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Pyruvate dehydrogenase complex

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Pyruvate dehydrogenase is an allosteric enzyme that transforms pyruvate into Acetyl-CoA which is then used in the citric acid cycle.

It is inhibited when either of the three following ratios are increased: [ATP]/[ADP], [NADH]/[NAD+] and [Acetyl-CoA]/[CoASH].

Pyruvate dehydrogenase is actually a big complex composed of 60 subunits: 24 pyruvate dehydrogenase (E1), 24 dihydrolipoyl transacetylase (E2) and 12 dihydrolipoyl dehydrogenase (E3).

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