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Suppressor T cell

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This is an old revision of this page, as edited by Ramujana (talk | contribs) at 12:21, 29 October 2004 (→‎Suppressor T cell). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Suppressor T cell

There were debates over the existence of supressor cells, but recent years studies have confirmed a central role of suppressor cell populations in regulating immunity. Naturally occuring supressor T cells (renamed regulatory T cells - T reg) belongs to CD4+ subpopulation and express CD25+ (interleukin-2 IL-2 alpha chain), transcription factor FoxP and GITR (glucocorticoid-induced TBF receptor). They mature in thymus and comprise ~5-10% of the peripheral blood CD4+ helper T cell subpopulation in mice. Absence of T reg or its dysfunction is associated with severe autoimmunity and tumors. Normaly T reg exibit supresor-regulatory activity by TGF beta, interleukin-10 (IL-10) and direct acctions.

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