RH-34

RH-34
Clinical data
Routes of; administration	?
ATC code	none;
Legal status
Legal status	BR: Class F2 (Prohibited psychotropics); In general: uncontrolled;
Identifiers
	IUPAC name 3-[2-(2-methoxybenzylamino)ethyl]-1H-quinazoline-2,4-dione;
CAS Number	1028307-48-3 ;
PubChem CID	10041987;
ChemSpider	8217551 ;
UNII	A31AED225O;
CompTox Dashboard (EPA)	DTXSID80434687 ;
Chemical and physical data
Formula	C18H19N3O3
Molar mass	325.368 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1C=2C(NC(=O)N1CCNCC3=C(OC)C=CC=C3)=CC=CC2;
	InChI InChI=1S/C18H19N3O3/c1-24-16-9-5-2-6-13(16)12-19-10-11-21-17(22)14-7-3-4-8-15(14)20-18(21)23/h2-9,19H,10-12H2,1H3,(H,20,23) ; Key:NUAJBITWGGTZCM-UHFFFAOYSA-N ;
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RH-34 is a compound which acts as a potent and selective partial agonist for the 5-HT_2A serotonin receptor subtype. It was derived by structural modification of the selective 5-HT_2A antagonist ketanserin, with the 4-(p-fluorobenzoyl)piperidine moiety replaced by the N-(2-methoxybenzyl) pharmacophore found in such potent 5-HT_2A agonists as NBOMe-2C-B and NBOMe-2C-I. This alteration was found to retain 5-HT_2A affinity and selectivity, but reversed activity from an antagonist to a moderate efficacy partial agonist.^[2]^[3]^[4]

Legal status

RH-34 is a controlled substance in Hungary^[5] and Brazil.^[6]

References

^ Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
^ Ralf Heim. Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts. (German)
^ Maria Silva. Theoretical study of the interaction of agonists with the 5-HT2A receptor. Universität Regensburg, 2009.
^ Silva ME, Heim R, Strasser A, Elz S, Dove S (January 2011). "Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor". Journal of Computer-aided Molecular Design. 25 (1): 51–66. Bibcode:2011JCAMD..25...51S. CiteSeerX 10.1.1.688.2670. doi:10.1007/s10822-010-9400-2. PMID 21088982. S2CID 3103050.
^ A Magyarországon megjelent, a Kábítószer és Kábítószer-függőség Európai Megfigyelő Központjának Korai Jelzőrendszerébe (EMCDDA EWS) 2005 óta bejelentett ellenőrzött anyagok büntetőjogi vonatkozású besorolása
^ Anvisa

[1] Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.

[2] Ralf Heim. Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts. (German)

[3] Maria Silva. Theoretical study of the interaction of agonists with the 5-HT2A receptor. Universität Regensburg, 2009.

[pmid21088982-4] Silva ME, Heim R, Strasser A, Elz S, Dove S (January 2011). "Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor". Journal of Computer-aided Molecular Design. 25 (1): 51–66. Bibcode:2011JCAMD..25...51S. CiteSeerX 10.1.1.688.2670. doi:10.1007/s10822-010-9400-2. PMID 21088982. S2CID 3103050.

[5] A Magyarországon megjelent, a Kábítószer és Kábítószer-függőség Európai Megfigyelő Központjának Korai Jelzőrendszerébe (EMCDDA EWS) 2005 óta bejelentett ellenőrzött anyagok büntetőjogi vonatkozású besorolása

[6] Anvisa

[1]

[2]

[3]

[4]

[5]

[6]

Legal status

See also

References