4.24.79, insulin-like growth factor binding protein-4 protease, pregnancy-associated plasma protein-A) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction
- Cleavage of the Met135-Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143-Lys bond in IGFBP-5
This enzyme belongs to the peptidase family M43.
See also
References
- ^ Lawrence, J.B., Oxvig, C., Overgaard, M.T., Sottrup-Jensen, L., Gleich, G.J. (1999). ", Hays L.G., Yates, J.R. 3rd, and Conover, C.A. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A". Proc. Natl. Acad. Sci. USA. 96: 3149–3153. doi:10.1073/pnas.96.6.3149. PMC 15910. PMID 10077652.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Chen, B.K., Overgaard, M.T., Bale, L.K., Resch, Z.T., Christiansen, M., Oxvig, C. and Conover, C.A. (2002). "Molecular regulation of the IGF-binding protein-4 protease system in human fibroblasts: identification of a novel inducible inhibitor". Endocrinology. 143: 1199–1205. PMID 11897673.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
External links
- Pappalysin-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)