PELO

PELO
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1X52
Identifikatori
Aliasi	PELO
Vanjski ID-jevi	OMIM: 605757 MGI: 2145154 HomoloGene: 6835 GeneCards: PELO
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	52,804,044 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	115,226,722 bp
Ontologija gena
Molekularna funkcija	• endonuclease activity; • nuclease activity; • hydrolase activity; • vezivanje iona metala; • GO:0001948, GO:0016582 vezivanje za proteine; • ribosome binding;
Ćelijska komponenta	• jedro; • citoplazma;
Biološki proces	• ćelijski ciklus; • RNA surveillance; • Ćelijska proliferacija; • nuclear-transcribed mRNA catabolic process, non-stop decay; • GO:0051312, GO:0007083 chromosome organization; • nucleic acid phosphodiester bond hydrolysis; • Ćelijska dioba; • Biosinteza bjelančevina; • endoderm development; • stem cell population maintenance; • positive regulation of BMP signaling pathway; • ribosome disassembly; • mesenchymal to epithelial transition; • nonfunctional rRNA decay; • nuclear-transcribed mRNA catabolic process, no-go decay; • inner cell mass cell proliferation;
	Izvori:Amigo / QuickGO
Ortolozi
	53918
	105083
	ENSG00000152684
	ENSMUSG00000042275
	Q9BRX2
	Q80X73
	NM_015946
	NM_134058
	NP_057030
	NP_598819
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Pregledana verzija ove stranice, odobrena dana 3 novembar 2021, zasnovana je na ovoj izmjeni.

Homolog proteina pelota jest protein koji je kod ljudi kodiran genom PELO sa hromosoma 5.^[5]^[6]

Funkcija

Ovaj gen kodira protein koji sadrži konzervirani signal jedarne lokalizacije. Kodirani protein može imati ulogu u spermatogenezi, kontroli ćelijskog ciklusa i u mejotskoj ćelijskoj diobi.^[6] U kvascima, kompleks Dom34-Hbs1 (s ABCE1) odgovoran je za reaktivaciju ribosoma i za oporavak onih zaglavljenih na iRNK.^[7] To je paralog faktora oslobađanja eRF1.

Homolog u rodu Drosophila prvi put je otkriven 1993. Mutanti pokazuju zaustavljanje ćeliskog ciklusa u G2/M fazi mejoze i veliki nebenkern oblik u kasnim spermatocitima.^[8] Homolozi ljudi, kvasaca (Dom34), glista i biljaka prijavljeni su 1995.,^[9] a slijedio je jedan pronađen u Archaea.^[10]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152684 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042275 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shamsadin R, Adham IM, von Beust G, Engel W (Nov 2000). "Molecular cloning, expression and chromosome location of the human pelota gene PELO". Cytogenetics and Cell Genetics. 90 (1–2): 75–8. doi:10.1159/000015667. PMID 11060452. S2CID 35316587.
^ ^a ^b "Entrez Gene: PELO pelota homolog (Drosophila)".
^ van den Elzen AM, Schuller A, Green R, Séraphin B (februar 2014). "Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress". The EMBO Journal. 33 (3): 265–76. doi:10.1002/embj.201386123. PMC 3989619. PMID 24424461.
^ Castrillon DH, Gönczy P, Alexander S, Rawson R, Eberhart CG, Viswanathan S, et al. (oktobar 1993). "Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis". Genetics. 135 (2): 489–505. PMC 1205651. PMID 8244010.
^ Eberhart CG, Wasserman SA (oktobar 1995). "The pelota locus encodes a protein required for meiotic cell division: an analysis of G2/M arrest in Drosophila spermatogenesis". Development. 121 (10): 3477–86. PMID 7588080.
^ Ragan MA, Logsdon JM, Sensen CW, Charlebois RL, Doolittle WF (novembar 1996). "An archaebacterial homolog of pelota, a meiotic cell division protein in eukaryotes". FEMS Microbiology Letters. 144 (2–3): 151–5. doi:10.1111/j.1574-6968.1996.tb08522.x. PMID 8900058.

Dopunska literatura

Cheli Y, Kanaji S, Jacquelin B, Chang M, Nugent DJ, Kunicki TJ (2007). "Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1769 (9–10): 546–58. doi:10.1016/j.bbaexp.2007.06.004. PMC 2682338. PMID 17669516.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (novembar 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (januar 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (maj 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152684 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042275 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11060452-5] Shamsadin R, Adham IM, von Beust G, Engel W (Nov 2000). "Molecular cloning, expression and chromosome location of the human pelota gene PELO". Cytogenetics and Cell Genetics. 90 (1–2): 75–8. doi:10.1159/000015667. PMID 11060452. S2CID 35316587.

[entrez-6] "Entrez Gene: PELO pelota homolog (Drosophila)".

[7] van den Elzen AM, Schuller A, Green R, Séraphin B (februar 2014). "Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress". The EMBO Journal. 33 (3): 265–76. doi:10.1002/embj.201386123. PMC 3989619. PMID 24424461.

[8] Castrillon DH, Gönczy P, Alexander S, Rawson R, Eberhart CG, Viswanathan S, et al. (oktobar 1993). "Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis". Genetics. 135 (2): 489–505. PMC 1205651. PMID 8244010.

[9] Eberhart CG, Wasserman SA (oktobar 1995). "The pelota locus encodes a protein required for meiotic cell division: an analysis of G2/M arrest in Drosophila spermatogenesis". Development. 121 (10): 3477–86. PMID 7588080.

[10] Ragan MA, Logsdon JM, Sensen CW, Charlebois RL, Doolittle WF (novembar 1996). "An archaebacterial homolog of pelota, a meiotic cell division protein in eukaryotes". FEMS Microbiology Letters. 144 (2–3): 151–5. doi:10.1111/j.1574-6968.1996.tb08522.x. PMID 8900058.

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