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Aaron Ciechanover

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Aaron Ciechanover (born 1947) is an Israeli biologist. Along with Avram Hershko and Irwin Rose, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation.

Born in Haifa, Israel, he received his Master of Science in 1971 and his M.D. in 1974 from the Hadassah Medical School of the Hebrew University in Jerusalem. He received his doctorate in medicine in 1982 from the Technion (Israel Institutite of Technology), in Haifa. He is currently a Professor in the Unit of Biochemistry and Director of the Rappaport Family Institute for Research in Medical Sciences at the Technion.

References

  • Hershko, A., Ciechanover, A., and Rose, I.A. (1979) "Resolution of the ATP-dependent proteolytic system from reticulocytes: A component that interacts with ATP". Proc. Natl. Acad. Sci. USA 76, pp. 3107-3110.
  • Hershko, A., Ciechanover, A., Heller, H., Haas, A.L., and Rose I.A. (1980) "Proposed role of ATP in protein breakdown: Conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis". Proc. Natl. Acad. Sci. USA 77, pp. 1783-1786.
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