CD247

CD247
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1TCE, 1YGR, 2HAC, 2OQ1, 3IK5, 3IOZ, 4XZ1
Dynodwyr
Cyfenwau	CD247, CD3-ZETA, CD3H, CD3Q, CD3Z, IMD25, T3Z, TCRZ, CD247 molecule, CD3zeta
Dynodwyr allanol	OMIM: 186780 HomoloGene: 12818 GeneCards: CD247
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • transmembrane signaling receptor activity • identical protein binding • protein homodimerization activity • protein tyrosine kinase binding Cydrannau o'r gell • cytoplasm • integral component of membrane • alpha-beta T cell receptor complex • Cellbilen • T cell receptor complex • bilen Prosesau biolegol • cell surface receptor signaling pathway • GO:0019049, GO:0030683 mitigation of host defenses by virus • T cell receptor signaling pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • regulation of immune response • GO:0022415 viral process • protein homotetramerization • protein homotrimerization • adaptive immune response • immune system process • interleukin-2 production • positive regulation of protein localization to cell surface Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	919	n/a
Ensembl	ENSG00000198821	n/a
UniProt	P20963	n/a
RefSeq (mRNA)	NM_000734 NM_198053 NM_001378515 NM_001378516	n/a
RefSeq (protein)	NP_000725 NP_932170 NP_001365444 NP_001365445	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CD247 yw CD247 a elwir hefyd yn CD247 molecule (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q24.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CD247.

• T3Z
• CD3H
• CD3Q
• CD3Z
• TCRZ
• IMD25
• CD3-ZETA

Llyfryddiaeth

• "Analysis of the recovery of CD247 expression in a PID patient: insights into the spontaneous repair of defective genes. ". Blood. 2017. PMID 28743717.
• "Association of CD247 (CD3ζ) gene polymorphisms with T1D and AITD in the population of northern Sweden. ". BMC Med Genet. 2016. PMID 27716086.
• "TCR-CD3ζ gene polymorphisms and expression profile in rheumatoid arthritis. ". Autoimmunity. 2016. PMID 27118209.
• "A novel thymoma-associated immunodeficiency with increased naive T cells and reduced CD247 expression. ". J Immunol. 2015. PMID 25732729.
• "Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study.". Genes Immun. 2015. PMID 25569266.