Arogenat dehidrogenaza (NADP+)
| Arogenat dehidrogenaza (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.78 | ||||||||
| CAS broj | 64295-75-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Arogenat dehidrogenaza (NADP+) (EC 1.3.1.78, arogenatna dehidrogenaza (nespecifična), pretirozinska dehidrogenaza (nespecifična), TyrAAT1, TyrAAT2, TyrAa) je enzim sa sistematskim imenom L-arogenat:NADP+ oksidoreduktaza (dekarboksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-arogenat + NADP+ L-tirozin + NADPH + CO2
Za razliku od EC 1.3.1.43 (arogenat dehidrogenaze) i EC 1.3.1.79 [arogenat dehidrogenaze (NAD(P)+)], ovaj enzim enzim koristi samo NADP+. Enzim iz Synechocystis sp. PCC 6803 i izoforme TyrAAT1 ne može da koristi prefenat kao supstrat, dok izoforma TyrAAT2 može da ga koristi, mada veome slabo.
- ↑ Byng, G., Whitaker, R., Flick, C. and Jensen, R.A. (1981). „Enzymology of L-tyrosine biosynthesis in corn (Zea mays)”. Phytochemistry 20: 1289-1292.
- ↑ Gaines, C.G., Byng, G.S., Whitaker, R.J. and Jensen, R.A. (1982). „L-Tyrosine regulation and biosynthesis via arogenate dehydrogenase in suspension-cultured cells of Nicotiana silvestris Speg. et Comes”. Planta 156: 233-240.
- ↑ Rippert, P. and Matringe, M. (2002). „Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana”. Eur. J. Biochem. 269: 4753-4761. PMID 12354106.
- ↑ Bonner, C.A., Jensen, R.A., Gander, J.E. and Keyhani, N.O. (2004). „A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis”. Biochem. J. 382: 279-291. PMID 15171683.
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- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
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