BH3 interacting-domain death agonist
| BH3 interacting domain death agonist | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | BID | ||||||
| NCBI gene | 637 | ||||||
| HGNC | 1050 | ||||||
| OMIM | 601997 | ||||||
| RefSeq | NM_001196 | ||||||
| UniProt | P55957 | ||||||
| Other data | |||||||
| Locus | Chr. 22 q11.2 | ||||||
| |||||||
The BH3 interacting domain death agonist, or BID, is a pro-apoptotic member of the Bcl-2 protein family.[1] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of BID is regulated by the tumor suppressor p53, and BID has been shown to be involved in p53-mediated apoptosis.[2]
See also
- Apoptosis
- Apoptosome
- Bcl-2
- Bcl-2-associated_X_protein (BAX)
- Caspases
- Cytochrome c
- Noxa
- Mitochondrion
- p53 upregulated modulator of apoptosis (PUMA)
References
- ^
Wang, K. (1996). "BID: a novel BH3 domain-only death agonist". Genes Dev. 10: 2859–2869.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help) - ^
Sax, J. K. (2002). "BID regulation by p53 contributes to chemosensitivity". Nat. Cell Biol. 4: 842–849.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help)