Mill Creek is an ambiguous placename used in the United States and Canada:
Communities
- Mill Creek, California, a town in Tehama County
- Millcreek, Florida, a rural community in St. Johns County, near St. Augustine
- Mill Creek, Georgia, a rural community in Whitfield County
- Mill Creek Towne, Maryland, an unincorporated community in Montgomery County near Rockville (also the location of Mill Creek Towne Elementary School)
- Mill Creek Township, Lycoming County, Pennsylvania
- Mill Creek Township, Mercer County, Pennsylvania
- Millcreek and East Millcreek, Utah, census-designated places in Salt Lake County
- Mill Creek, Washington, a city in Snohomish County
- Mill Creek, West Virginia, a town in Randolph County
Streams
- Mill Creek (Clarion River), a tributary of the Clarion River in Pennsylvania
- Mill Creek (Conestoga River), a tributary of the Conestoga River in Pennsylvania
- Mill Creek (Northern California), a tributary of the Sacramento River
- Mill Creek (Ohio), a tributary of the Ohio River
- Mill Creek (Opequon Creek tributary), a tributary of Opequon Creek in Berkeley County, West Virginia
- Mill Creek (Patterson Creek tributary), a tributary of Patterson Creek in Mineral County, West Virginia
- Mill Creek (Southern California), a tributary of the Santa Ana River in San Bernardino County
- Mill Creek (South Branch Potomac River tributary), a tributary of the South Branch Potomac River in Hampshire County, West Virginia
- Mill Creek (Tehama County, California), a tributary of the Sacramento River
- Mill Creek (Tioga River), a tributary of the Tioga River in Pennsylvania
- Mill Creek (Edmonton, Alberta), a tributary of the North Saskatchewan River
Other uses
- Mill Creek Landing, a subdivision in Buford, Georgia opened in 2004. It's also a home of Mill Creek High School
- Mill Creek School in Philadelphia, Pennsylvania
- Mill Creek (brand), a brand of personal hygiene products
- Mill Creek School in Edmonton, Alberta