UTP20
Homolog male podjedinice procesomne komponente 20 je protein koji je kod ljudi kodiran genom UTP20.[5][6][7][8]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 2.785 aminokiselina, a molekulska težina 318.385 Da.[9]
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MKTKPVSHKT | ENTYRFLTFA | ERLGNVNIDI | IHRIDRTASY | EEEVETYFFE | ||||
| GLLKWRELNL | TEHFGKFYKE | VIDKCQSFNQ | LVYHQNEIVQ | SLKTHLQVKN | ||||
| SFAYQPLLDL | VVQLARDLQM | DFYPHFPEFF | LTITSILETQ | DTELLEWAFT | ||||
| SLSYLYKYLW | RLMVKDMSSI | YSMYSTLLAH | KKLHIRNFAA | ESFTFLMRKV | ||||
| SDKNALFNLM | FLDLDKHPEK | VEGVGQLLFE | MCKGVRNMFH | SCTGQAVKLI | ||||
| LRKLGPVTET | ETQLPWMLIG | ETLKNMVKST | VSYISKEHFG | TFFECLQESL | ||||
| LDLHTKVTKT | NCCESSEQIK | RLLETYLILV | KHGSGTKIPT | PADVCKVLSQ | ||||
| TLQVASLSTS | CWETLLDVIS | ALILGENVSL | PETLIKETIE | KIFESRFEKR | ||||
| LIFSFSEVMF | AMKQFEQLFL | PSFLSYIVNC | FLIDDAVVKD | EALAILAKLI | ||||
| LNKAAPPTAG | SMAIEKYPLV | FSPQMVGFYI | KQKKTRSKGR | NEQFPVLDHL | ||||
| LSIIKLPPNK | DTTYLSQSWA | ALVVLPHIRP | LEKEKVIPLV | TGFIEALFMT | ||||
| VDKGSFGKGN | LFVLCQAVNT | LLSLEESSEL | LHLVPVERVK | NLVLTFPLEP | ||||
| SVLLLTDLYY | QRLALCGCKG | PLSQEALMEL | FPKLQANIST | GVSKIRLLTI | ||||
| RILNHFDVQL | PESMEDDGLS | ERQSVFAILR | QAELVPATVN | DYREKLLHLR | ||||
| KLRHDVVQTA | VPDGPLQEVP | LRYLLGMLYI | NFSALWDPVI | ELISSHAHEM | ||||
| ENKQFWKVYY | EHLEKAATHA | EKELQNDMTD | EKSVGDESWE | QTQEGDVGAL | ||||
| YHEQLALKTD | CQERLDHTNF | RFLLWRALTK | FPERVEPRSR | ELSPLFLRFI | ||||
| NNEYYPADLQ | VAPTQDLRRK | GKGMVAEEIE | EEPAAGDDEE | LEEEAVPQDE | ||||
| SSQKKKTRRA | AAKQLIAHLQ | VFSKFSNPRA | LYLESKLYEL | YLQLLLHQDQ | ||||
| MVQKITLDCI | MTYKHPHVLP | YRENLQRLLE | DRSFKEEIVH | FSISEDNAVV | ||||
| KTAHRADLFP | ILMRILYGRM | KNKTGSKTQG | KSASGTRMAI | VLRFLAGTQP | ||||
| EEIQIFLDLL | FEPVRHFKNG | ECHSAVIQAV | EDLDLSKVLP | LGRQHGILNS | ||||
| LEIVLKNISH | LISAYLPKIL | QILLCMTATV | SHILDQREKI | QLRFINPLKN | ||||
| LRRLGIKMVT | DIFLDWESYQ | FRTEEIDAVF | HGAVWPQISR | LGSESQYSPT | ||||
| PLLKLISIWS | RNARYFPLLA | KQKPGHPECD | ILTNVFAILS | AKNLSDATAS | ||||
| IVMDIVDDLL | NLPDFEPTET | VLNLLVTGCV | YPGIAENIGE | SITIGGRLIL | ||||
| PHVPAILQYL | SKTTISAEKV | KKKKNRAQVS | KELGILSKIS | KFMKDKEQSS | ||||
| VLITLLLPFL | HRGNIAEDTE | VDILVTVQNL | LKHCVDPTSF | LKPIAKLFSV | ||||
| IKNKLSRKLL | CTVFETLSDF | ESGLKYITDV | VKLNAFDQRH | LDDINFDVRF | ||||
| ETFQTITSYI | KEMQIVDVNY | LIPVMHNCFY | NLELGDMSLS | DNASMCLMSI | ||||
| IKKLAALNVT | EKDYREIIHR | SLLEKLRKGL | KSQTESIQQD | YTTILSCLIQ | ||||
| TFPNQLEFKD | LVQLTHYHDP | EMDFFENMKH | IQIHRRARAL | KKLAKQLMEG | ||||
| KVVLSSKSLQ | NYIMPYAMTP | IFDEKMLKHE | NITTAATEII | GAICKHLSWS | ||||
| AYMYYLKHFI | HVLQTGQINQ | KLGVSLLVIV | LEAFHFDHKT | LEEQMGKIEN | ||||
| EENAIEAIEL | PEPEAMELER | VDEEEKEYTC | KSLSDNGQPG | TPDPADSGGT | ||||
| SAKESECITK | PVSFLPQNKE | EIERTIKNIQ | GTITGDILPR | LHKCLASTTK | ||||
| REEEHKLVKS | KVVNDEEVVR | VPLAFAMVKL | MQSLPQEVME | ANLPSILLKV | ||||
| CALLKNRAQE | IRDIARSTLA | KIIEDLGVHF | LLYVLKELQT | TLVRGYQVHV | ||||
| LTFTVHMLLQ | GLTNKLQVGD | LDSCLDIMIE | IFNHELFGAV | AEEKEVKQIL | ||||
| SKVMEARRSK | SYDSYEILGK | FVGKDQVTKL | ILPLKEILQN | TTSLKLARKV | ||||
| HETLRRITVG | LIVNQEMTAE | SILLLSYGLI | SENLPLLTEK | EKNPVAPAPD | ||||
| PRLPPQSCLL | LPPTPVRGGQ | KAVVSRKTNM | HIFIESGLRL | LHLSLKTSKI | ||||
| KSSGECVLEM | LDPFVSLLID | CLGSMDVKVI | TGALQCLIWV | LRFPLPSIET | ||||
| KAEQLTKHLF | LLLKDYAKLG | AARGQNFHLV | VNCFKCVTIL | VKKVKSYQIT | ||||
| EKQLQVLLAY | AEEDIYDTSR | QATAFGLLKA | ILSRKLLVPE | IDEVMRKVSK | ||||
| LAVSAQSEPA | RVQCRQVFLK | YILDYPLGDK | LRPNLEFMLA | QLNYEHETGR | ||||
| ESTLEMIAYL | FDTFPQGLLH | ENCGMFFIPL | CLMTINDDSA | TCKKMASMTI | ||||
| KSLLGKISLE | KKDWLFDMVT | TWFGAKKRLN | RQLAALICGL | FVESEGVDFE | ||||
| KRLGTVLPVI | EKEIDPENFK | DIMEETEEKA | ADRLLFSFLT | LITKLIKECN | ||||
| IIQFTKPAET | LSKIWSHVHS | HLRHPHNWVW | LTAAQIFGLL | FASCQPEELI | ||||
| QKWNTKKTKK | HLPEPVAIKF | LASDLDQKMK | SISLASCHQL | HSKFLDQSLG | ||||
| EQVVKNLLFA | AKVLYLLELY | CEDKQSKIKE | DLEEQEALED | GVACADEKAE | ||||
| SDGEEKEEVK | EELGRPATLL | WLIQKLSRIA | KLEAAYSPRN | PLKRTCIFKF | ||||
| LGAVAMDLGI | DKVKPYLPMI | IAPLFRELNS | TYSEQDPLLK | NLSQEIIELL | ||||
| KKLVGLESFS | LAFASVQKQA | NEKRALRKKR | KALEFVTNPD | IAAKKKMKKH | ||||
| KNKSEAKKRK | IEFLRPGYKA | KRQKSHSLKD | LAMVE |
Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000120800 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004356 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Schwirzke M, Gnirke A, Bork P, Tarin D, Weidle UH (Aug 1998). "Differential gene expression in mammary carcinoma cell lines: identification of DRIM, a new gene down-regulated in metastasis". Anticancer Res. 18 (3A): 1409–21. PMID 9673349.
- ^ Bernstein KA, Gallagher JE, Mitchell BM, Granneman S, Baserga SJ (Dec 2004). "The small-subunit processome is a ribosome assembly intermediate". Eukaryot Cell. 3 (6): 1619–26. doi:10.1128/EC.3.6.1619-1626.2004. PMC 539036. PMID 15590835.
- ^ Peng WT, Robinson MD, Mnaimneh S, Krogan NJ, Cagney G, Morris Q, Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B, Wu LF, Altschuler SJ, Roweis S, Frey BJ, Emili A, Greenblatt JF, Hughes TR (Jul 2003). "A panoramic view of yeast noncoding RNA processing". Cell. 113 (7): 919–33. doi:10.1016/S0092-8674(03)00466-5. PMID 12837249. S2CID 10190539.
- ^ "Entrez Gene: UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)".
- ^ "UniProt, O75691". Pristupljeno 14. 8. 2021.
Dopunska literatura
[uredi | uredi izvor]- Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
- Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
- Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
- Goodison S, Viars C, Grazzini M, Urquidi V (2004). "The interrelationship between DRIM gene expression and cytogenetic and phenotypic characteristics in human breast tumor cell lines". BMC Genomics. 4 (1): 39. doi:10.1186/1471-2164-4-39. PMC 222913. PMID 14503924.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
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- Xing X, Du X, Lu Z, Ning T, Su X, Ke Y (2005). "Characterization of the promoter of 1A6/DRIM, a novel cancer-related gene and identification of its transcriptional activator". Gene. 344: 161–9. doi:10.1016/j.gene.2004.09.036. PMID 15656982.
- Yang L, Zhao J, Lü W, Li Y, Du X, Ning T, Lu G, Ke Y (2006). "KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential". Biochem. Biophys. Res. Commun. 334 (3): 884–90. doi:10.1016/j.bbrc.2005.06.179. PMID 16053918.
- Liu J, Du X, Ke Y (2006). "Mapping nucleolar localization sequences of 1A6/DRIM". FEBS Lett. 580 (5): 1405–10. doi:10.1016/j.febslet.2006.01.064. PMID 16458307. S2CID 29337295.
- Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
- Wang Y, Liu J, Zhao H, Lü W, Zhao J, Yang L, Li N, Du X, Ke Y (2007). "Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing". Biochim. Biophys. Acta. 1773 (6): 863–8. doi:10.1016/j.bbamcr.2007.04.002. PMID 17498821.