alt = A tube diagram representing the linear amino acid sequence of the preproprotein C (461 amino acids long) and mature heterodimer (light + heavy chains) highlighting the locations of the signal (1-32), gla (43-88), EGF-1 (97-132), EGF-2 (136-176), activation peptide (200-211), and serine protease (212-450) domains. The light (43-197) and heavy (212-461) chains of the heterodimer are joined by a line representing a disulfide bond between cysteine residues 183 and 319.
alt = Schematic diagram of the blood coagulation (thrombin; left) and protein C (right) pathways. In the blood coagulation pathway, thrombin acts to convert factor Xi to XIa, VIII to VIIIa, V to Va, fibrinogen to fibrin. In addition, thrombin promotes platelet activation and aggregation via activation of protease-activated receptors on the cell membrane of the platelet. Thrombin also cross over into the protein C pathway by converting protein C into APC. APC in turn converts factor V into Vi, and VIIIa into VIIIi. Finally APC activates PAR-1 and EPCR.
Un RAF CH-47 Chinook; Chinooks eran esenciales para la evacuación y apoyado las operaciones más tarde británicos en Sierra Leona, pero a medida que la RAF no tenía la capacidad para transportarlos intacto, dos tuvieron que volar a Freetown desde el Reino Unido.
