Hlorfenesin

Hlorfenesin
(IUPAC) ime
	(3-(4-hlorofenoksi)-2-hidroksipropil)karbamat
Klinički podaci
AHFS/Drugs.com	Mikromedeks, detaljne potrošačke informacije
Identifikatori
CAS broj	886-74-8
ATC kod	D01AE07
PubChem	2724
ChemSpider	2623
UNII	I670DAL4SZ
KEGG	D00770
ChEBI	CHEBI:3642
ChEMBL	CHEMBL607710
Hemijski podaci
Formula	C10H12ClNO4
Mol. masa	245,660 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C10H12ClNO4/c11-7-1-3-9(4-2-7)15-5-8(13)6-16-10(12)14/h1-4,8,13H,5-6H2,(H2,12,14); Key: SKPLBLUECSEIFO-UHFFFAOYSA-N
Fizički podaci
Tačka topljenja	86–92 °C (187–198 °F)
Farmakokinetički podaci
Izlučivanje	urine
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Hlorfenesin (Maolate, Musil) je centralno delujući miorelaksant, koji se nekad koristio za tretiranje mišićnog bola i spazama.^[6]^[7] Hlorfenesin nije više u upotrebi za te svrhe u većini razvijenih zemalja, jer su dostupni znatno bezbedniji spasmolitici poput benzodiazepina.

Drugi centralni efekti su sedacija, anksiolitičko dejstvo, i nesvestica. On takođe ima antifungalna i antibakterijska svojstva.^[8]

Hemija

Hlorfenesin, 3-(4-hlorofenoksi)-1,2-propanediol, se može sintetisati slično metokarbamolu iz 3-(4-hlorofenoksi)-1,2-propanediola.^[9]^[10]^[11]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Okuyama S, Aihara H (1987). „Antinociceptive effect of chlorphenesin carbamate in adjuvant arthritic rats”. Research communications in chemical pathology and pharmacology 55 (2): 147–60. PMID 3823606.
↑ Kurachi M, Aihara H (1984). „Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats”. Japanese journal of pharmacology 36 (1): 7–13. DOI:10.1254/jjp.36.7. PMID 6503049.
↑ ATC code D01AE07
↑ J.R. Collins, M. Richard, U.S. Patent 3.161.567 (1964)
↑ H.E. Perker, U.S. Patent 3.214.336 (1965)
↑ J. Forrest, W. Bradley, GB 628497 (1948)

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Okuyama S, Aihara H (1987). „Antinociceptive effect of chlorphenesin carbamate in adjuvant arthritic rats”. Research communications in chemical pathology and pharmacology 55 (2): 147–60. PMID 3823606.

[7] Kurachi M, Aihara H (1984). „Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats”. Japanese journal of pharmacology 36 (1): 7–13. DOI:10.1254/jjp.36.7. PMID 6503049.

[8] ATC code D01AE07

[9] J.R. Collins, M. Richard, U.S. Patent 3.161.567 (1964)

[10] H.E. Perker, U.S. Patent 3.214.336 (1965)

[11] J. Forrest, W. Bradley, GB 628497 (1948)

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