DUSP10

DUSP10
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1ZZW, 2OUC, 2OUD, 3TG1
Identifikatori
Aliasi	DUSP10
Vanjski ID-jevi	OMIM: 608867 MGI: 1927070 HomoloGene: 5215 GeneCards: DUSP10
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	183,807,833 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0098519, GO:0098518 phosphatase activity; • protein tyrosine phosphatase activity; • MAP kinase tyrosine/serine/threonine phosphatase activity; • hydrolase activity; • protein tyrosine/serine/threonine phosphatase activity; • JUN kinase binding; • MAP kinase phosphatase activity; • mitogen-activated protein kinase p38 binding; • phosphoprotein phosphatase activity; • protein tyrosine/threonine phosphatase activity; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• Golđijev aparat; • nukleoplazma; • citosol; • nuclear speck; • jedro; • citoplazma;
Biološki proces	• regulation of innate immune response; • regulation of adaptive immune response; • oligodendrocyte differentiation; • negative regulation of respiratory burst involved in inflammatory response; • response to organic substance; • response to lipopolysaccharide; • negative regulation of oligodendrocyte differentiation; • negative regulation of protein kinase activity by regulation of protein phosphorylation; • negative regulation of stress-activated MAPK cascade; • regulation of brown fat cell differentiation; • GO:0098501, GO:0098502, GO:0006286 Defosforilacija; • positive regulation of regulatory T cell differentiation; • GO:0016576 protein dephosphorylation; • negative regulation of epithelial cell migration; • negative regulation of cell migration; • peptidyl-threonine dephosphorylation; • negative regulation of JUN kinase activity; • negative regulation of JNK cascade; • negative regulation of epithelial cell proliferation; • negative regulation of ERK1 and ERK2 cascade; • negative regulation of p38MAPK cascade; • negative regulation of epithelium regeneration; • peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;
	Izvori:Amigo / QuickGO
Ortolozi
	11221
	63953
	n/a
	ENSMUSG00000039384
	Q9Y6W6
	Q9ESS0
	NM_007207; NM_144728; NM_144729
	NM_022019
	NP_009138
	NP_071302
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Dvospecifična protein-fosfataza 10 jest enzim koji je kod ljudi kodiran genom DUSP10 sa hromosoma 1.^[4]^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 482 aminokiseline, a molekulska težina 52.642 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPPSPLDDRV	VVALSRPVRP	QDLNLCLDSS	YLGSANPGSN	SHPPVIATTV
VSLKAANLTY	MPSSSGSARS	LNCGCSSASC	CTVATYDKDN	QAQTQAIAAG
TTTTAIGTST	TCPANQMVNN	NENTGSLSPS	SGVGSPVSGT	PKQLASIKII
YPNDLAKKMT	KCSKSHLPSQ	GPVIIDCRPF	MEYNKSHIQG	AVHINCADKI
SRRRLQQGKI	TVLDLISCRE	GKDSFKRIFS	KEIIVYDENT	NEPSRVMPSQ
PLHIVLESLK	REGKEPLVLK	GGLSSFKQNH	ENLCDNSLQL	QECREVGGGA
SAASSLLPQP	IPTTPDIENA	ELTPILPFLF	LGNEQDAQDL	DTMQRLNIGY
VINVTTHLPL	YHYEKGLFNY	KRLPATDSNK	QNLRQYFEEA	FEFIEEAHQC
GKGLLIHCQA	GVSRSATIVI	AYLMKHTRMT	MTDAYKFVKG	KRPIISPNLN
FMGQLLEFEE	DLNNGVTPRI	LTPKLMGVET	VV

Funkcija

Dvospecifične proteinske fosfataze inaktiviraju svoje ciljne kinaze defosforilacijom i fosfoserin/treonin[]skih i fosfotirozinskih ostataka. Oni negativno regulišu članove natporeodice MAPK (MAPK/ERK, SAPK/JNK, p38), što je povezano sa ćelijskom proliferacijom i diferencijacijom. Različiti članovi ove porodice fosfataza dvostruke specifičnosti pokazuju različite specifičnosti supstrata za MAPK, različitu distribuciju tkiva i subćelijsku lokalizaciju, te različite načine inducibilnosti njihove ekspresije vanćelijskim stimulansima. Ovaj genski proizvod veže se i inaktivira p38 i SAPK/JNK, ali ne i MAPK/ERK. Njegova subćelijska lokalizacija je jedinstvena; ravnomjerno je raspoređen i u citoplazmi i u jedru. Ovaj gen je široko eksprimiran u različitim tkivima i organima, a njegova ekspresija je pojačana stresnim podražajima. Za ovaj gen su pronađene tri varijante transkripta koje kodiraju dvije različite izoforme.^[6]

Interakcije

Pokazalo se da DUSP10 ima interakcije sa MAPK14^[8]^[9]^[10] i MAPK8.^[4]

Reference

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039384 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Tanoue T, Moriguchi T, Nishida E (Aug 1999). "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5". J Biol Chem. 274 (28): 19949–56. doi:10.1074/jbc.274.28.19949. PMID 10391943.
^ Theodosiou A, Smith A, Gillieron C, Arkinstall S, Ashworth A (Jan 2000). "MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases". Oncogene. 18 (50): 6981–8. doi:10.1038/sj.onc.1203185. PMID 10597297.
^ ^a ^b "Entrez Gene: DUSP10 dual specificity phosphatase 10".
^ "UniProt, Q9Y6W6" (jezik: en.). Pristupljeno 9. 12. 2021.CS1 održavanje: nepoznati jezik (link)
^ Tanoue, T; Moriguchi T; Nishida E (Jul 1999). "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5". J. Biol. Chem. UNITED STATES. 274 (28): 19949–56. doi:10.1074/jbc.274.28.19949. ISSN 0021-9258. PMID 10391943.
^ Tanoue, T; Yamamoto T; Maeda R; Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J. Biol. Chem. United States. 276 (28): 26629–39. doi:10.1074/jbc.M101981200. ISSN 0021-9258. PMID 11359773.
^ Tanoue, T; Maeda R; Adachi M; Nishida E (Feb 2001). "Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions". EMBO J. England. 20 (3): 466–79. doi:10.1093/emboj/20.3.466. ISSN 0261-4189. PMC 133461. PMID 11157753.

Dopunska litratura

Martell KJ, Angelotti T, Ullrich A (1998). "The "VH1-like" dual-specificity protein tyrosine phosphatases". Mol. Cells. 8 (1): 2–11. PMID 9571625.
Teng CH, Huang WN, Meng TC (2007). "Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress". J. Biol. Chem. 282 (39): 28395–407. doi:10.1074/jbc.M705142200. PMID 17681939.
Tao X, Tong L (2007). "Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5". Protein Sci. 16 (5): 880–6. doi:10.1110/ps.062712807. PMC 2206639. PMID 17400920.
Nonn L, Duong D, Peehl DM (2007). "Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells". Carcinogenesis. 28 (6): 1188–96. doi:10.1093/carcin/bgl241. PMID 17151092.
Jeong DG, Yoon TS, Kim JH, et al. (2006). "Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase". J. Mol. Biol. 360 (5): 946–55. doi:10.1016/j.jmb.2006.05.059. PMID 16806267.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tanoue T, Yamamoto T, Maeda R, Nishida E (2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J. Biol. Chem. 276 (28): 26629–39. doi:10.1074/jbc.M101981200. PMID 11359773.
Masuda K, Shima H, Kikuchi K, et al. (2000). "Expression and comparative chromosomal mapping of MKP-5 genes DUSP10/Dusp10". Cytogenet. Cell Genet. 90 (1–2): 71–4. doi:10.1159/000015666. PMID 11060451. S2CID 30344543.

Šablon:Protein tirozin-fosfataze

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000039384 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10391943-4] Tanoue T, Moriguchi T, Nishida E (Aug 1999). "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5". J Biol Chem. 274 (28): 19949–56. doi:10.1074/jbc.274.28.19949. PMID 10391943.

[pmid10597297-5] Theodosiou A, Smith A, Gillieron C, Arkinstall S, Ashworth A (Jan 2000). "MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases". Oncogene. 18 (50): 6981–8. doi:10.1038/sj.onc.1203185. PMID 10597297.

[entrez-6] "Entrez Gene: DUSP10 dual specificity phosphatase 10".

[UniProt-7] "UniProt, Q9Y6W6" (jezik: en.). Pristupljeno 9. 12. 2021.CS1 održavanje: nepoznati jezik (link)

[autogenerated1-8] Tanoue, T; Moriguchi T; Nishida E (Jul 1999). "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5". J. Biol. Chem. UNITED STATES. 274 (28): 19949–56. doi:10.1074/jbc.274.28.19949. ISSN 0021-9258. PMID 10391943.

[pmid11359773-9] Tanoue, T; Yamamoto T; Maeda R; Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J. Biol. Chem. United States. 276 (28): 26629–39. doi:10.1074/jbc.M101981200. ISSN 0021-9258. PMID 11359773.

[pmid11157753-10] Tanoue, T; Maeda R; Adachi M; Nishida E (Feb 2001). "Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions". EMBO J. England. 20 (3): 466–79. doi:10.1093/emboj/20.3.466. ISSN 0261-4189. PMC 133461. PMID 11157753.

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak