Nadoxolol

Nadoxolol
Names
	IUPAC name N′,3-Dihydroxy-4-naphthalen-1-yloxybutanimidamide
Identifiers
CAS Number	54063-51-3 ; 35991-93-6 (hydrochloride) ;
3D model (JSmol)	Interactive image;
ChemSpider	4886543;
EC Number	252-825-2;
MeSH	C006154
PubChem CID	6328253;
UNII	SK43HU1689 ; RZ9G589EN2 ;
CompTox Dashboard (EPA)	DTXSID90968903 ;
	InChI InChI=1S/C14H16N2O3/c15-14(16-18)8-11(17)9-19-13-7-3-5-10-4-1-2-6-12(10)13/h1-7,11,17-18H,8-9H2,(H2,15,16) Key: UPZVYDSBLFNMLK-UHFFFAOYSA-N; InChI=1/C14H16N2O3/c15-14(16-18)8-11(17)9-19-13-7-3-5-10-4-1-2-6-12(10)13/h1-7,11,17-18H,8-9H2,(H2,15,16) Key: UPZVYDSBLFNMLK-UHFFFAOYAW;
	SMILES C1=CC=C2C(=C1)C=CC=C2OCC(C/C(=N/O)/N)O;
Properties
Chemical formula	C14H16N2O3
Molar mass	260.293 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

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Nadoxolol is an antiarrhythmic agent (i.e., a drug for the treatment of irregular heartbeat),^[1] chemically related in structure to beta-adrenergic receptor blocker drugs such as propranolol.^[2]

It does not appear to be marketed anywhere in the world.

References

^ Warembourg, H; Ducloux, G (1976). "Clinical study of a new anti-arrhythmia agent: nadoxolol". Lille Med. 21 (4): 386–8. PMID 957857.
^ Kapoor, M; Anand, N; Koul, S; Chimni, SS; Manhas, KS; Raina, C; Parshad, R; Taneja, SC; Qazi, GN (2003). "Kinetic resolution of 1-chloro-3-(1-naphthyloxy)-2-propanol, an intermediate in the synthesis of beta-adrenergic receptor blockers". Bioorganic Chemistry. 31 (3): 259–69. doi:10.1016/s0045-2068(03)00050-6. PMID 12818235.

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[1] Warembourg, H; Ducloux, G (1976). "Clinical study of a new anti-arrhythmia agent: nadoxolol". Lille Med. 21 (4): 386–8. PMID 957857.

[2] Kapoor, M; Anand, N; Koul, S; Chimni, SS; Manhas, KS; Raina, C; Parshad, R; Taneja, SC; Qazi, GN (2003). "Kinetic resolution of 1-chloro-3-(1-naphthyloxy)-2-propanol, an intermediate in the synthesis of beta-adrenergic receptor blockers". Bioorganic Chemistry. 31 (3): 259–69. doi:10.1016/s0045-2068(03)00050-6. PMID 12818235.

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