Anti-p62 antibodies
| Autoantibody | |
|---|---|
| Anti-p62 | |
| Autoantigen Isoform |
Nucleoporin 62kDA |
| Autoantigen gene | NUP62 |
| Affected organ(s) | Bile Duct |
| Associated Disease(s) |
Primary biliary cirrhosis |
| HLA associations | DR2 (weak) |
Anti-p62 antibodies (AP62A) are found in a primary biliary cirrhosis.[1] p62 is also more frequent in Stage IV primary biliary cirrhosis and is prognostic for severe disease.[2][3] The autoantigen is the nucleoporin 62kDA protein.
References
- ^ Wesierska-Gadek J, Hohenuer H, Hitchman E, Penner E (1996). "Autoantibodies against nucleoporin p62 constitute a novel marker of primary biliary cirrhosis". Gastroenterology. 110 (3): 840–7. PMID 8608894.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Miyachi K, Hankins RW, Matsushima H; et al. (2003). "Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study". J. Autoimmun. 20 (3): 247–54. PMID 12753810.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - ^ Invernizzi P, Selmi C, Ranftler C, Podda M, Wesierska-Gadek J (2005). "Antinuclear antibodies in primary biliary cirrhosis". Semin. Liver Dis. 25 (3): 298–310. doi:10.1055/s-2005-916321. PMID 16143945.
{{cite journal}}: CS1 maint: multiple names: authors list (link)