CAMSAP3

CAMSAP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UGJ
Identifiers
Aliases	CAMSAP3, KIAA1543, NEZHA, PPP1R80, calmodulin regulated spectrin associated protein family member 3
External IDs	OMIM: 612685; MGI: 1916947; HomoloGene: 18966; GeneCards: CAMSAP3; OMA:CAMSAP3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	7,618,304 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	3,609,075 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; skin of leg; ; mucosa of transverse colon; ; right lobe of liver; ; body of pancreas; ; right hemisphere of cerebellum; ; duodenum; ; right lobe of thyroid gland; ; salivary gland; ; minor salivary glands;
	Top expressed in
	secondary oocyte; ; lip; ; primary oocyte; ; submandibular gland; ; lacrimal gland; ; zygote; ; epiblast; ; duodenum; ; zone of skin; ; epithelium of stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding; spectrin binding; calmodulin binding; protein binding; actin filament binding; microtubule minus-end binding;
Cellular component	cytoplasm; zonula adherens; adherens junction; cell junction; centrosome; microtubule; cytoskeleton; microtubule minus-end;
Biological process	negative regulation of phosphatase activity; regulation of microtubule cytoskeleton organization; microtubule anchoring; epithelial cell-cell adhesion; neuron projection development; zonula adherens maintenance; regulation of cell migration; regulation of focal adhesion assembly; regulation of Golgi organization; microtubule cytoskeleton organization; embryo development ending in birth or egg hatching; establishment or maintenance of microtubule cytoskeleton polarity; regulation of microtubule polymerization; regulation of organelle organization; establishment of epithelial cell apical/basal polarity; protein transport along microtubule; negative regulation of microtubule depolymerization; cytoplasmic microtubule organization;
	Sources:Amigo / QuickGO
Orthologs
	57662
	69697
	ENSG00000076826
	ENSMUSG00000044433
	Q9P1Y5
	Q80VC9
	NM_001080429; NM_020902
	NM_001163749; NM_027171; NM_001347111; NM_001347112; NM_001347113
	NP_001073898; NP_065953
NP_001157221; NP_001334040; NP_001334041; NP_001334042; NP_081447;
	NP_001350168; NP_001350169; NP_001350170; NP_001350171; NP_001350172; NP_001350173; NP_001350174; NP_001350175; NP_001350176; NP_001350177; NP_001350178
	Wikidata
View/Edit Human	View/Edit Mouse

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Calmodulin-regulated spectrin-associated protein family member 3 (CAMSAP3) is a human protein encoded by the gene CAMSAP3. The protein is commonly referred to as Nezha.

Function

CAMSAP3 acts as a minus-end anchor of microtubules, and binds to them through its CKK domain.^[5]

In epithelial cells, it anchors microtubules to the apical cortex, causing them to grow in an apical-to-basal direction.^[6] This gives the epithelial cells their rectangular shape.

In early mouse embryogenesis, the interphase bridge linking sister cells is enriched with CAMSAP3.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000076826 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044433 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Baines, A. J.; Bignone, P. A.; King, M. D.A.; Maggs, A. M.; Bennett, P. M.; Pinder, J. C.; Phillips, G. W. (2009-09-01). "The CKK Domain (DUF1781) Binds Microtubules and Defines the CAMSAP/ssp4 Family of Animal Proteins". Molecular Biology and Evolution. 26 (9): 2005–2014. doi:10.1093/molbev/msp115. ISSN 0737-4038. PMID 19508979. Archived from the original on 2022-06-15. Retrieved 2022-09-29.
^ Toya M, Kobayashi S, Kawasaki M, Shioi G, Kaneko M, Ishiuchi T, et al. (January 2016). "CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells". Proceedings of the National Academy of Sciences of the United States of America. 113 (2): 332–337. Bibcode:2016PNAS..113..332T. doi:10.1073/pnas.1520638113. PMC 4720291. PMID 26715742.
^ Zenker J, White MD, Templin RM, Parton RG, Thorn-Seshold O, Bissiere S, Plachta N (September 2017). "A microtubule-organizing center directing intracellular transport in the early mouse embryo". Science. 357 (6354): 925–928. Bibcode:2017Sci...357..925Z. doi:10.1126/science.aam9335. PMID 28860385. S2CID 206658036.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000076826 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044433 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Baines, A. J.; Bignone, P. A.; King, M. D.A.; Maggs, A. M.; Bennett, P. M.; Pinder, J. C.; Phillips, G. W. (2009-09-01). "The CKK Domain (DUF1781) Binds Microtubules and Defines the CAMSAP/ssp4 Family of Animal Proteins". Molecular Biology and Evolution. 26 (9): 2005–2014. doi:10.1093/molbev/msp115. ISSN 0737-4038. PMID 19508979. Archived from the original on 2022-06-15. Retrieved 2022-09-29.

[:0-6] Toya M, Kobayashi S, Kawasaki M, Shioi G, Kaneko M, Ishiuchi T, et al. (January 2016). "CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells". Proceedings of the National Academy of Sciences of the United States of America. 113 (2): 332–337. Bibcode:2016PNAS..113..332T. doi:10.1073/pnas.1520638113. PMC 4720291. PMID 26715742.

[7] Zenker J, White MD, Templin RM, Parton RG, Thorn-Seshold O, Bissiere S, Plachta N (September 2017). "A microtubule-organizing center directing intracellular transport in the early mouse embryo". Science. 357 (6354): 925–928. Bibcode:2017Sci...357..925Z. doi:10.1126/science.aam9335. PMID 28860385. S2CID 206658036.

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[6]

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Function

See also

References