Cyprazepam
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| Routes of administration | Oral |
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| Metabolism | Hepatic |
| Excretion | Renal |
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| Formula | C19H18ClN3O |
| Molar mass | 339.82 g·mol−1 |
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Cyprazepam[1] is a drug which is a sedative-hypnotic benzodiazepine derivative.[2][3][4][5] It has anxiolytic properties,[6] and presumably also has hypnotic, skeletal muscle relaxant, anticonvulsant and amnestic properties.
Synthesis
The lactam moiety in benzodiazepams is active towards nucleophiles and numerous analogues have been made by exploiting this fact.
For example, heating demoxepam with N-cyclopropylmethylamine leads to amidine formation, the minor tranquilizer cyprazepam.
See also
References
- ^ a b US 3138586, Wuest HM, "2-Cycloalkylamino Derivatives of 1,4-Benzodiazipines", issued 23 June 1964, assigned to Warner-Lambert Pharmaceutical Company; Chem. Abstr., 61: 7,032f (1964).
- ^ Oelschläger H, Martienssen D, Belal F (22 September 2006). "Ring Contraction of 1,4-Benzodiazepines to 3,4-Dihydroquinazolines During Macro Scale Reduction (Example 5: Cyprazepam)". Archiv der Pharmazie. 325 (8). Wiley Interscience: 503–507. doi:10.1002/ardp.19923250810. ISSN 0365-6233. S2CID 96638676. Archived from the original on 5 January 2013.
- ^ EP 1466628, Matthews B, Victor S, Nigel, Swindell C, "DHA-pharmaceutical agent conjugates", published 13 October 2004, assigned to American Regent Inc.
- ^ "Harmonized Tariff Schedule of the United States (2009) - Supplement 1 - PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE" (PDF). USA: United States International Trade Commission. 2009. Archived from the original (PDF) on 31 July 2009. Retrieved 19 September 2009.
- ^ Schafer EW, Bowles WA, Hurlbut J (May 1983). "The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one or more species of wild and domestic birds". Archives of Environmental Contamination and Toxicology. 12 (3): 355–82. Bibcode:1983ArECT..12..355S. doi:10.1007/BF01059413. PMID 6882015. S2CID 32956594.
- ^ World Health Organization (2006). "The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances" (PDF). USA: Ministry of health, Syria. Retrieved 19 September 2009. [dead link]
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