Lipoblastomatosis
| Benign lipoblastomatosis | |
|---|---|
| Other names | Embryonic lipoma[1] |
| Specialty | Dermatology |
Benign lipoblastomatosis is a tumor consisting of fetal-embryonal adipocytes, frequently confused with a liposarcoma, affecting exclusively infants and young children, with approximately 90% of cases occurring before 3 years of age.[2][3]: 626 The term lipoblastomatosis was first used by Vellios et al. in 1958, at which point the tumor became generally accepted as a distinctive entity.[4][5] Today Diffuse lipoblastoma is the preferred term for lipoblastomatosis.[6][7] The tumor is rare, accounting for less than 1% of all childhood neoplasm,[8] and it has been found to be more common in males than females.[9][8] It often presents as an asymptomatic rapidly enlarging mass, occurring more often in the soft tissues of the extremities.[8][9]
Signs and symptoms
[edit]Although they have also been reported in the head and neck, shoulder, groin, axilla, back, and abdominal cavity, these tumors typically manifest in the extremities.[10] Although it is normally painless, it may cause symptoms such as vomiting, stomach pain, paralysis, or fecal or urinary incontinence, depending on where the mass is anatomically.[11][12]
Causes
[edit]Lipoblastomatosis most likely results from new adipose tissue lobules and lipoblasts proliferating throughout the neonatal period.[10]
Diagnosis
[edit]Although imaging modalities like magnetic resonance imaging (MRI) and computed tomography (CT) can be useful, histology confirmation is necessary for an accurate diagnosis.[10]
Treatment
[edit]Prompt surgical resection is the advised course of treatment for lipoblastomatosis, particularly if the mass is close to any important organs.[10]
See also
[edit]References
[edit]- ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
- ^ Kumar, A.; Brierley, D.; Hunter, K.D.; Lee, N. (November 2015). "Rapidly-growing buccal mass in a 6-month-old infant". British Journal of Oral and Maxillofacial Surgery. 53 (9): 888–890. doi:10.1016/j.bjoms.2015.07.006. PMID 26250364.
- ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
- ^ Vellios, F; Baez, J; Shumacker, HB (November 1958). "Lipoblastomatosis: a tumor of fetal fat different from hibernoma; report of a case, with observations on the embryogenesis of human adipose tissue". The American Journal of Pathology. 34 (6): 1149–59. PMC 1934796. PMID 13583102.
- ^ Gammelgaard, Niels; Jørgensen, Karstein; Lund, Claus (July 1983). "Benign Lipoblastoma in the Neck Causing Respiratory Insufficiency". The Laryngoscope. 93 (7): 935–937. doi:10.1288/00005537-198307000-00017. PMID 6865630. S2CID 35331275.
- ^ Robinson, Philip; Vanhoenacker, Filip M. (2017). "Adipocytic Tumors". Imaging of Soft Tissue Tumors. pp. 197–241. doi:10.1007/978-3-319-46679-8_12. ISBN 978-3-319-46677-4.
- ^ Ahlawat, Shivani; M. Fayad, Laura (2020). "Revisiting the WHO classification system of soft tissue tumours: emphasis on advanced magnetic resonance imaging sequences. Part 1". Polish Journal of Radiology. 85 (1): 396–408. doi:10.5114/pjr.2020.98685. PMC 7509695. PMID 32999693.
- ^ a b c Kamal, Achmad Fauzi; Wiratnaya, I. Gde Eka; Hutagalung, Errol Untung; Prasetyo, Marcel; Kodrat, Evelina; Widodo, Wahyu; Effendi, Zuhri; Husodo, Kurniadi (2014-09-15). "Lipoblastoma and Lipoblastomatosis of the Lower Leg". Case Reports in Orthopedics. 2014: 582876. doi:10.1155/2014/582876. PMC 4181785. PMID 25302126.
- ^ a b Calobrisi, Stella D.; Garland, Jeffery S.; Esterly, Nancy B. (1998). "Congenital Lipoblastomatosis of the Lower Extremity in a Neonate". Pediatric Dermatology. 15 (3): 210–213. doi:10.1111/j.1525-1470.1998.tb01318.x. PMID 9655318. S2CID 45439781.
- ^ a b c d Jain, Rhea; Betancourt, Renée L.; Rose, Austin S. (2021). "Lipoblastomatosis: An unusual midline neck mass in a young child". International Journal of Pediatric Otorhinolaryngology. 140. Elsevier BV: 110544. doi:10.1016/j.ijporl.2020.110544. ISSN 0165-5876. PMID 33296835.
- ^ Mo, Zhiqiang; Xie, Xianghui; Wang, Huanmin; Qin, Hong; Han, Wei; Li, Xiaosong (2017). "Analysis of diagnosis and treatment of lipoblastomatosis". Science China Life Sciences. 60 (7): 778–780. doi:10.1007/s11427-017-9088-6. ISSN 1674-7305. PMID 28639103.
- ^ Collins, Margaret H.; Chatten, Jane (1997). "Lipoblastoma/Lipoblastomatosis: A Clinicopathologic Study of 25 Tumors". The American Journal of Surgical Pathology. 21 (10). Ovid Technologies (Wolters Kluwer Health): 1131–1137. doi:10.1097/00000478-199710000-00002. ISSN 0147-5185. PMID 9331284.
Further reading
[edit]- Hicks, John; Dilley, Anthony; Patel, Dimple; Barrish, James; Zhu, Shen-Hua; Brandt, Mary (2001). "Lipoblastoma and Lipoblastomatosis in Infancy and Childhood: Histopathologic, Ultrastructural, and Cytogenetic Features". Ultrastructural Pathology. 25 (4): 321–333. doi:10.1080/019131201753136359. ISSN 0191-3123. PMID 11577778.
- Dutton, Jonathan J.; Escaravage, George K.; Fowler, Amy M.; Wright, John D. (2011). "Lipoblastomatosis: Case Report and Review of the Literature". Ophthalmic Plastic & Reconstructive Surgery. 27 (6): 417–421. doi:10.1097/IOP.0b013e318221118c. ISSN 0740-9303. PMID 21743369.