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Pantoprazole

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This is an old revision of this page, as edited by Yendor33 (talk | contribs) at 21:18, 30 July 2006 (Corrected Legal Status from "Approved" to "By Prescription Only"). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Pantoprazole
Clinical data
Pregnancy
category
  • B (United States)
Routes of
administration		Oral and Intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability77%
MetabolismHepatic
Elimination half-life1 hour
ExcretionRenal
Identifiers
  • 5-(difluoromethoxy)- 2-[(3,4-dimethoxypyridin-2-yl) methylsulfinyl]- 3H-benzoimidazole
CAS Number
PubChem CID
DrugBank
CompTox Dashboard (EPA)
ECHA InfoCard100.111.005 Edit this at Wikidata
Chemical and physical data
FormulaC16H15F2N3O4S
Molar mass383.371

Pantoprazole (marketed under the brand names Protium, Protonix, Pantozol, "Pantor" and Pantoloc) is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. Initial treatment is generally of eight weeks' duration, after which another eight week course of treatment may be considered if necessary. It can be used as a maintenance therapy for long term use after initial response is obtained.

Pharmacology

Pantoprazole is metabolized in the liver by the cytochrome P450 system. Metabolism mainly consists of demethylation by CYP2C19 followed by sulfation. Another metabolic pathway is oxidation by CYP3A4. Pantoprazole metabolites are not thought to have any pharmacological significance.

Availability

Pantoprazole was developed by Altana and is currently marketed under the brand name Protonix® by Wyeth-Ayerst Laboratories, Somac® by Pfizer "Pantor®" by Bosnalijek, and as Pantoloc® by Solvay Pharma and as Protium in the UK. It is available by prescription in controlled-release tablets. It is also available for intraveinous use. This is the only benzimidazole available in USA for use as injection. Other benzimidazoles like Omeprazole/ Esomeprazole are not available for I.V. use in USA.

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
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