CD2

CD2 molecule
	Estrutura proteica de CD2 a partir de PDB 1hnf
Estruturas disponíveis
PDB	Busca de ortólogos: PDBe, RCSB
Lista de códigos PDB
	1CDB, 1GYA, 1HNF, 1L2Z, 1QA9, 2J6O, 2J7I
Identificadores
Símbolos	CD2; LFA-2; SRBC; T11
IDs externos	OMIM: 186990 MGI: 88320 HomoloGene: 1338 ChEMBL: 2040 GeneCards: CD2 Gene
Ontologia do gene
Função molecular	•receptor activity; •receptor binding; •protein binding; •protein homodimerization activity;
Componente celular	•extracellular region; •plasma membrane; •integral component of plasma membrane; •external side of plasma membrane; •cytoplasmic side of plasma membrane; •cell surface; •anchored component of plasma membrane;
Processo biológico	•membrane raft polarization; •apoptotic process; •cell surface receptor signaling pathway; •blood coagulation; •single organismal cell-cell adhesion; •natural killer cell activation; •positive regulation of myeloid dendritic cell activation; •positive regulation of tumor necrosis factor production; •heterotypic cell-cell adhesion; •T cell activation; •regulation of T cell differentiation; •leukocyte migration; •positive regulation of interferon-gamma secretion; •positive regulation of interleukin-8 secretion;
	Sources: Amigo / QuickGO
Padrões de expressão do ARN
	Mais dados de expressão
Ortólogos
	v; d; e;

O CD2 (cluster of differentiation 2) é uma molécula de adesão celular encontrada na superfície de linfócito T e células NK (Natural Killer).^[1] É também chamada de antígeno de superfície de células T T11/Leu-5, LFA-2, receptor LFA-3, receptor de eritrócitos e receptor em roseta.

Função

Interage com outras moléculas de adesão, como o antígeno-3 linfócito-funcional (LFA-3/CD58) em humanos, ou o CD48 em roedores, o qual é expressado na superfície de outras células.

Além de suas propriedades de adesão, atua como molécula co-estimulatória no linfócito T e NK.

Referências

↑ Wilkins A, Yang W, Yang J (2003). «Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design». Curr Protein Pept Sci. 4 (5): 367–73. PMID 14529530. doi:10.2174/1389203033487063

Leitura de apoio

Sayre PH, Reinherz EL (1989). «Structure and function of the erythrocyte receptor CD2 on human T lymphocytes: a review.». Scand. J. Rheumatol. Suppl. 76: 131–44. PMID 2471997
Rouleau M, Mollereau B, Bernard A; et al. (1997). «CD2 induced apoptosis of peripheral T cells.». Transplant. Proc. 29 (5): 2377–8. PMID 9270771. doi:10.1016/S0041-1345(97)00410-7
Lüscher B (2001). «Function and regulation of the transcription factors of the Myc/Max/Mad network.». Gene. 277 (1-2): 1–14. PMID 11602341. doi:10.1016/S0378-1119(01)00697-7
Yang JJ, Ye Y, Carroll A; et al. (2002). «Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation.». Curr. Protein Pept. Sci. 2 (1): 1–17. PMID 12369898. doi:10.2174/1389203013381251
Bell GM, Seaman WE, Niemi EC, Imboden JB (1992). «The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line.». J. Exp. Med. 175 (2): 527–36. PMC 2119111. PMID 1346273. doi:10.1084/jem.175.2.527
Marie-Cardine A, Maridonneau-Parini I, Ferrer M; et al. (1992). «The lymphocyte-specific tyrosine protein kinase p56lck is endocytosed in Jurkat cells stimulated via CD2.». J. Immunol. 148 (12): 3879–84. PMID 1351089
Hahn WC, Menu E, Bothwell AL; et al. (1992). «Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59.». Science. 256 (5065): 1805–7. PMID 1377404. doi:10.1126/science.1377404
Luzzati AL, Giacomini E, Giordani L; et al. (1992). «The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope.». Immunol. Lett. 33 (3): 307–14. PMID 1385321. doi:10.1016/0165-2478(92)90078-3
Ruegg CL, Strand M (1991). «A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx.». Cell. Immunol. 137 (1): 1–13. PMID 1832084. doi:10.1016/0008-8749(91)90051-C
Schraven B, Samstag Y, Altevogt P, Meuer SC (1990). «Association of CD2 and CD45 on human T lymphocytes.». Nature. 345 (6270): 71–4. PMID 1970422. doi:10.1038/345071a0
Samelson LE, Fletcher MC, Ledbetter JA, June CH (1990). «Activation of tyrosine phosphorylation in human T cells via the CD2 pathway. Regulation by the CD45 tyrosine phosphatase.». J. Immunol. 145 (8): 2448–54. PMID 1976695
Luzzati AL, Pugliese O, Giacomini E; et al. (1990). «Immunoregulatory effect of a synthetic peptide corresponding to a region of protein p24 of HIV.». Folia Biol. (Praha). 36 (1): 71–7. PMID 2111780
Seed B, Aruffo A (1987). «Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.». Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3365–9. PMC 304871. PMID 2437578. doi:10.1073/pnas.84.10.3365
Peterson A, Seed B (1987). «Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2).». Nature. 329 (6142): 842–6. PMID 2444890. doi:10.1038/329842a0
Sayre PH, Chang HC, Hussey RE; et al. (1987). «Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes.». Proc. Natl. Acad. Sci. U.S.A. 84 (9): 2941–5. PMC 304776. PMID 2883656. doi:10.1073/pnas.84.9.2941
Diamond DJ, Clayton LK, Sayre PH, Reinherz EL (1988). «Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes.». Proc. Natl. Acad. Sci. U.S.A. 85 (5): 1615–9. PMC 279824. PMID 2894031. doi:10.1073/pnas.85.5.1615
Lang G, Wotton D, Owen MJ; et al. (1988). «The structure of the human CD2 gene and its expression in transgenic mice.». EMBO J. 7 (6): 1675–82. PMC 457152. PMID 2901953
Leca G, Boumsell L, Fabbi M; et al. (1986). «The sheep erythrocyte receptor and both alpha and beta chains of the human T-lymphocyte antigen receptor bind the mitogenic lectin (phytohaemagglutinin) from Phaseolus vulgaris.». Scand. J. Immunol. 23 (5): 535–44. PMID 3085210. doi:10.1111/j.1365-3083.1986.tb01985.x
Sewell WA, Brown MH, Dunne J; et al. (1986). «Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen.». Proc. Natl. Acad. Sci. U.S.A. 83 (22): 8718–22. PMC 387002. PMID 3490670. doi:10.1073/pnas.83.22.8718

[1] Wilkins A, Yang W, Yang J (2003). «Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design». Curr Protein Pept Sci. 4 (5): 367–73. PMID 14529530. doi:10.2174/1389203033487063

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