Jump to content

Dennis P. Curran

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Jah247 (talk | contribs) at 13:06, 29 October 2015 (→Research areas). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Dennis P. Curran
File:DennisPatrickCurran.jpg
Dennis P. Curran
Born(1953-06-10)June 10, 1953
Easton, Pennsylvania
NationalityUnited States
Known forOrganic synthesis
Radical chemistry
Fluorous chemistry
AwardsChaire Blaise Pascal Award (2006)[1]
Fellow of the American Chemical Society (inaugural class, 2009)[2]
Scientific career
FieldsChemistry
InstitutionsUniversity of Pittsburgh

Dennis P. Curran (born June 10, 1953) is an American organic chemist and a professor of chemistry at University of Pittsburgh known for his research in the fields of organic chemistry, radical chemistry, and fluorous chemistry.

Career and personal life

Curran received his BS degree from Boston College in 1975 and his PhD degree from the University of Rochester in 1979 working under the direction of Andrew S. Kende. After postdoctoral studies with Barry Trost at the University of Wisconsin, he joined the University of Pittsburgh Department of Chemistry as an Assistant Professor in 1981. He became Associate Professor in 1986, Full Professor in 1988, and Distinguished Service Professor in 1995. He was the first recipient of the Bayer Chair of Chemistry in 1996.

Chemistry runs in Curran’s family. His father, William V. Curran is a 60-year member of the American Chemical Society and the inventor of the third-generation cephalosporin antibiotic cefuzonam. His younger brother Kevin M. Curran has won the Technical Achievement Award of the American Chemical Society Division of Organic Chemistry] (2007).[3]

Research areas

Radical chemistry

Curran is known for his pioneering work on organic radicals Radical_(chemistry) and radical cyclizations Radical_cyclization, especially directed towards organic synthesis. Prior to the 1980’s, radicals were neglected because they were thought to be too reactive and too unselective for use in organic synthesis. Curran parlayed cascade reactions Cascade_reaction of radicals (also called tandem reactions or domino reactions) into powerful tools to make natural products. His 1985 total synthesis of hirsutene [4][5], the first of many such syntheses with cascade radical reactions, is today regarded as a classic.[6]

Curran also revitalized atom transfer radical reactions. These reactions are also called Kharasch addition reactions Kharasch_addition (or sometimes Curran-Kharasch reactions). Morris S. Kharasch Morris_S._Kharasch discovered and pioneered halogen atom transfer addition reactions in an initial flowering period in the late 1940’s and 1950’s. About 40 years later, Curran described fast new reactions involving iodine transfer, bromine transfer and functional group transfer, and encompassing radical addition (ATRA), cyclization (ATRC) and annulation. He introduced sunlamps as convenient tools for photo-initiation of ATRA and ATRC reactions. [4] Curran is also a pioneer in stereoselective radical reactions and radical translocation reactions.

Radical reactions are today regarded as powerful tools for synthesis of natural products and other organic molecules. [7] Curran’s work helped to expose many of the features that are now considered hallmarks of organic radical reactions. Synthetic economy is a primary attraction. Protecting groups and activating functional groups are often superfluous (atom economy Atom_economy). In addition, several bonds can be formed simultaneously (step/pot economy). Other features include reliability, predictability, selectivity, functional group tolerance and inertness to water and other protic solvents. A 1991 synthesis of the imporant anti-cancer agent camptothecin Camptothecin illustrates many of these features. The synthesis takes place over six steps centered on a cascade radical reaction that makes three bonds and two rings. There are no protecting groups, no functional group transformations, no reductions and only one oxidation. [8]

Service

Curran has held various positions on the ACS Division of Organic Chemistry hierarchy, culminating as Chair of the Division in 2000. He was an Associate Editor of Organic Reactions from 1991–2001 and Editor of Tetrahedron Letters from 1995–2001. He is a member of Organic Syntheses, Inc and edited Volume 83 in 2006. He was a member of the Executive Committee of the symposium "Gomberg•2000, A Century of Radical Chemistry",[9] and he spearheaded the presentation on June 25, 2000 of an ACS National Chemical Landmark to the University of Michigan for Gomberg’s 1900 discovery of organic free radicals.[10]

Awards and Honors

Curran is an ACS Fellow and has received several local ACS Section Awards. His national ACS Awards are: the Cope Scholar Award,[11] under-35 category (now called early-career category) (1988), the Award for Creativity in Organic Synthesis (2000),[12] the Award for Creative Work in Fluorine Chemistry (2008),[13] and the Ernst Guenther Award in the Chemistry of Natural Products (2014).[14] He won the Dr. Paul Janssen Prize for Creativity in Organic Synthesis in 1998.[15] Curran has a long history of interaction with the French organic chemistry community. His awards from France include a Chaire Blaise Pascal (2006) from the Région Île-de-France, and a Doctorat Honoris Causa (honorary doctoral degree) from the Université Pierre et Marie Curie, Paris (2010).[16]

References

  1. ^ Chaire Blaise Pascal Award
  2. ^ ACS Fellows
  3. ^ ACS Division of Organic Chemistry
  4. ^ Curran, D. P.; Rakiewicz, D. M., “Tandem radical approach to linear condensed cyclopentanoids. Total synthesis of hirsutene” J. Am. Chem. Soc. 1985, 107, 1448-1449. doi 10.1021/ja00291a077
  5. ^ Curran, D. P.; Rakiewicz, D. M., “Radical-initiated polyolefinic cyclizations in linear triquinane synthesis. Model studies and total synthesis of hirsutene” Tetrahedron 1985, 41, 3943-3958. doi 10.1016/S0040-4020(01)97175-3
  6. ^ Nicolaou, K. C.; Sorenson, E. J., Classics in Total Synthesis, VCH: Weinheim, 1995; Ch 23, pp 381-420, “Hirstutene and Capnellene”.
  7. ^ Chatgilialoglu, C.; Studer, A., Encyclopedia of Radicals in Chemistry, Biology and Materials. Wiley: New York, NY, 2012; Vol. 2,“Synthetic applications and strategies”.
  8. ^ Chatgilialoglu, C.; Studer, A., Encyclopedia of Radicals in Chemistry, Biology and Materials. Wiley: New York, NY, 2012; Vol. 2, "Synthetic applications and strategies”.
  9. ^ Gomberg•2000, A Century of Radical Chemistry
  10. ^ Moses Gomberg and the Discovery of Organic Free Radicals
  11. ^ Arthur C. Cope Scholar Awards
  12. ^ ACS Award for Creative Work in Synthetic Organic Chemistry
  13. ^ ACS Award for Creative Work in Fluorine Chemistry
  14. ^ Ernest Guenther Award in the Chemistry of Natural Products
  15. ^ Janssen Pharmaceutica Prize for Creativity in Organic Synthesis
  16. ^ Cérémonie des Docteurs honoris causa 2010

Template:Persondata

Retrieved from "https://en.wikipedia.org/w/index.php?title=Dennis_P._Curran&oldid=688069753"