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Pharmaceutical drug
Potassium canrenoate Other names SC-14266 AHFS /Drugs.com International Drug Names Routes of administration Intravenous ATC code Metabolism Hepatic Excretion Renal and fecal
potassium 3-[(8R ,9S ,10R ,13S ,14S ,17R )- 17-hydroxy-10,13-dimethyl-3-oxo-2,8,9, 11,12,14,15,16-octahydro-1H -cyclopenta[a] phenanthren-17-yl]propanoate
CAS Number PubChem CID DrugBank ChemSpider UNII ChEMBL CompTox Dashboard (EPA ) ECHA InfoCard 100.016.868 Formula C 22 H 29 K O 4 Molar mass 396.568 g·mol−1 3D model (JSmol )
[K+].[O-]C(=O)CC[C@]3(O)CC[C@H]2[C@@H]4/C=C\C1=C\C(=O)CC[C@@]1([C@H]4CC[C@@]23C)C
InChI=1S/C22H30O4.K/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21,26)12-8-19(24)25;/h3-4,13,16-18,26H,5-12H2,1-2H3,(H,24,25);/q;+1/p-1/t16-,17+,18+,20+,21+,22-;/m1./s1
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Potassium canrenoate (INN , JAN ) or canrenoate potassium (USAN ) (brand names Venactone , Soldactone ), also known as aldadiene kalium ,[ 1] the potassium salt of canrenoic acid , is an aldosterone antagonist of the spirolactone group.[ 2] Like spironolactone , it is a prodrug , and is metabolized to active canrenone in the body.[ 3] [ 4]
Potassium canrenoate is notable in that it is the only clinically used antimineralocorticoid which is available for parenteral administration (specifically intravenous )[ 4] [ 5] as opposed to oral administration .[ 6]
In the UK, it is unlicensed and only used for short term diuresis in oedema or heart failure in neonates or children under specialist initiation and monitoring.
See also
References
^ Selye H (17 April 2013). Hormones and Resistance: Part 1 and . Springer Science & Business Media. pp. 186–. ISBN 978-3-642-65192-2 .
^ Hill RA, Makin HL, Kirk DN, Murphy GM (23 May 1991). Dictionary of Steroids . CRC Press. pp. 656–. ISBN 978-0-412-27060-4 .
^ Burger A, Wolff ME (1996). Burger's Medicinal Chemistry and Drug Discovery: Therapeutic agents . Wiley. ISBN 978-0-471-57557-3 .
^ a b Waldmann C, Soni N, Rhodes A (27 November 2008). "Diurectics and the Critical Ill" . Oxford Desk Reference: Critical Care . OUP Oxford. pp. 187–. ISBN 978-0-19-922958-1 .
^ Santambrogio R, Barabino M, Opocher E (21 June 2017). "Non-resection: Radiofrequency Ablation, Cryo, Microwave" . In Bonjer HJ (ed.). Surgical Principles of Minimally Invasive Procedures: Manual of the European Association of Endoscopic Surgery (EAES) . Springer. pp. 136–. ISBN 978-3-319-43196-3 .
^ Kolkhof P, Bärfacker L (July 2017). "30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development" . The Journal of Endocrinology . 234 (1): T125–T140. doi :10.1530/JOE-16-0600 . PMC 5488394 . PMID 28634268 .
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