DNAJC28

DNAJC28
Identifikatori
Aliasi	DNAJC28
Vanjski ID-jevi	MGI: 2181053 HomoloGene: 9869 GeneCards: DNAJC28
Lokacija gena (čovjek)
Hrom.	Hromosom 21 (čovjek)
Kraj	33,491,716 bp
Lokacija gena (miš)
Hrom.	Hromosom 16 (miš)
Kraj	91,415,914 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• Golgi transport complex;
Biološki proces	• retrograde transport, vesicle recycling within Golgi; • Golgi vesicle prefusion complex stabilization; • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; • Golgi organization;
	Izvori:Amigo / QuickGO
Ortolozi
	54943
	246738
	ENSG00000262911; ENSG00000177692
	ENSMUSG00000039763
	Q9NX36
	Q8VCE1
	NM_001040192; NM_017833; NM_001320746
	NM_001099738; NM_138664
	NP_001035282; NP_001307675; NP_060303
	NP_001093208; NP_619605
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Član 28 homologa DnaJ potporodice C jest protein koji je kod ljudi kodiran genom DNAJC28 sa hromosoma 21.^[5] Član je porodice šaperona Dnaj . Članovi poosice poznati su i kao Hsp40 (proteini toplotnog šoka od 40 kDa).

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 388 aminokiselina, a molekulska težina 45.806 Da.^[5]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MNTMYVMMAQ	ILRSHLIKAT	VIPNRVKMLP	YFGIIRNRMM	STHKSKKKIR
EYYRLLNVEE	GCSADEVRES	FHKLAKQYHP	DSGSNTADSA	TFIRIEKAYR
KVLSHVIEQT	NASQSKGEEE	EDVEKFKYKT	PQHRHYLSFE	GIGFGTPTQR
EKHYRQFRAD	RAAEQVMEYQ	KQKLQSQYFP	DSVIVKNIRQ	SKQQKITQAI
ERLVEDLIQE	SMAKGDFDNL	SGKGKPLKKF	SDCSYIDPMT	HNLNRILIDN
GYQPEWILKQ	KEISDTIEQL	REAILVSRKK	LGNPMTPTEK	KQWNHVCEQF
QENIRKLNKR	INDFNLIVPI	LTRQKVHFDA	QKEIVRAQKI	YETLIKTKEV
TDRNPNNLDQ	GEGEKTPEIK	KGFLNWMNLW	KFIKIRSF

Reference

^ ^a ^b ^c ENSG00000177692 GRCh38: Ensembl release 89: ENSG00000262911, ENSG00000177692 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039763 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 [ Homo sapiens (human) ]".

Dopunska literatura

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gardiner K, Slavov D, Bechtel L, Davisson M (2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis". Genomics. 79 (6): 833–43. doi:10.1006/geno.2002.6782. PMID 12036298.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

Vanjski linkovi

Lokacija ljudskog genoma DNAJC28 i stranica sa detaljima o genu DNAJC28 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] ENSG00000177692 GRCh38: Ensembl release 89: ENSG00000262911, ENSG00000177692 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039763 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 [ Homo sapiens (human) ]".

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