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Antibody-dependent cellular cytotoxicity

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This is an old revision of this page, as edited by CmdrObot (talk | contribs) at 22:29, 27 August 2006 (sp (3): Dependant→Dependent, dependant→dependent). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Cell mediated immunity is the opposite arm to the humoral counterpart of the immune system. This contains within it three main mechanisms of killing infected cells (i.e. viral invasion); Natural Killer Cells (NK Cells); Cytotoxic T-Lymphocytes (CTL) and Antibody-Dependent Cellular Cytotoxicity (ADCC).

Antibody-Dependent Cellular Cytotoxicity

ADCC is the least understood of the three mechanisms, it is mediated by either NK cells or CTL. The action of ADCC is dependent on the recognition of the objective cell by antibodies attached on the surface of the effector cell (terminally differentiated leukocyte). This process is part of the adaptive immune response due to the dependence on antibodies and therefore a former anti-body response is required for this mechanism to take effect and be effective against an invading pathogen.

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