UTP20

UTP20
Identifiers
Aliases	UTP20, DRIM, 1A6/DRIM, small subunit processome component, UTP20 small subunit processome component
External IDs	OMIM: 612822; MGI: 1917933; HomoloGene: 38373; GeneCards: UTP20; OMA:UTP20 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	101,386,618 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	88,662,666 bp
RNA expression pattern
	Top expressed in
	testicle; ; tendon of biceps brachii; ; minor salivary glands; ; gonad; ; Achilles tendon; ; ventricular zone; ; secondary oocyte; ; optic nerve; ; stromal cell of endometrium; ; gastrocnemius muscle;
	Top expressed in
	primitive streak; ; endothelial cell of lymphatic vessel; ; epiblast; ; secondary oocyte; ; primary oocyte; ; tail of embryo; ; mandibular prominence; ; hair follicle; ; maxillary prominence; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	cytoplasm; preribosome, small subunit precursor; small-subunit processome; nucleolus; nucleus; 90S preribosome; nucleoplasm; plasma membrane;
Biological process	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); negative regulation of cell population proliferation; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); rRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	27340
	70683
	ENSG00000120800
	ENSMUSG00000004356
	O75691
	Q5XG71
	NM_014503
	NM_175158
	NP_055318
	NP_780367
	Wikidata
View/Edit Human	View/Edit Mouse

Small subunit processome component 20 homolog is a protein that in humans is encoded by the UTP20 gene.^[5]^[6]^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120800 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004356 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schwirzke M, Gnirke A, Bork P, Tarin D, Weidle UH (Aug 1998). "Differential gene expression in mammary carcinoma cell lines: identification of DRIM, a new gene down-regulated in metastasis". Anticancer Res. 18 (3A): 1409–21. PMID 9673349.
^ Bernstein KA, Gallagher JE, Mitchell BM, Granneman S, Baserga SJ (Dec 2004). "The small-subunit processome is a ribosome assembly intermediate". Eukaryot Cell. 3 (6): 1619–26. doi:10.1128/EC.3.6.1619-1626.2004. PMC 539036. PMID 15590835.
^ Peng WT, Robinson MD, Mnaimneh S, Krogan NJ, Cagney G, Morris Q, Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B, Wu LF, Altschuler SJ, Roweis S, Frey BJ, Emili A, Greenblatt JF, Hughes TR (Jul 2003). "A panoramic view of yeast noncoding RNA processing". Cell. 113 (7): 919–33. doi:10.1016/S0092-8674(03)00466-5. PMID 12837249. S2CID 10190539.
^ "Entrez Gene: UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)".

Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Goodison S, Viars C, Grazzini M, Urquidi V (2004). "The interrelationship between DRIM gene expression and cytogenetic and phenotypic characteristics in human breast tumor cell lines". BMC Genomics. 4 (1): 39. doi:10.1186/1471-2164-4-39. PMC 222913. PMID 14503924.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Xing X, Du X, Lu Z, Ning T, Su X, Ke Y (2005). "Characterization of the promoter of 1A6/DRIM, a novel cancer-related gene and identification of its transcriptional activator". Gene. 344: 161–9. doi:10.1016/j.gene.2004.09.036. PMID 15656982.
Yang L, Zhao J, Lü W, Li Y, Du X, Ning T, Lu G, Ke Y (2006). "KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential". Biochem. Biophys. Res. Commun. 334 (3): 884–90. doi:10.1016/j.bbrc.2005.06.179. PMID 16053918.
Liu J, Du X, Ke Y (2006). "Mapping nucleolar localization sequences of 1A6/DRIM". FEBS Lett. 580 (5): 1405–10. Bibcode:2006FEBSL.580.1405L. doi:10.1016/j.febslet.2006.01.064. PMID 16458307. S2CID 29337295.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Wang Y, Liu J, Zhao H, Lü W, Zhao J, Yang L, Li N, Du X, Ke Y (2007). "Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing". Biochim. Biophys. Acta. 1773 (6): 863–8. doi:10.1016/j.bbamcr.2007.04.002. PMID 17498821.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120800 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004356 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9673349-5] Schwirzke M, Gnirke A, Bork P, Tarin D, Weidle UH (Aug 1998). "Differential gene expression in mammary carcinoma cell lines: identification of DRIM, a new gene down-regulated in metastasis". Anticancer Res. 18 (3A): 1409–21. PMID 9673349.

[pmid15590835-6] Bernstein KA, Gallagher JE, Mitchell BM, Granneman S, Baserga SJ (Dec 2004). "The small-subunit processome is a ribosome assembly intermediate". Eukaryot Cell. 3 (6): 1619–26. doi:10.1128/EC.3.6.1619-1626.2004. PMC 539036. PMID 15590835.

[pmid12837249-7] Peng WT, Robinson MD, Mnaimneh S, Krogan NJ, Cagney G, Morris Q, Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B, Wu LF, Altschuler SJ, Roweis S, Frey BJ, Emili A, Greenblatt JF, Hughes TR (Jul 2003). "A panoramic view of yeast noncoding RNA processing". Cell. 113 (7): 919–33. doi:10.1016/S0092-8674(03)00466-5. PMID 12837249. S2CID 10190539.

[entrez-8] "Entrez Gene: UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)".

[5]

[6]

[7]

[8]

[1]

[2]

[3]

[4]

UTP20

References

Further reading