Nojirimycin

Nojirimycin
Names
	IUPAC name (3R,4S,5R,6R)-6-(Hydroxymethyl)-2,3,4,5-piperidinetetrol
Identifiers
CAS Number	15218-38-9;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:28945;
ChemSpider	21864922;
KEGG	C06763;
PubChem CID	65242;
UNII	W40512EP9K;
	InChI InChI=1S/C6H13NO5/c8-1-2-3(9)4(10)5(11)6(12)7-2/h2-12H,1H2/t2-,3-,4+,5-,6?/m1/s1 Key: BGMYHTUCJVZIRP-GASJEMHNSA-N;
	SMILES C([C@@H]1[C@H]([C@@H]([C@H](C(N1)O)O)O)O)O;
Properties
Chemical formula	C6H13NO5
Molar mass	179.172 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

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Nojirimycin is the parent compound of a class of antibiotics and glycosidase inhibitors. Nojirimycin and its derivatives are mainly obtained from a class of Streptomyces species.^[1] Chemically, it is an iminosugar.

Derivatives

1-deoxynojirimycin or duvoglustat
1-deoxygalactonojirimycin or migalastat, a drug for the treatment of Fabry disease

References

^ Inouye, S.; Tsuruoka, T.; Ito, T.; Niida, T. (1968). "Structure and synthesis of nojirimycin". Tetrahedron. 24 (5): 2125–44. doi:10.1016/0040-4020(68)88115-3. PMID 5636917.

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[1] Inouye, S.; Tsuruoka, T.; Ito, T.; Niida, T. (1968). "Structure and synthesis of nojirimycin". Tetrahedron. 24 (5): 2125–44. doi:10.1016/0040-4020(68)88115-3. PMID 5636917.

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