AGXT

AGXT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H0C, 1J04, 2YOB, 3R9A, 4CBR, 4CBS, 4I8A, 4KXK, 4KYO
Identifiers
Aliases	AGXT, AGT, AGT1, AGXT1, PH1, SPAT, SPT, TLH6, alanine-glyoxylate aminotransferase, alanine--glyoxylate and serine--pyruvate aminotransferase, Ser-PyrAT
External IDs	OMIM: 604285; MGI: 1329033; HomoloGene: 37251; GeneCards: AGXT; OMA:AGXT - orthologs
EC number	2.6.1.44
Gene location (Human)
Chr.	Chromosome 2 (human)
End	240,880,502 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	93,073,143 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; buccal mucosa cell; ; cartilage tissue; ; human kidney; ; testicle; ; kidney tubule; ; cerebellar vermis; ; gonad; ; renal medulla; ; renal cortex;
	Top expressed in
	left lobe of liver; ; embryo; ; gallbladder; ; sexually immature organism; ; gastrula; ; duodenum; ; jejunum; ; Ileal epithelium; ; CA3 field; ; submandibular gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein homodimerization activity; amino acid binding; alanine-glyoxylate transaminase activity; serine-pyruvate transaminase activity; transaminase activity; protein self-association; catalytic activity; protein binding; pyridoxal phosphate binding; signaling receptor binding; identical protein binding;
Cellular component	peroxisome; mitochondrial matrix; peroxisomal matrix; mitochondrion; intracellular membrane-bounded organelle; cytosol;
Biological process	Notch signaling pathway; oxalic acid secretion; glyoxylate catabolic process; glycine biosynthetic process, by transamination of glyoxylate; pyruvate biosynthetic process; L-alanine catabolic process; response to glucocorticoid; response to cAMP; L-cysteine catabolic process; cellular nitrogen compound metabolic process; glyoxylate metabolic process; protein targeting to peroxisome;
	Sources:Amigo / QuickGO
Orthologs
	189
	11611
	ENSG00000172482
	ENSMUSG00000026272
	P21549
	O35423
	NM_000030
	NM_001276710; NM_016702
	NP_000021
	NP_001263639; NP_057911
	Wikidata
View/Edit Human	View/Edit Mouse

Serine—pyruvate aminotransferase is an enzyme that in humans is encoded by the AGXT gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172482 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026272 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nishiyama K, Funai T, Katafuchi R, Hattori F, Onoyama K, Ichiyama A (Jul 1991). "Primary hyperoxaluria type I due to a point mutation of T to C in the coding region of the serine:pyruvate aminotransferase gene". Biochem Biophys Res Commun. 176 (3): 1093–9. doi:10.1016/0006-291X(91)90396-O. PMID 2039493.
^ Purdue PE, Lumb MJ, Fox M, Griffo G, Hamon-Benais C, Povey S, Danpure CJ (Jul 1991). "Characterization and chromosomal mapping of a genomic clone encoding human alanine:glyoxylate aminotransferase". Genomics. 10 (1): 34–42. doi:10.1016/0888-7543(91)90481-S. PMID 2045108.
^ "Entrez Gene: AGXT alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase)".

External links

GeneReviews/NIH/NCBI/UW entry on Primary Hyperoxaluria Type 1
Human AGT genome location and AGT gene details page in the UCSC Genome Browser.
Human AGXT genome location and AGXT gene details page in the UCSC Genome Browser.

v t e Transferase: nitrogenous groups (EC 2.6)
2.6.1: Transaminases	Aspartate transaminase GOT1 GOT2 Alanine transaminase GABA transaminase Tyrosine aminotransferase Kynurenine—oxoglutarate transaminase Ornithine aminotransferase Branched-chain amino acid aminotransferase Alanine—glyoxylate transaminase AGXT
2.6.3: Oximinotransferases	Oximinotransferase
2.6.99: Other	Pyridoxine 5'-phosphate synthase

References

External links

Further reading