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Protein-coding gene in the species Homo sapiens
AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene .[ 5] [ 6] [ 7]
This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system.[ 7]
AP4M1 has been shown to interact with AP4B1 .[ 8]
The AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.[ 9] spastic paraplegia 50 , one of the many subtypes of spastic paraplegia .
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