7-Metilksantozin sintaza
| 7-Metilksantozin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.158 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
7-Metilksantozin sintaza (EC 2.1.1.158, ksantozinska metiltransferaza, XMT, ksantozin:S-adenozil-L-metionin metiltransferaza, CtCS1, CmXRS1, CaXMT1, S-adenozil-L-metionin:ksantozin 7-N-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:ksantozin N7-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + ksantozin S-adenozil-L-homocistein + 7-metilksantozin
Ovaj enzim je specifičan za ksantozin. XMP i ksantin nisu supstrati.
- ↑ Negishi, O., Ozawa, T. and Imagawa, H. (1985). „The role of xanthosine in the biosynthesis of caffeine in coffee plants”. Agric. Biol. Chem. 49: 2221-2222.
- ↑ Mizuno, K., Kato, M., Irino, F., Yoneyama, N., Fujimura, T. and Ashihara, H. (2003). „The first committed step reaction of caffeine biosynthesis: 7-methylxanthosine synthase is closely homologous to caffeine synthases in coffee (Coffea arabica L.)”. FEBS Lett. 547: 56-60. PMID 12860386.
- ↑ Uefuji, H., Ogita, S., Yamaguchi, Y., Koizumi, N. and Sano, H. (2003). „Molecular cloning and functional characterization of three distinct N-methyltransferases involved in the caffeine biosynthetic pathway in coffee plants”. Plant Physiol. 132: 372-380. PMID 12746542.
- ↑ Yoneyama, N., Morimoto, H., Ye, C.X., Ashihara, H., Mizuno, K. and Kato, M. (2006). „Substrate specificity of N-methyltransferase involved in purine alkaloids synthesis is dependent upon one amino acid residue of the enzyme”. Mol. Genet. Genomics 275: 125-135. PMID 16333668.
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