Theoretical ecology
Theoretical ecology is the study of life and its interactions with environment from a metaphysical standpoint. An example question that has been addressed in this field is one posed by physicist Erwin Schrodinger who asked, "What is life?"
Mathematician Robert Rosen tackled this question but reframed it in the process. In his 1991 book, "Life Itself", Rosen suggests that a better question is, "Why are organisms different than machines?" His answer addresses the unfractionability, or self-causing holism, of life; he states "a material system is an organism if, and only if, it is closed to efficient causation." The supporting work behind this definition of life embodies his "relational theory of systems". The paradigm behind this theory represents a radical departure from the mainstream mechanical and reductionist paradigm dating back to Newton and Descartes.