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5-Metilcitozin

Izvor: Wikipedija
5-Metilcitozin
IUPAC ime
Identifikacija
CAS registarski broj 554-01-8 DaY
PubChem[1][2] 65040
ChemSpider[3] 58551 DaY
UNII 6R795CQT4H DaY
KEGG[4] C02376
MeSH 5-Methylcytosine
ChEBI 27551
Jmol-3D slike Slika 1
Slika 2
Svojstva
Molekulska formula C5H7N3O
Molarna masa 125,129

 DaY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

5-Metilcitozin je metilisana forma DNK baze citozina. On može da učestvuje u regulaciji transkripcija gena. Kad je citozin metilisan, DNA zadržava istu sekvencu, dok ekspresija metilisanih gena može da bude promenjena.[5][6][7] Epigenetika se bavi studiranjem ovih promena.[8][9]

In vivo

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5-Metilcitozin je epigenetička modifikacija formirana dejstvom DNK metiltransferaze.

Reference

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  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Jiang-Cheng Shen, William M. Rideout III and Peter A. Jones (1994). „The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA”. Nucl. Acids Res. 22 (6): 972-976. DOI:10.1093/nar/22.6.972. 
  6. G. R. Wyatt (1951). „Recognition and estimation of 5-methylcytosine in nucleic acids”. Biochem J. 48 (5): 581–584. PMC 1275378. 
  7. Wang RY, Kuo KC, Gehrke CW, Huang LH, Ehrlich M (1982). „Heat- and alkali-induced deamination of 5-methylcytosine and cytosine residues in DNA”. Biochimica et Biophysica Acta 697 (3): 371-7. DOI:10.1016/0167-4781(82)90101-4. 
  8. Rudolf Jaenisch & Adrian Bird (2003). „Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals”. Nature Genetics 33: 245-254. DOI:10.1038/ng1089. 
  9. Angela A Andersen, Barbara Panning (2003). „Epigeneticgeneregulation by noncoding RNAs”. Current Opinion in Cell Biology 15 (3): 281–289. DOI:10.1016/S0955-0674(03)00041-3. 

Literatura

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  • Griffiths, Anthony J. F. (1999). An Introduction to genetic analysis. San Francisco: W.H. Freeman. Chapter 15: Gene Mutation. ISBN 0-7167-3520-2.  (available online at the United States National Center for Biotechnology Information)

Povezano

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Spoljašnje veze

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