Chuen Yan Cheng
 | This article needs to be updated. (July 2014) |
Prof Chuen Yan Cheng | |
|---|---|
| Born | June 18, 1954 |
| Nationality | Chinese-American |
| Alma mater | Chinese University of Hong Kong (B.Sc.))
University of Newcastle, Australia (Ph.D.) |
| Known for | Male contraceptive drug |
| Awards | Richard E. Weizman Memorial Award Best Scientific Paper Award |
| Scientific career | |
| Fields | Biotechnology |
| Institutions | Rockefeller University |
Chuen Yan Cheng is the inventor of a male contraceptive drug called Adjudin,[1][2][3][4] which is the first male contraceptive drug shown to be effective in inducing germ cell adhesion in the seminiferous epithelium, causing germ cell depletion from the testis, leading to infertility [5]. Since the population of undifferentiated spermatogonia and spermatogonial stem cells in the testis following adjudin treatment is not affected [6], the adjudin-induced infertility is transient and its anti-fertility effect is reversible. Recently finished animal studies showing no side-effects.[7][8] However, the margin between its efficacy and toxicity following 29-day use in laboratory rats based on a recently completed subchronic toxicity test is narrow [9]. Studies in the laboratory have shown that an endogenously produced biologically active peptide in the testis known as F5-peptide [10] can effectively and transiently break-down the blood-testis barrier. These findings thus illustrate that this F5-peptide can be used in conjunction with adjudin as a multi-drug for male contraception. Recent studies have demonstrated other potential health benefits of adjudin including its anticancer [11] anti-inflammatory [12] and anti-ototoxicity [13] activity, illustrating its potential health benefits following long-term use at low doses.
References
- ^ "Obsessed Scientist Finally Throttles 'Em! Non-Paternity Potion". The New York Observer. Retrieved 2008-09-28.
- ^ "Future male "pill" targets testicles". Retrieved 2008-09-28.
- ^ "Male pill - Science Base". Retrieved 2008-09-28.
- ^ "Seed: The Hunt for Male Birth Control". Retrieved 2008-09-28.
- ^ Cheng CY et al. Contraception 72:251-261, 2005; Mruk DD, Silvestrini B, Cheng CY Pharmacol Rev 60:146-180, 2008.
- ^ Mok KW, Mruk DD, Lee WM, Cheng CY. Int J Androl 35:86-101, 2012
- ^ Connor, Steve (2006-10-30). "Trials for alternative male Pill show no side-effects". The Independent. London. Retrieved 2008-09-28.
- ^ "Male Contraceptive Drug in the Works". Retrieved 2008-09-28. [dead link]
- ^ Mruk DD, Wong CH, Silvestrini B, Cheng CY. Nature Med 12:1323-1328, 2006
- ^ Yan HHN, Mruk DD, Wong EWP, Lee WM, Cheng CY. Proc Natl Acad Sci USA 105:8950-8955, 2008; Su L, Mruk DD, Lie PPY, Silvestrini B, Cheng CY. Nat Communs 3:1185, 2012
- ^ (Xie R, Liu Y, Shao J, Yang J, Liu T, Zhang T, Wang B, Mruk DD, Silvestrini B, Cheng CY, Xia W. Biochem Pharmacol 85:345-355, 2013),
- ^ Shao J, Liu T, Xie QR, Zhang T, Yu H, Wang B, Ying W, Mruk DD, Silvestrini B, Cheng CY, Xia W. J Neuroimmunol 254:834-90, 2013,
- ^ Quan Y, Xia L, Shao J, Yin S, Cheng CY, Xia W, Gao WA. Sci Rep 5:8181