Alcohol dehydrogenase (nicotinoprotein) (EC 1.1.99.36, NDMA-dependent alcohol dehydrogenase, nicotinoprotein alcohol dehydrogenase, np-ADH, ethanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase) is an enzyme with system name ethanol:acceptor oxidoreductase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
| Alcohol dehydrogenase (nicotinoprotein) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.99.36 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- ethanol + acceptor acetaldehyde + reduced acceptor
This enzyme contains Zn2+.
References
- ^ Van Ophem, P.W., Van Beeumen, J. and Duine, J.A. (1993). "Nicotinoprotein [NAD(P)-containing] alcohol/aldehyde oxidoreductases. Purification and characterization of a novel type from Amycolatopsis methanolica". Eur. J. Biochem. 212 (3): 819–826. doi:10.1111/j.1432-1033.1993.tb17723.x. PMID 8385013.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Piersma, S.R., Visser, A.J., de Vries, S. and Duine, J.A. (1998). "Optical spectroscopy of nicotinoprotein alcohol dehydrogenase from Amycolatopsis methanolica: a comparison with horse liver alcohol dehydrogenase and UDP-galactose epimerase". Biochemistry. 37 (9): 3068–3077. doi:10.1021/bi972115u. PMID 9485460.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Schenkels, P. and Duine, J.A. (2000). "Nicotinoprotein (NADH-containing) alcohol dehydrogenase from Rhodococcus erythropolis DSM 1069: an efficient catalyst for coenzyme-independent oxidation of a broad spectrum of alcohols and the interconversion of alcohols and aldehydes". Microbiology. 146: 775–785. PMID 10784035.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Piersma, S.R., Norin, A., de Vries, S., Jornvall, H. and Duine, J.A. (2003). "Inhibition of nicotinoprotein (NAD+-containing) alcohol dehydrogenase by trans-4-(N,N-dimethylamino)-cinnamaldehyde binding to the active site". J. Protein Chem. 22 (5): 457–461. doi:10.1023/b:jopc.0000005461.53788.ee. PMID 14690248.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Norin, A., Piersma, S.R., Duine, J.A. and Jornvall, H. (2003). "Nicotinoprotein (NAD+ -containing) alcohol dehydrogenase: structural relationships and functional interpretations". Cell. Mol. Life Sci. 60 (5): 999–1006. doi:10.1007/s00018-003-3105-9. PMID 12827287.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
External links
- Alcohol+dehydrogenase+(nicotinoprotein) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)